FBXO25 and CXXC4

Number of citations of the paper that reports this interaction (PubMedID 20473970)
39

Data Source:
BioGRID (two hybrid)

		FBXO25	CXXC4
Description		F-box protein 25	CXXC finger protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex	Nucleus Cytoplasm Cytoplasmic Vesicle
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	DNA Binding Zinc Ion Binding Methyl-CpG Binding PDZ Domain Binding Metal Ion Binding
	Biological Process	Protein Ubiquitination	Zygotic Specification Of Dorsal/ventral Axis Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)	Chronotype ( 30696823) Heel bone mineral density x serum urate levels interaction ( 34046847) Menarche (age at onset) ( 27182965) Metabolite levels ( 23823483) Molybdenum levels ( 26025379) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	3 interacting genes: APP DVL1 FBXO25
Entrez ID		26260	80319
HPRD ID		16439	16773
Ensembl ID		ENSG00000147364	ENSG00000168772
Uniprot IDs		Q8TCJ0	A0A8V8TLX0 J9JIF5
PDB IDs
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly	Collateral Sprouting Neuronal Dense Core Vesicle Positive Regulation Of Excitatory Postsynaptic Potential Frizzled Binding Neuron Projection Organization Modulation Of Excitatory Postsynaptic Potential Regulation Of Membrane Potential Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Leukocyte Adhesion To Arterial Endothelial Cell Mitochondrial Manganese Ion Transmembrane Transport Zinc:bicarbonate Symporter Activity Iron Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Mercury Ion Transport Developmental Cell Growth Regulation Of Nervous System Process Acetylcholine Receptor Activator Activity Growth Cone Regulation Of Postsynapse Organization Lipoprotein Particle Positive Regulation Of Protein Import Dendritic Spine Developmental Growth Involved In Morphogenesis Positive Regulation Of Protein Localization To Presynapse Axonogenesis PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Convergent Extension Involved In Neural Plate Elongation Cellular Detoxification Of Cadmium Ion Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Catabolic Process Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Monoatomic Cation:bicarbonate Symporter Activity Cartilage Homeostasis Presynapse
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