GRK2 and PRKCB

Number of citations of the paper that reports this interaction (PubMedID 12679936)
18

Data Source:
HPRD (in vitro, in vivo)

		GRK2	PRKCB
Description		G protein-coupled receptor kinase 2	protein kinase C beta
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cilium Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Cell Projection Synapse Presynapse Postsynapse	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Spectrin Membrane Calyx Of Held Extracellular Exosome Presynaptic Cytosol
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity	Nucleotide Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Calcium Channel Regulator Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Histone H3T6 Kinase Activity Histone Binding Metal Ion Binding Nuclear Androgen Receptor Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Viral Genome Replication Receptor Internalization Positive Regulation Of Catecholamine Secretion Negative Regulation Of Striated Muscle Contraction Symbiont Entry Into Host Cell Cardiac Muscle Contraction Negative Regulation Of Relaxation Of Smooth Muscle	Adaptive Immune Response Immune System Process Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Calcium Ion Transport Intracellular Calcium Ion Homeostasis Apoptotic Process Mitotic Nuclear Membrane Disassembly Signal Transduction Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of D-glucose Transmembrane Transport Negative Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin Secretion Intracellular Signal Transduction B Cell Activation Lipoprotein Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Negative Regulation Of Insulin Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Transport Protein Kinase C Signaling Cellular Response To Carbohydrate Stimulus Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Vesicle Exocytosis
Pathways		Calmodulin induced events G alpha (q) signalling events G alpha (s) signalling events Activation of SMO Activation of SMO Cargo recognition for clathrin-mediated endocytosis	Disinhibition of SNARE formation Activation of NF-kappaB in B cells Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events Depolymerization of the Nuclear Lamina WNT5A-dependent internalization of FZD4 VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Response to elevated platelet cytosolic Ca2+ RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
Drugs		ATP	Vitamin E Tamoxifen Phosphorylcolamine Staurosporine Dequalinium Enzastaurin Ellagic acid Cholecystokinin Benzoyl peroxide alpha-Tocopherol succinate D-alpha-Tocopherol acetate
Diseases
GWAS			Blood protein levels ( 30072576) Bone mineral content ( 31790847) Cadmium levels ( 26025379) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Daytime nap ( 33568662) Gut microbiota relative abundance (Dorea) ( 33208821) Inflammatory bowel disease ( 23128233 28067908) Lymphocyte count ( 32888494) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Primary biliary cholangitis ( 28062665) Sleep duration ( 30531941) Systemic lupus erythematosus ( 33272962) Ulcerative colitis ( 28067908)
Interacting Genes		49 interacting genes: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 ERBB2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB3 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PLCB1 PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2	88 interacting genes: ACSL4 AFAP1 ANXA2 ANXA7 BLVRA BMPR2 BTK CARD11 CASR CD5 CHAT CHUK CISH CSF2RB CYTH2 DAB2 DVL2 EGFR EIF4E EIF6 EP300 EPB41 FBXO7 GABRB2 GABRG2 GAP43 GCNT1 GJA1 GNA12 GNA13 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A GSK3B H1-0 H1-1 H1-5 H3C1 HABP4 HSPA4 IBTK IFNAR2 IKBKB IKBKG ITGB2 ITGB7 KIT LIG1 LMNB1 LST1 MAPK6 MAPT MARCKS MBP MKI67 NCF1 NRGN NUMB PA2G4 PDLIM5 PDLIM7 PDPK1 PEBP1 PPP1CA PPP2CB PTPA PTPN11 RACK1 RASGRP3 RB1 RGS2 RIPK4 RRAD SDC2 SPTAN1 STXBP1 SYT6 TERF1 TIAM1 TINF2 TOP2A TRIM41 VTN YWHAG ZMYND8
Entrez ID		156	5579
HPRD ID		00182	01499
Ensembl ID		ENSG00000173020	ENSG00000166501
Uniprot IDs		A0A0S2Z392 P25098	P05771
PDB IDs		1BAK 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1 5UKK 5UKL 5UUU 5UVC 5WG3 5WG4 5WG5 6C2Y 6U7C 7K7L 7K7Z 7PWD	2I0E 8SG2
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction Regulation Of MAPK Cascade Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Plasma Membrane Regulation Of Biological Quality Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling System Process Positive Regulation Of Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Modulation Of Chemical Synaptic Transmission Enzyme Binding Intracellular Signal Transduction G Protein-coupled Receptor Activity Regulation Of Transport Epidermal Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Vesicle-mediated Transport Response To Lipid Cell Surface Receptor Signaling Pathway ERBB2 Signaling Pathway Nervous System Process Response To Hormone Response To Growth Factor Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Locomotion Positive Regulation Of Protein Localization Regulation Of System Process Positive Regulation Of Cell Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Metal Ion Transport Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Protein Kinase C Signaling Negative Regulation Of Catabolic Process Cellular Response To Oxygen-containing Compound Regulation Of ERK1 And ERK2 Cascade Regulation Of Proteolysis	Regulation Of Signaling Regulation Of Cellular Component Organization Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Intracellular Signaling Cassette Positive Regulation Of Cell Communication Regulation Of Developmental Process Cytoplasm Plasma Membrane Regulation Of Multicellular Organismal Process Positive Regulation Of Signal Transduction Regulation Of Biological Quality Developmental Process Regulation Of Postsynaptic Membrane Potential Regulation Of Synaptic Plasticity Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cellular Component Organization Focal Adhesion Regulation Of Cell Projection Organization Postsynapse Regulation Of Membrane Potential Cellular Response To Oxygen-containing Compound Protein Kinase Binding Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Cytosol Regulation Of Protein Localization Calmodulin Binding Positive Regulation Of Transport Regulation Of Transport Regulation Of System Process Regulation Of Cell Growth Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly Neuronal Cell Body Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Phospholipase Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Development Regulation Of DNA-binding Transcription Factor Activity IkappaB Kinase Complex Cellular Response To Interleukin-3 NMDA Glutamate Receptor Activity Glutamate Binding
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