GRK2 and PDCL

Number of citations of the paper that reports this interaction (PubMedID 10884381)
0

Data Source:
HPRD (in vitro)

		GRK2	PDCL
Description		G protein-coupled receptor kinase 2	phosducin like
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cilium Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Cell Projection Synapse Presynapse Postsynapse	Cytoplasm Cytosol Cilium Cell Projection
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity	Protein Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Viral Genome Replication Receptor Internalization Positive Regulation Of Catecholamine Secretion Negative Regulation Of Striated Muscle Contraction Symbiont Entry Into Host Cell Cardiac Muscle Contraction Negative Regulation Of Relaxation Of Smooth Muscle	Signal Transduction Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Positive Regulation Of Smoothened Signaling Pathway Heterotrimeric G-protein Complex Assembly
Pathways		Calmodulin induced events G alpha (q) signalling events G alpha (s) signalling events Activation of SMO Activation of SMO Cargo recognition for clathrin-mediated endocytosis	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs		ATP
Diseases
GWAS			Obesity-related traits ( 23251661)
Interacting Genes		49 interacting genes: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 ERBB2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB3 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PLCB1 PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2	10 interacting genes: CCT5 GNB1 GNGT1 GRK2 IKBKG LRRK2 MFHAS1 MRPL11 PSMC5 TCP1
Entrez ID		156	5082
HPRD ID		00182	05108
Ensembl ID		ENSG00000173020	ENSG00000136940
Uniprot IDs		A0A0S2Z392 P25098	Q13371
PDB IDs		1BAK 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1 5UKK 5UKL 5UUU 5UVC 5WG3 5WG4 5WG5 6C2Y 6U7C 7K7L 7K7Z 7PWD	8SFF 8SG8 8SGC 8SH9 8SHA 8SHF 8SHG 8SHL 8SHO 8SHP 8SHQ 8SHT
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction Regulation Of MAPK Cascade Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Plasma Membrane Regulation Of Biological Quality Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling System Process Positive Regulation Of Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Modulation Of Chemical Synaptic Transmission Enzyme Binding Intracellular Signal Transduction G Protein-coupled Receptor Activity Regulation Of Transport Epidermal Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Vesicle-mediated Transport Response To Lipid Cell Surface Receptor Signaling Pathway ERBB2 Signaling Pathway Nervous System Process Response To Hormone Response To Growth Factor Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Locomotion Positive Regulation Of Protein Localization Regulation Of System Process Positive Regulation Of Cell Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Metal Ion Transport Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Protein Kinase C Signaling Negative Regulation Of Catabolic Process Cellular Response To Oxygen-containing Compound Regulation Of ERK1 And ERK2 Cascade Regulation Of Proteolysis	Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Regulation Of Telomerase RNA Localization To Cajal Body G Protein-coupled Acetylcholine Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus Response To Catecholamine Photoreceptor Disc Membrane G-protein Beta-subunit Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Protein Localization To Nucleus Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Binding Of Sperm To Zona Pellucida Nucleotide Binding Signaling Receptor Complex Adaptor Activity Heterotrimeric G-protein Complex Positive Regulation Of Proteolysis ATP-dependent Protein Folding Chaperone Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Sperm-egg Recognition Acetylcholine Receptor Signaling Pathway Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Postsynaptic Signal Transduction Negative Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Protein Folding Chaperone Cell-cell Recognition Regulation Of Macrophage Activation Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Ubiquitin Protein Ligase Binding ATP Binding Photoreceptor Outer Segment GTPase Activity Positive Regulation Of Telomere Maintenance Edg-2 Lysophosphatidic Acid Receptor Binding Nuclear Proteasome Complex ATP Hydrolysis Activity Regulation Of Proteolysis Cell Body Regulation Of Protein Stability Regulation Of DNA Biosynthetic Process
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