SMAD9 and CYP11A1

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SMAD9	CYP11A1
Gene Name		SMAD family member 9	cytochrome P450, family 11, subfamily A, polypeptide 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol	Mitochondrion Mitochondrial Matrix Mitochondrial Crista Perikaryon
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Metal Ion Binding	Iron Ion Binding Cholesterol Monooxygenase (side-chain-cleaving) Activity Cholesterol Binding Heme Binding
	Biological Process	Ureteric Bud Development Response To Hypoxia Mullerian Duct Regression Transcription, DNA-templated Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Midbrain Development Hindbrain Development Intracellular Signal Transduction Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Cartilage Development Bone Development Cellular Response To Organic Cyclic Compound	C21-steroid Hormone Biosynthetic Process Progesterone Biosynthetic Process Estrogen Biosynthetic Process Xenobiotic Metabolic Process Mating Behavior Steroid Metabolic Process Cholesterol Metabolic Process Response To Salt Stress Response To Gamma Radiation Schwann Cell Differentiation Sterol Metabolic Process Response To Insecticide Biphenyl Metabolic Process Dibenzo-p-dioxin Metabolic Process Phenol-containing Compound Metabolic Process Phthalate Metabolic Process Cerebellum Development Hippocampus Development Response To Vitamin E Leydig Cell Differentiation Response To L-ascorbic Acid Response To Genistein Vitamin D Metabolic Process Response To Drug Response To Hydrogen Peroxide Response To Alkaloid Small Molecule Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Fractalkine Metabolic Process Response To Corticosterone Oxidation-reduction Process Granulosa Cell Differentiation Maternal Process Involved In Female Pregnancy Response To Fungicide Testosterone Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Antibiotic Cellular Response To Cadmium Ion Cellular Response To CAMP Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Signaling by BMP	Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Pregnenolone biosynthesis Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS
Protein-Protein Interactions		117 interactors: ABTB1 ACTB ACVR1 AFF1 AP2A1 ARHGAP9 ARID1B ARNT ASB2 ASH2L BAZ1A BTG2 C10orf2 CAMSAP1 CEP135 CHPF CLPB CPXM2 CSH1 CSH2 CTR9 CXXC5 CYP11A1 DIAPH3 DKK1 DNAJA3 DNAJC7 DST DSTN E4F1 EIF3C EIF3E EIF3F ERVV-1 EVC2 EXPH5 FLI1 FN1 FTL GRN HEY1 HEYL HUWE1 KDM1A KDM6A KIAA0226 KMT2D LEMD3 LMO4 LNPEP LRP5 MAN1A2 MAN1C1 MAN2B1 MBD1 MCM3AP METAP1 MGAT1 MTMR10 MTMR11 NAGK OTUB1 PABPC4 PAPPA PELP1 PHKA2 PIR PKP2 PLEC PNPLA2 PPARD PPP2R5E PRMT6 PSAP PSMD8 QARS RANBP9 RFX1 RMND5A RNF123 RRBP1 SECISBP2 SF3B1 SIL1 SMAD2 SMAD3 SMAD4 SMG1 SNRNP70 SPTBN1 STAG1 SVEP1 TBCD TERF1 TINAGL1 TMEM57 TOB1 TRIM29 TRIP12 TTC37 UBA6 UBE3A UBQLN1 UBQLN4 UNC45A VCPIP1 VPS8 XAB2 YWHAQ ZEB2 ZNF484 ZNF557 ZNF587 ZNF587B ZNF592 ZNF83 ZSCAN4	5 interactors: CYP11B2 FDX1 SMAD2 SMAD3 SMAD9
Entrez ID		4093	1583
HPRD ID		04484	00326
Ensembl ID		ENSG00000120693	ENSG00000140459
Uniprot IDs		O15198	P05108
PDB IDs			3N9Y 3N9Z 3NA0 3NA1
Enriched GO Terms of Interacting Partners?		Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Gene Expression Cellular Metabolic Process Transcription, DNA-templated Biosynthetic Process RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Gastrulation Anterior/posterior Pattern Specification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Developmental Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Atrioventricular Valve Morphogenesis Endoderm Development Nitrogen Compound Metabolic Process Formation Of Primary Germ Layer Cell Differentiation Atrioventricular Valve Development Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Transcription From RNA Polymerase II Promoter Organ Development Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Embryo Development Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process SMAD Protein Complex Assembly Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Pattern Specification Process	Primary MiRNA Processing SMAD Protein Complex Assembly Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Paraxial Mesoderm Morphogenesis Mesonephros Development Transforming Growth Factor Beta Receptor Signaling Pathway Kidney Epithelium Development Cellular Response To Transforming Growth Factor Beta Stimulus Nodal Signaling Pathway Response To Transforming Growth Factor Beta Embryonic Foregut Morphogenesis Foregut Morphogenesis Paraxial Mesoderm Development Production Of MiRNAs Involved In Gene Silencing By MiRNA C21-steroid Hormone Biosynthetic Process Pericardium Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Hormone Levels C21-steroid Hormone Metabolic Process Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Kidney Development Gene Silencing By MiRNA Cellular Response To DsRNA Renal System Development Posttranscriptional Gene Silencing Urogenital System Development SMAD Protein Signal Transduction Positive Regulation Of Stem Cell Differentiation Cellular Response To Organic Cyclic Compound Hormone Biosynthetic Process Regulation Of Epithelial To Mesenchymal Transition Embryonic Cranial Skeleton Morphogenesis Digestive Tract Morphogenesis Gene Silencing By RNA Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To DsRNA Endoderm Development Embryonic Pattern Specification Mesoderm Formation Skeletal System Development Mesoderm Morphogenesis Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Gene Silencing
Tagcloud ?			aas aass abused anabolic androgenic arr19 dax1 disturbed enanthate gnrhr hsd17b4 hsd3b1 hsd3b5 insl3 intramuscular leydig lhcgr milieu oppositely prka prlr1 prlr2 prolactin star steroidogenesis steroidogenic testosterone tspo
Tagcloud (Difference) ?			aas aass abused anabolic androgenic arr19 dax1 disturbed enanthate gnrhr hsd17b4 hsd3b1 hsd3b5 insl3 intramuscular leydig lhcgr milieu oppositely prka prlr1 prlr2 prolactin star steroidogenesis steroidogenic testosterone tspo
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