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GRK2 and FBXO25
Number of citations of the paper that reports this interaction (PubMedID
23940030
)
41
Data Source:
BioGRID
(enzymatic study)
GRK2
FBXO25
Description
G protein-coupled receptor kinase 2
F-box protein 25
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Cilium
Membrane
Cytoplasmic Side Of Mitochondrial Outer Membrane
Cell Projection
Synapse
Presynapse
Postsynapse
Ubiquitin Ligase Complex
Nucleus
Nucleolus
Cytoplasm
SCF Ubiquitin Ligase Complex
Molecular Function
Nucleotide Binding
G Protein-coupled Receptor Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
G Protein-coupled Receptor Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Alpha-2A Adrenergic Receptor Binding
Edg-2 Lysophosphatidic Acid Receptor Binding
Beta-adrenergic Receptor Kinase Activity
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Biological Process
Regulation Of The Force Of Heart Contraction
Desensitization Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of The Force Of Heart Contraction By Chemical Signal
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Tachykinin Receptor Signaling Pathway
Heart Development
Viral Genome Replication
Receptor Internalization
Positive Regulation Of Catecholamine Secretion
Negative Regulation Of Striated Muscle Contraction
Symbiont Entry Into Host Cell
Cardiac Muscle Contraction
Negative Regulation Of Relaxation Of Smooth Muscle
Protein Ubiquitination
Pathways
Calmodulin induced events
G alpha (q) signalling events
G alpha (s) signalling events
Activation of SMO
Activation of SMO
Cargo recognition for clathrin-mediated endocytosis
Drugs
ATP
Diseases
GWAS
Neonatal cytokine/chemokine levels (fetal genetic effect) (
30134952
)
Nontraumatic osteonecrosis of the femoral head (
32701715
)
Interacting Genes
49 interacting genes:
ADRA2A
ADRB2
AGTR1
AKAP12
ARRB1
BDKRB2
CAPN2
CAV1
CCR4
CCR5
CSNK2B
EGF
EGFR
EPHA2
ERBB2
FBXO25
FPR1
FSHR
GIT1
GIT2
GNA15
GNAQ
GNB3
GRM1
HDAC6
KCNIP3
MAPK3
MC4R
MDM2
NCS1
OPRD1
PDC
PDCL
PDE6G
PEBP1
PIK3CG
PLCB1
PRKACA
PRKCA
PRKCB
PRKCD
PRKCG
RASGRF1
RCVRN
RHO
RPLP2
SNCA
SRC
TPM2
82 interacting genes:
ANKRD13A
APLF
AXL
BMX
BRME1
CDK5RAP2
CDK9
CENPB
CHLSN
CUL1
CXXC4
DCX
DDX42
DEPTOR
DNAJB2
DNAJC8
DYRK3
DYRK4
EGFR
EID3
EIF4E2
ELK1
EPN1
FKBP3
G3BP1
GRK2
GTF2B
GTF2IRD2
HIP1
HMCES
HP1BP3
IL21
ILRUN
ING3
IRS1
JHY
KDR
KRT8
LMCD1
LUC7L
MAT2B
NKX2-5
NSRP1
NUAK1
ODF2
ORC4
PADI4
PAK4
PCK1
PDGFRA
PIP4K2C
PPID
PPP1R8
PRKCA
PRKG2
PRR15
PRRG1
PSMD4
RABEP2
RBM8A
RHBDD1
RIOK3
RPAP3
RPS10
RPS6KB2
SAMHD1
SERBP1
SKP1
STAC
SYTL2
TBX5
TCEAL2
TCEANC
TCP10L
TMA7
TNIP2
TRUB1
TWF1
UBE2D3
UBQLN1
UBQLN2
WDSUB1
Entrez ID
156
26260
HPRD ID
00182
16439
Ensembl ID
ENSG00000173020
ENSG00000147364
Uniprot IDs
A0A0S2Z392
P25098
Q8TCJ0
PDB IDs
1BAK
3CIK
3KRW
3KRX
3V5W
4MK0
4PNK
5HE1
5UKK
5UKL
5UUU
5UVC
5WG3
5WG4
5WG5
6C2Y
6U7C
7K7L
7K7Z
7PWD
Enriched GO Terms of Interacting Partners
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G Protein-coupled Receptor Signaling Pathway
Regulation Of Cell Communication
Signal Transduction
Regulation Of Signaling
Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Plasma Membrane
Regulation Of Biological Quality
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
System Process
Positive Regulation Of Signal Transduction
Regulation Of G Protein-coupled Receptor Signaling Pathway
Regulation Of Multicellular Organismal Process
Modulation Of Chemical Synaptic Transmission
Enzyme Binding
Intracellular Signal Transduction
G Protein-coupled Receptor Activity
Regulation Of Transport
Epidermal Growth Factor Receptor Signaling Pathway
Intracellular Signaling Cassette
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Vesicle-mediated Transport
Response To Lipid
Cell Surface Receptor Signaling Pathway
ERBB2 Signaling Pathway
Nervous System Process
Response To Hormone
Response To Growth Factor
Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity
Regulation Of Locomotion
Positive Regulation Of Protein Localization
Regulation Of System Process
Positive Regulation Of Cell Migration
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Metal Ion Transport
Regulation Of Phosphorus Metabolic Process
Regulation Of Cellular Component Organization
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Protein Kinase C Signaling
Negative Regulation Of Catabolic Process
Cellular Response To Oxygen-containing Compound
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Proteolysis
Kinase Activity
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Nucleus
Polyubiquitin Modification-dependent Protein Binding
Cytosol
ATP Binding
Nucleotide Binding
Protein Phosphorylation
Phosphorylation
Protein Serine/threonine Kinase Activity
Apoptotic Process
Atrioventricular Node Cell Fate Commitment
Nucleoplasm
Cell Death
Programmed Cell Death
Cytoplasm
Protein Serine Kinase Activity
His-Purkinje System Cell Differentiation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Regulation Of Apoptotic Process
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Cardioblast Differentiation
Atrioventricular Node Cell Development
Bundle Of His Development
Vascular Endothelial Growth Factor Binding
Cellular Response To Stress
Regulation Of Programmed Cell Death
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Signal Transduction
Protein Metabolic Process
Vascular Endothelial Growth Factor Receptor Activity
Transferase Activity
Proteasomal Protein Catabolic Process
Cardiac Muscle Cell Fate Commitment
Cardiac Ventricle Formation
Negative Regulation Of Endothelial Cell Apoptotic Process
Ubiquitin Ligase Complex Scaffold Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Modification Process
Atrial Septum Development
Positive Regulation Of Natural Killer Cell Differentiation
Ubiquitin-modified Protein Reader Activity
ERAD Pathway
Regulation Of Cell Communication
Autophagosome Assembly
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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