SMAD9 and ARHGAP9

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		SMAD9	ARHGAP9
Description		SMAD family member 9	Rho GTPase activating protein 9
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol SMAD Protein Complex Heteromeric SMAD Protein Complex	Extracellular Region Cytoplasm Cytosol Plasma Membrane Secretory Granule Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding I-SMAD Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding
	Biological Process	Osteoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Morphogenesis Cell Differentiation BMP Signaling Pathway Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation SMAD Protein Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway	Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Signaling by BMP	Neutrophil degranulation RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Heel bone mineral density ( 28869591 30598549) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Spontaneous preterm birth (preterm birth) ( 25599974) Total body bone mineral density ( 29304378)	Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494)
Interacting Genes		117 interacting genes: ABTB1 ACTB ACVR1 AFF1 AP2A1 ARHGAP9 ARID1B ARNT ASB2 ASH2L BAZ1A BTG2 CAMSAP1 CEP135 CHPF CLPB CPXM2 CSH1 CSH2 CTR9 CXXC5 CYP11A1 DIAPH3 DKK1 DNAJA3 DNAJC7 DST DSTN E4F1 EIF3C EIF3E EIF3F ERVV-1 EVC2 EXPH5 FLI1 FN1 FTL GRN HEY1 HEYL HUWE1 KDM1A KDM6A KMT2D LEMD3 LMO4 LNPEP LRP5 MACO1 MAN1A2 MAN1C1 MAN2B1 MBD1 MCM3AP METAP1 MGAT1 MTMR10 MTMR11 NAGK OTUB1 PABPC4 PAPPA PELP1 PHKA2 PIR PKP2 PLEC PNPLA2 PPARD PPP2R5E PRMT6 PSAP PSMD8 QARS1 RANBP9 RFX1 RMND5A RNF123 RRBP1 RUBCN SECISBP2 SF3B1 SIL1 SKIC3 SMAD2 SMAD3 SMAD4 SMG1 SNRNP70 SPTBN1 STAG1 SVEP1 TBCD TERF1 TINAGL1 TOB1 TRIM29 TRIP12 TWNK UBA6 UBE3A UBQLN1 UBQLN4 UNC45A VCPIP1 VPS8 XAB2 YWHAQ ZEB2 ZNF484 ZNF557 ZNF587 ZNF587B ZNF592 ZNF83 ZSCAN4	17 interacting genes: ABI3 AKT1 APP CYSRT1 FASLG FHL2 GOLGA6A GOLGA6L9 HOMEZ MRPL38 NME7 RAC1 RBPMS RUNX1T1 SMAD9 SNRPC TSC22D4
Entrez ID		4093	64333
HPRD ID		04484	06449
Ensembl ID		ENSG00000120693	ENSG00000123329
Uniprot IDs		O15198	B3KQ74 Q9BRR9
PDB IDs		6FZT	2P0D 2P0F 2P0H
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Ameboidal-type Cell Migration Nucleus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Catabolic Process Regulation Of SMAD Protein Signal Transduction Regulation Of Gene Expression Macromolecule Biosynthetic Process SMAD Protein Complex Protein Metabolic Process Regulation Of RNA Metabolic Process Gastrulation Anterior/posterior Pattern Specification Heteromeric SMAD Protein Complex Nucleoplasm Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process R-SMAD Binding Histone Methyltransferase Complex Proteolysis Activin Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Metal Ion Binding Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process MLL3/4 Complex Endoderm Development Catabolic Process Protein Catabolic Process Regionalization Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Negative Regulation Of Autophagosome Maturation Golgi Apparatus Mannose Trimming Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Regulation Of Organelle Organization Ventricular Septum Morphogenesis	Regulation Of Postsynapse Organization Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Postsynapse Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Mediated Signaling Pathway Regulation Of Synapse Organization Osteoblast Differentiation Response To Growth Factor SMAD Protein Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Lymphocyte Apoptotic Process T Cell Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Lamellipodium Regulation Of Fibroblast Migration Response To Nerve Growth Factor Regulation Of Protein Localization To Membrane Regulation Of TRNA Methylation Positive Regulation Of Nitric Oxide Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Dendritic Shaft Regulation Of Synapse Assembly Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Dendrite Development Regulation Of Ruffle Assembly Regulation Of Lamellipodium Assembly Leukocyte Apoptotic Process Homeostatic Process Chemical Homeostasis Intracellular Signaling Cassette Negative Regulation Of Protein Localization Regulation Of Lamellipodium Organization Regulation Of Neuron Apoptotic Process Regulation Of Leukocyte Migration Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Projection Assembly Negative Regulation Of RNA Metabolic Process Response To Peptide Response To Cytokine Negative Regulation Of Protein Localization To Lysosome Acetylcholine Receptor Activator Activity Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
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