FBXO25 and JHY

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		FBXO25	JHY
Description		F-box protein 25	junctional cadherin complex regulator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex	Extracellular Region
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Protein Ubiquitination	Brain Development Cell Projection Organization Cell Differentiation Axoneme Assembly Motile Cilium Assembly Establishment Of Localization In Cell Regulation Of Establishment Of Planar Polarity Cerebrospinal Fluid Circulation
Pathways
Drugs
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)	Femur bone mineral density x serum urate levels interaction ( 34046847) High density lipoprotein cholesterol levels ( 30498476)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	6 interacting genes: APP DAPK1 FBXO25 LRRK2 NEDD4 SRPK1
Entrez ID		26260	79864
HPRD ID		16439	08035
Ensembl ID		ENSG00000147364	ENSG00000109944
Uniprot IDs		Q8TCJ0	B3KUM2 Q6NUN7
PDB IDs
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly	Positive Regulation Of Catabolic Process Golgi-associated Vesicle Protein Metabolic Process Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Syntaxin-1 Binding Positive Regulation Of Protein Catabolic Process Protein Modification Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Synapse Organization Neuromuscular Junction Development Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Synapse Organization Regulation Of CAMP/PKA Signal Transduction Modulation Of Excitatory Postsynaptic Potential Response To Metal Ion Protein Phosphorylation Protein Serine Kinase Activity Regulation Of Protein Catabolic Process Regulation Of Autophagy Phosphorylation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Membrane Potential Amylin Binding Positive Regulation Of Toll Signaling Pathway Endocytosis Protein Serine/threonine Kinase Activity DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Formation Of Structure Involved In A Symbiotic Process Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Cell Junction Organization Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Calcium-mediated Signaling Protein Kinase Activity Defense Response Macromolecule Metabolic Process Acetylcholine Receptor Activator Activity Positive Regulation Of Programmed Cell Death Positive Regulation Of Tumor Necrosis Factor Production Lipoprotein Particle Positive Regulation Of Protein Import
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