FBXO25 and NUAK1

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		FBXO25	NUAK1
Description		F-box protein 25	NUAK family kinase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Ubiquitination	Protein Phosphorylation DNA Damage Response Cell Adhesion Regulation Of Cell Adhesion Regulation Of Cell Population Proliferation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cellular Senescence
Pathways			Regulation of TP53 Activity through Phosphorylation
Drugs			Fostamatinib
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)	Alzheimer's disease biomarkers ( 23419831) Attention function in attention deficit hyperactive disorder ( 26174813) Brain morphology (MOSTest) ( 32665545) General glucose level in pregnancy (gestational week 30-32) ( 30324795) Lateral ventricular volume in normal aging ( 30258056) Medial thalamic nuclei volume ( 34006833) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Two-hour glucose in pregnancy (gestational week 30-32) ( 30324795)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	5 interacting genes: APP CASP6 FBXO25 LATS1 PPP1CC
Entrez ID		26260	9891
HPRD ID		16439	12171
Ensembl ID		ENSG00000147364	ENSG00000074590
Uniprot IDs		Q8TCJ0	O60285
PDB IDs
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly	Protein Metabolic Process Negative Regulation Of Protein Localization To Nucleus Intracellular Signal Transduction Postsynapse Macromolecule Metabolic Process Nuclear Chromosome Segregation Sister Chromatid Segregation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Acetylcholine Receptor Activator Activity Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Component Organization PTB Domain Binding Regulation Of Synapse Assembly Positive Regulation Of Apoptotic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Programmed Cell Death Axon Midline Choice Point Recognition Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Postsynapse Organization Lipoprotein Particle Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Cellular Response To Staurosporine Microtubule Bundle Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Microtubule Organizing Center Chromosome Segregation Inner Cell Mass Cell Fate Commitment
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