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SMAD9 and UBE3A
Number of citations of the paper that reports this interaction (PMID
15231748
)
65
Data Source:
HPRD
(two hybrid)
SMAD9
UBE3A
Gene Name
SMAD family member 9
ubiquitin protein ligase E3A
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
Proteasome Complex
Nucleus
Cytoplasm
Cytosol
Molecular Function
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity
Metal Ion Binding
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Ligase Activity
Biological Process
Ureteric Bud Development
Response To Hypoxia
Mullerian Duct Regression
Transcription, DNA-templated
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Intracellular Signal Transduction
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Cartilage Development
Bone Development
Cellular Response To Organic Cyclic Compound
Ovarian Follicle Development
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Brain Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Androgen Receptor Signaling Pathway
Sperm Entry
Regulation Of Circadian Rhythm
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Protein Autoubiquitination
Prostate Gland Growth
Protein K48-linked Ubiquitination
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways
Signaling by BMP
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Cardiac hypertrophy (
21348951
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
117 interactors:
ABTB1
ACTB
ACVR1
AFF1
AP2A1
ARHGAP9
ARID1B
ARNT
ASB2
ASH2L
BAZ1A
BTG2
C10orf2
CAMSAP1
CEP135
CHPF
CLPB
CPXM2
CSH1
CSH2
CTR9
CXXC5
CYP11A1
DIAPH3
DKK1
DNAJA3
DNAJC7
DST
DSTN
E4F1
EIF3C
EIF3E
EIF3F
ERVV-1
EVC2
EXPH5
FLI1
FN1
FTL
GRN
HEY1
HEYL
HUWE1
KDM1A
KDM6A
KIAA0226
KMT2D
LEMD3
LMO4
LNPEP
LRP5
MAN1A2
MAN1C1
MAN2B1
MBD1
MCM3AP
METAP1
MGAT1
MTMR10
MTMR11
NAGK
OTUB1
PABPC4
PAPPA
PELP1
PHKA2
PIR
PKP2
PLEC
PNPLA2
PPARD
PPP2R5E
PRMT6
PSAP
PSMD8
QARS
RANBP9
RFX1
RMND5A
RNF123
RRBP1
SECISBP2
SF3B1
SIL1
SMAD2
SMAD3
SMAD4
SMG1
SNRNP70
SPTBN1
STAG1
SVEP1
TBCD
TERF1
TINAGL1
TMEM57
TOB1
TRIM29
TRIP12
TTC37
UBA6
UBE3A
UBQLN1
UBQLN4
UNC45A
VCPIP1
VPS8
XAB2
YWHAQ
ZEB2
ZNF484
ZNF557
ZNF587
ZNF587B
ZNF592
ZNF83
ZSCAN4
80 interactors:
ADRM1
AFG3L1P
AFTPH
AHSP
ANXA1
APP
AR
ARC
ASAP3
ATG9A
BARD1
BLK
BPY2
BPY2B
BPY2C
BRCA1
C11orf49
CDKN1B
CEBPZ
DLG1
EAPP
EID1
EIF4G1
HBA1
HPCAL4
HSPA4
JADE1
KLHL38
LCK
MAGEA8
MCM7
MDM2
MEOX2
NDUFA13
NELFCD
NOMO2
PARVA
PDE1B
PGR
PML
POLE4
PRDX1
PSAP
PSMC3
PSMD4
RAD23A
RAD23B
RARA
RMI1
RNF2
SACS
SCAMP1
SCRIB
SGK223
SHBG
SMAD9
SOD1
SUMO3
TAT
TBC1D14
TCF19
TP53
TRIM65
TSC2
TTC3
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2G1
UBE2G2
UBE2L3
UBE2L6
UBQLN2
UCHL5
YOD1
YWHAE
YWHAZ
Entrez ID
4093
7337
HPRD ID
04484
03375
Ensembl ID
ENSG00000120693
ENSG00000114062
Uniprot IDs
O15198
Q05086
Q9BUI6
Q9H2G0
PDB IDs
1C4Z
1D5F
1EQX
2KR1
4GIZ
Enriched GO Terms of Interacting Partners
?
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Gene Expression
Cellular Metabolic Process
Transcription, DNA-templated
Biosynthetic Process
RNA Metabolic Process
RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Cellular Process
Cellular Protein Metabolic Process
Protein Metabolic Process
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Gastrulation
Anterior/posterior Pattern Specification
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Developmental Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Multicellular Organismal Development
Atrioventricular Valve Morphogenesis
Endoderm Development
Nitrogen Compound Metabolic Process
Formation Of Primary Germ Layer
Cell Differentiation
Atrioventricular Valve Development
Regulation Of Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
Transcription From RNA Polymerase II Promoter
Organ Development
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Metabolic Process
Embryo Development
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
SMAD Protein Complex Assembly
Posttranscriptional Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Pattern Specification Process
Protein Polyubiquitination
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Proteolysis
Positive Regulation Of Proteolysis
Protein Catabolic Process
Response To Stress
Cellular Response To Organic Substance
Regulation Of Mitotic Cell Cycle Phase Transition
Protein Modification By Small Protein Conjugation
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Cellular Protein Metabolic Process
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Cell Cycle
Regulation Of Protein Metabolic Process
Response To Organic Substance
Cellular Macromolecule Catabolic Process
Positive Regulation Of Cellular Metabolic Process
Protein Ubiquitination
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Protein Catabolic Process
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Metabolic Process
Regulation Of Mitotic Cell Cycle
DNA Damage Response, Signal Transduction By P53 Class Mediator
Mitotic Cell Cycle Checkpoint
Cell Death
Death
Cell Cycle Checkpoint
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Apoptotic Process
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Signal Transduction Involved In DNA Damage Checkpoint
Regulation Of Cell Cycle G1/S Phase Transition
Signal Transduction In Response To DNA Damage
Signal Transduction Involved In Cell Cycle Checkpoint
Regulation Of Cell Cycle Arrest
Programmed Cell Death
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Catalytic Activity
Proteasomal Protein Catabolic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Protein K48-linked Ubiquitination
Regulation Of Cell Cycle
Catabolic Process
Mitotic G1 DNA Damage Checkpoint
Mitotic G1/S Transition Checkpoint
Tagcloud
?
2h5
accompanies
anova
dynactin
gadd45a
gtf2h5
invites
keuls
macaques
malfunctioning
nbn1
ndd
ndds
newman
ovx
perimenopausal
presenilin1
proteosome
psen1
rad23a
raphe
scna
serotonin
speculation
subserving
symptomology
ube2d3
ubea5
ubiquinase
Tagcloud (Difference)
?
2h5
accompanies
anova
dynactin
gadd45a
gtf2h5
invites
keuls
macaques
malfunctioning
nbn1
ndd
ndds
newman
ovx
perimenopausal
presenilin1
proteosome
psen1
rad23a
raphe
scna
serotonin
speculation
subserving
symptomology
ube2d3
ubea5
ubiquinase
Tagcloud (Intersection)
?