FBXO25 and DEPTOR

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		FBXO25	DEPTOR
Description		F-box protein 25	DEP domain containing MTOR interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex	Lysosome Lysosomal Membrane Plasma Membrane Membrane
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Lipid Binding Protein Serine/threonine Kinase Inhibitor Activity Phosphatidic Acid Binding
	Biological Process	Protein Ubiquitination	Autophagosome Assembly Negative Regulation Of Protein Kinase Activity G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Cell Size Negative Regulation Of TORC2 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)	A body shape index ( 34021172) Choroid plexus volume ( 31530798) Depressive and manic episodes in bipolar disorder ( 26297903) Depressive episodes in bipolar disorder ( 26297903) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Idiopathic pulmonary fibrosis ( 31710517) Platelet count ( 32888494) Plateletcrit ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	13 interacting genes: ANKRD11 APP CCDC110 CHKA CUL5 FBXO25 LNX1 MAPK3 PSME3 RPS6KA1 RPS6KB1 TRAF1 TRIM41
Entrez ID		26260	64798
HPRD ID		16439	13137
Ensembl ID		ENSG00000147364	ENSG00000155792
Uniprot IDs		Q8TCJ0	Q8TB45
PDB IDs			7DKL 7OWG 7PE7 7PE8 7PE9 7PEA 7PEB 7PEC 7PED
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly	Regulation Of Extrinsic Apoptotic Signaling Pathway TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling Cytosol Identical Protein Binding Protein Modification Process Face Development ERBB2 Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of TOR Signaling Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of Signal Transduction Positive Regulation Of Defense Response Apoptotic Process Protein Metabolic Process Programmed Cell Death Negative Regulation Of Signaling Cell Death Negative Regulation Of Cell Communication Regulation Of Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Choline Kinase Activity Kinase Activity Cellular Response To Nutrient Levels SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Ubiquitination Transferase Activity SCF Ubiquitin Ligase Complex Glial Cell Development Negative Regulation Of TORC1 Signaling Acetylcholine Receptor Activator Activity Lipoprotein Particle Regulation Of Cell Communication Positive Regulation Of Protein Import Regulation Of Signaling ERBB Signaling Pathway Protein Modification By Small Protein Conjugation Symbiont-mediated Suppression Of Host Innate Immune Response PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Growth Factor Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production
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