FBXO25 and PRRG1

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		FBXO25	PRRG1
Description		F-box protein 25	proline rich and Gla domain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Protein Ubiquitination	Proteolysis Blood Coagulation
Pathways
Drugs
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	3 interacting genes: FBXO25 NEDD4L UQCRH
Entrez ID		26260	5638
HPRD ID		16439	05113
Ensembl ID		ENSG00000147364	ENSG00000130962
Uniprot IDs		Q8TCJ0	O14668 Q8NEK6
PDB IDs
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly	Respiratory Chain Complex III Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Quinol-cytochrome-c Reductase Activity Respiratory Chain Complex Sodium Channel Inhibitor Activity Negative Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Caveolin-mediated Endocytosis Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Monoatomic Cation Transmembrane Transport Oxidative Phosphorylation Inorganic Cation Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Dendrite Extension Protein Ubiquitination Sodium Ion Import Across Plasma Membrane Inorganic Ion Transmembrane Transport Protein Modification By Small Protein Conjugation Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Neuromuscular Junction Development Regulation Of Sodium Ion Transmembrane Transport Post-translational Protein Modification Sodium Channel Regulator Activity Regulation Of Protein Localization To Cell Surface Regulation Of Membrane Repolarization Negative Regulation Of Potassium Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Monoatomic Ion Transport Receptor Metabolic Process Multivesicular Body Regulation Of Membrane Depolarization Protein Monoubiquitination Regulation Of Dendrite Morphogenesis SCF Ubiquitin Ligase Complex Transmembrane Transport Receptor Internalization Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Aerobic Electron Transport Chain
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