FBXO25 and PPP1R8

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		FBXO25	PPP1R8
Description		F-box protein 25	protein phosphatase 1 regulatory subunit 8
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Nuclear Speck
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	DNA Binding RNA Binding MRNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Ribonuclease E Activity Hydrolase Activity Protein Phosphatase Regulator Activity Molecular Function Inhibitor Activity
	Biological Process	Protein Ubiquitination	MRNA Processing RNA Catabolic Process Cell Population Proliferation RNA Splicing
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	28 interacting genes: APP APPBP2 CDC5L CNKSR1 CREBBP CRMP1 CSNK2A1 CSNK2A2 CTNNBL1 EED ERG28 FBXO25 GBP2 HDAC2 HMGA1 LRRK2 LYN MELK PPIL1 PPP1CA PPP1CC PRKACA RBM48 RTN4IP1 SETDB1 SF3B1 STC2 WDR77
Entrez ID		26260	5511
HPRD ID		16439	04028
Ensembl ID		ENSG00000147364	ENSG00000117751
Uniprot IDs		Q8TCJ0	Q12972 Q6ICT4
PDB IDs			3V4Y
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly	Macromolecule Metabolic Process Nucleoplasm Postsynapse Cellular Response To Catecholamine Stimulus Response To Catecholamine Protein Modification Process Protein Kinase CK2 Complex Intracellular Signal Transduction Protein Metabolic Process Spliceosomal Complex Cellular Response To Stress Regulation Of Proteolysis Enzyme Binding MRNA Metabolic Process Rhythmic Process Cellular Response To Dopamine PTW/PP1 Phosphatase Complex Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Signaling Receptor Activator Activity Nucleobase-containing Compound Metabolic Process MRNA Processing Response To Dopamine Cellular Response To Heat Perikaryon Cellular Response To Manganese Ion Chromatin Binding Protein Kinase Activity DNA Repair Positive Regulation Of Gliogenesis Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Circadian Regulation Of Gene Expression DNA Damage Response Positive Regulation Of Programmed Cell Death Nucleus Response To Manganese Ion Prp19 Complex Protein Serine Kinase Activity Golgi-associated Vesicle Chromatin Organization Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process RNA Splicing MRNA Splicing, Via Spliceosome Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macroautophagy ESC/E(Z) Complex Negative Regulation Of Gene Expression
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