FBXO25 and RPAP3

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		FBXO25	RPAP3
Description		F-box protein 25	RNA polymerase II associated protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex	Cytosol Cilium Ciliary Basal Body R2TP Complex Protein Folding Chaperone Complex RPAP3/R2TP/prefoldin-like Complex
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	Protein Binding
	Biological Process	Protein Ubiquitination	Protein Stabilization
Pathways
Drugs
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Cognitive performance (processing speed) ( 31598132) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Rosacea symptom severity ( 29771307) Vertical cup-disc ratio ( 25241763) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	11 interacting genes: APP DAPK1 FBXO25 HSP90AA1 HSPB1 ITCH LRRK2 MFHAS1 NEDD4 TERF1 TGFBR1
Entrez ID		26260	79657
HPRD ID		16439	07970
Ensembl ID		ENSG00000147364	ENSG00000005175
Uniprot IDs		Q8TCJ0	Q9H6T3
PDB IDs			4CGV 4CGW 6EZ4 6FD7 6FDP 6FDT 6FM8 6FO1 6GXZ 6ZBK
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly	Positive Regulation Of Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Regulation Of Protein Catabolic Process Response To Stress Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Defense Response Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Cellular Response To Manganese Ion Positive Regulation Of Metabolic Process Response To Other Organism Regulation Of Protein Modification Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Response To Manganese Ion Positive Regulation Of Tumor Necrosis Factor Production Protein Homodimerization Activity Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Golgi-associated Vesicle Response To External Biotic Stimulus Cellular Response To Catecholamine Stimulus Regulation Of Intracellular Signal Transduction GTP Binding Regulation Of Autophagy Syntaxin-1 Binding Protein Metabolic Process Response To Catecholamine Regulation Of Apoptotic Signaling Pathway Transmembrane Transporter Binding Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Telomere Maintenance Via Telomerase Regulation Of Defense Response Regulation Of Signal Transduction Regulation Of JNK Cascade Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization To Nucleus Negative Regulation Of Apoptotic Process RNA-templated DNA Biosynthetic Process Regulation Of Innate Immune Response Endocytosis Apoptotic Process Protein Refolding
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