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FBXO25 and ELK1
Number of citations of the paper that reports this interaction (PMID
23940030
)
0
Data Source:
BioGRID
(enzymatic study)
FBXO25
ELK1
Gene Name
F-box protein 25
ELK1, member of ETS oncogene family
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleolus
SCF Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Mitochondrion
Dendrite
Neuronal Cell Body
Axon Terminus
Molecular Function
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
Core Promoter Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
Chromatin Binding
Double-stranded DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Biological Process
Protein Ubiquitination
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Transcription From RNA Polymerase II Promoter
Response To Light Stimulus
Cell Differentiation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Neurotrophin TRK Receptor Signaling Pathway
Stress-activated MAPK Cascade
Cellular Response To Testosterone Stimulus
Cellular Response To Gamma Radiation
Positive Regulation Of Neuron Death
Pathways
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
ERK/MAPK targets
Innate Immune System
Signalling by NGF
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 3 (TLR3) Cascade
ERK/MAPK targets
Toll Like Receptor 4 (TLR4) Cascade
MAPK targets/ Nuclear events mediated by MAP kinases
Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions
80 interactors:
ADRBK1
ANKRD13A
APLF
AXL
BMX
C11orf63
C19orf57
C6orf106
C7orf50
CDK5RAP2
CDK9
CENPB
CUL1
CXXC4
DCX
DDX42
DEPTOR
DNAJB2
DNAJC8
DYRK3
DYRK4
EGFR
EID3
EIF4E2
ELK1
EPN1
FKBP3
G3BP1
GTF2B
GTF2IRD2
HIP1
HMCES
HP1BP3
IL21
ING3
IRS1
KDR
KRT8
LMCD1
LUC7L
MAT2B
NSRP1
NUAK1
ODF2
ORC4
PADI4
PAK4
PCK1
PDGFRA
PIP4K2C
PPID
PPP1R8
PRKCA
PRKG2
PRR15
PRRG1
PSMD4
RABEP2
RBM8A
RHBDD1
RIOK3
RPAP3
RPS10
RPS6KB2
SAMHD1
SERBP1
SKP1
STAC
SYTL2
TCEAL2
TCEANC
TCP10L
TMA7
TNIP2
TRUB1
TWF1
UBE2D3
UBQLN1
UBQLN2
WDSUB1
38 interactors:
APP
BRCA1
CDK6
CEBPB
CREBBP
EMX1
EP300
EWSR1
FBXO25
FLI1
FOS
GRB10
GRB2
HDAC1
HOXB13
ID1
ID2
ID3
KLF4
MAD2L2
MAP2K1
MAP2K3
MAPK1
MAPK10
MAPK11
MAPK14
MAPK3
MAPK8
MAPK9
MOB4
PIAS2
SNCA
SRF
STARD3NL
STK16
TAOK2
UBC
UBE2I
Entrez ID
26260
2002
HPRD ID
16439
02407
Ensembl ID
ENSG00000147364
ENSG00000126767
Uniprot IDs
Q8TCJ0
P19419
Q86SR6
PDB IDs
1DUX
Enriched GO Terms of Interacting Partners
?
Regulation Of Metabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Peptidyl-amino Acid Modification
Cellular Metabolic Process
Cellular Protein Modification Process
Enzyme Linked Receptor Protein Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Response To Stress
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Innate Immune Response
Neurotrophin Signaling Pathway
Viral Process
Protein Phosphorylation
Cellular Response To Stimulus
Cellular Response To Growth Factor Stimulus
Fibroblast Growth Factor Receptor Signaling Pathway
Cellular Protein Metabolic Process
Response To Growth Factor
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Gene Expression
Peptidyl-tyrosine Phosphorylation
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Positive Regulation Of Phospholipase C Activity
Phosphorylation
Intracellular Signal Transduction
Regulation Of Cellular Process
Rhythmic Process
Protein Autophosphorylation
Positive Regulation Of Phospholipase Activity
Response To Stimulus
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Organic Substance
Immune Response
Proteasomal Protein Catabolic Process
G1/S Transition Of Mitotic Cell Cycle
Response To UV-A
Peptidyl-serine Autophosphorylation
Regulation Of Phospholipase Activity
Apoptotic Process
Positive Regulation Of Lipase Activity
Defense Response
Protein Metabolic Process
Regulation Of Cell Death
Immune System Process
Programmed Cell Death
Regulation Of Cellular Protein Metabolic Process
Cellular Macromolecule Catabolic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Stress-activated MAPK Cascade
Positive Regulation Of Metabolic Process
Stress-activated Protein Kinase Signaling Cascade
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Toll-like Receptor Signaling Pathway
Regulation Of RNA Biosynthetic Process
Cellular Response To Stress
Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Macromolecule Biosynthetic Process
MAPK Cascade
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Metabolic Process
Regulation Of Signaling
Regulation Of Signal Transduction
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Innate Immune Response
Signal Transduction By Phosphorylation
Response To Growth Factor
Innate Immune Response
Response To Stress
Immune System Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Innate Immune Response
Cellular Response To Organic Substance
Transcription, DNA-templated
Immune Response
Regulation Of Phosphorylation
RNA Biosynthetic Process
Tagcloud
?
activate
activated
atf2
hearts
hypertrophic
ischemia
jnk
jun
kd
mapk
mapkapk2
mapks
mekk1
myocyte
myocytes
perfused
reactivating
reperfusion
rk
sapks
sek1
speculate
stimulates
stresses
subfamily
superfamily
transactivating
transfection
ventricular
Tagcloud (Difference)
?
activate
activated
atf2
hearts
hypertrophic
ischemia
jnk
jun
kd
mapk
mapkapk2
mapks
mekk1
myocyte
myocytes
perfused
reactivating
reperfusion
rk
sapks
sek1
speculate
stimulates
stresses
subfamily
superfamily
transactivating
transfection
ventricular
Tagcloud (Intersection)
?