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FBXO25 and KRT8
Number of citations of the paper that reports this interaction (PubMedID
23940030
)
41
Data Source:
BioGRID
(enzymatic study)
FBXO25
KRT8
Description
F-box protein 25
keratin 8
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleolus
Cytoplasm
SCF Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Intermediate Filament
Cell-cell Junction
Apicolateral Plasma Membrane
Nuclear Matrix
Z Disc
Sarcolemma
Keratin Filament
Intermediate Filament Cytoskeleton
Extracellular Exosome
Cell Periphery
Molecular Function
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Protein Binding
Scaffold Protein Binding
Biological Process
Protein Ubiquitination
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Other Organism
Cell Differentiation Involved In Embryonic Placenta Development
Extrinsic Apoptotic Signaling Pathway
Hepatocyte Apoptotic Process
Pathways
Keratinization
Formation of the cornified envelope
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Alveolar Cells
Drugs
Tenecteplase
Lanoteplase
Copper
Diseases
GWAS
Neonatal cytokine/chemokine levels (fetal genetic effect) (
30134952
)
Nontraumatic osteonecrosis of the femoral head (
32701715
)
Alanine aminotransferase levels (
33339817
33547301
34315874
)
Aspartate aminotransferase levels (
33547301
34315874
)
Cancer (pleiotropy) (
27197191
)
Gamma glutamyl transferase levels (
29403010
)
Mean reticulocyte volume (
32888494
)
Opioid dependence (time to event) (
34124712
)
Prostate cancer (
21743057
)
Sick sinus syndrome (
33580673
)
Interacting Genes
82 interacting genes:
ANKRD13A
APLF
AXL
BMX
BRME1
CDK5RAP2
CDK9
CENPB
CHLSN
CUL1
CXXC4
DCX
DDX42
DEPTOR
DNAJB2
DNAJC8
DYRK3
DYRK4
EGFR
EID3
EIF4E2
ELK1
EPN1
FKBP3
G3BP1
GRK2
GTF2B
GTF2IRD2
HIP1
HMCES
HP1BP3
IL21
ILRUN
ING3
IRS1
JHY
KDR
KRT8
LMCD1
LUC7L
MAT2B
NKX2-5
NSRP1
NUAK1
ODF2
ORC4
PADI4
PAK4
PCK1
PDGFRA
PIP4K2C
PPID
PPP1R8
PRKCA
PRKG2
PRR15
PRRG1
PSMD4
RABEP2
RBM8A
RHBDD1
RIOK3
RPAP3
RPS10
RPS6KB2
SAMHD1
SERBP1
SKP1
STAC
SYTL2
TBX5
TCEAL2
TCEANC
TCP10L
TMA7
TNIP2
TRUB1
TWF1
UBE2D3
UBQLN1
UBQLN2
WDSUB1
53 interacting genes:
ANXA1
BYSL
CEP57
CLK1
DEDD
DMD
EGFR
ESR1
FBXO25
FGFR3
GRB2
HSPA5
IKBKG
KIFC3
KPNA2
KRT13
KRT15
KRT16
KRT18
KRT24
KRT25
KRT26
KRT27
KRT28
KRT31
KRT32
KRT33B
KRT35
KRT36
KRT37
KRT38
KRT40
LINC01554
MAPK1
MAPK14
MAPK3
MAPK8
NEK6
OGT
PIWIL2
PKD1
PKP1
PLAT
PNN
PPL
QRSL1
RAF1
SUMO2
TCHP
TFIP11
TRIM54
TROAP
WBP2
Entrez ID
26260
3856
HPRD ID
16439
01015
Ensembl ID
ENSG00000147364
ENSG00000170421
Uniprot IDs
Q8TCJ0
P05787
Q7L4M3
PDB IDs
7K3C
7K3X
7K3Y
Enriched GO Terms of Interacting Partners
?
Kinase Activity
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Nucleus
Polyubiquitin Modification-dependent Protein Binding
Cytosol
ATP Binding
Nucleotide Binding
Protein Phosphorylation
Phosphorylation
Protein Serine/threonine Kinase Activity
Apoptotic Process
Atrioventricular Node Cell Fate Commitment
Nucleoplasm
Cell Death
Programmed Cell Death
Cytoplasm
Protein Serine Kinase Activity
His-Purkinje System Cell Differentiation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Regulation Of Apoptotic Process
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Cardioblast Differentiation
Atrioventricular Node Cell Development
Bundle Of His Development
Vascular Endothelial Growth Factor Binding
Cellular Response To Stress
Regulation Of Programmed Cell Death
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Signal Transduction
Protein Metabolic Process
Vascular Endothelial Growth Factor Receptor Activity
Transferase Activity
Proteasomal Protein Catabolic Process
Cardiac Muscle Cell Fate Commitment
Cardiac Ventricle Formation
Negative Regulation Of Endothelial Cell Apoptotic Process
Ubiquitin Ligase Complex Scaffold Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Modification Process
Atrial Septum Development
Positive Regulation Of Natural Killer Cell Differentiation
Ubiquitin-modified Protein Reader Activity
ERAD Pathway
Regulation Of Cell Communication
Autophagosome Assembly
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Structural Constituent Of Skin Epidermis
Keratin Filament
Intermediate Filament Organization
Intermediate Filament
Structural Molecule Activity
Morphogenesis Of An Epithelium
Tissue Morphogenesis
Epithelial Cell Differentiation
Cytoskeleton Organization
Cytoskeleton
Supramolecular Fiber Organization
Anatomical Structure Morphogenesis
Cellular Developmental Process
Cell Differentiation
Organelle Organization
Developmental Process
Cytosol
Extracellular Exosome
MAP Kinase Activity
Schwann Cell Development
Stress-activated MAPK Cascade
ERBB2 Signaling Pathway
Stress-activated Protein Kinase Signaling Cascade
Desmosome
ERBB3 Signaling Pathway
ERBB2-ERBB3 Signaling Pathway
Response To Mechanical Stimulus
Insulin-like Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
MAPK Cascade
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Hair Cycle
Regulation Of Protein Metabolic Process
Intracellular Signaling Cassette
Tissue Development
Structural Constituent Of Cytoskeleton
Pseudopodium
Protein Kinase Activity
Interleukin-34-mediated Signaling Pathway
Cornified Envelope
Protein Binding
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cyclase Activity
Face Development
Epidermal Growth Factor Receptor Signaling Pathway
Glial Cell Development
Regulation Of Golgi Inheritance
Response To Muscle Stretch
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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