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FBXO25 and IL21
Number of citations of the paper that reports this interaction (PMID
23940030
)
0
Data Source:
BioGRID
(enzymatic study)
FBXO25
IL21
Gene Name
F-box protein 25
interleukin 21
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleolus
SCF Ubiquitin Ligase Complex
Extracellular Space
Molecular Function
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Cytokine Activity
Cytokine Receptor Binding
Interleukin-2 Receptor Binding
Biological Process
Protein Ubiquitination
Positive Regulation Of Natural Killer Cell Cytokine Production
Immune Response
Signal Transduction
Positive Regulation Of Cell Proliferation
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Natural Killer Cell Differentiation
Positive Regulation Of Tissue Remodeling
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Positive Regulation Of Interferon-gamma Biosynthetic Process
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Cell Maturation
Positive Regulation Of Inflammatory Response
Pathways
Drugs
Diseases
GWAS
Alopecia areata (
20596022
)
Celiac disease (
20190752
17558408
18311140
)
Inflammatory bowel disease (
23128233
)
Progressive supranuclear palsy (
21685912
)
Rheumatoid arthritis (
20453842
)
Ulcerative colitis (
21297633
)
Protein-Protein Interactions
80 interactors:
ADRBK1
ANKRD13A
APLF
AXL
BMX
C11orf63
C19orf57
C6orf106
C7orf50
CDK5RAP2
CDK9
CENPB
CUL1
CXXC4
DCX
DDX42
DEPTOR
DNAJB2
DNAJC8
DYRK3
DYRK4
EGFR
EID3
EIF4E2
ELK1
EPN1
FKBP3
G3BP1
GTF2B
GTF2IRD2
HIP1
HMCES
HP1BP3
IL21
ING3
IRS1
KDR
KRT8
LMCD1
LUC7L
MAT2B
NSRP1
NUAK1
ODF2
ORC4
PADI4
PAK4
PCK1
PDGFRA
PIP4K2C
PPID
PPP1R8
PRKCA
PRKG2
PRR15
PRRG1
PSMD4
RABEP2
RBM8A
RHBDD1
RIOK3
RPAP3
RPS10
RPS6KB2
SAMHD1
SERBP1
SKP1
STAC
SYTL2
TCEAL2
TCEANC
TCP10L
TMA7
TNIP2
TRUB1
TWF1
UBE2D3
UBQLN1
UBQLN2
WDSUB1
3 interactors:
DGKA
FBXO25
IL21R
Entrez ID
26260
59067
HPRD ID
16439
05650
Ensembl ID
ENSG00000147364
ENSG00000138684
Uniprot IDs
Q8TCJ0
Q9HBE4
PDB IDs
2OQP
3TGX
Enriched GO Terms of Interacting Partners
?
Regulation Of Metabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Peptidyl-amino Acid Modification
Cellular Metabolic Process
Cellular Protein Modification Process
Enzyme Linked Receptor Protein Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Response To Stress
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Innate Immune Response
Neurotrophin Signaling Pathway
Viral Process
Protein Phosphorylation
Cellular Response To Stimulus
Cellular Response To Growth Factor Stimulus
Fibroblast Growth Factor Receptor Signaling Pathway
Cellular Protein Metabolic Process
Response To Growth Factor
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Gene Expression
Peptidyl-tyrosine Phosphorylation
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Positive Regulation Of Phospholipase C Activity
Phosphorylation
Intracellular Signal Transduction
Regulation Of Cellular Process
Rhythmic Process
Protein Autophosphorylation
Positive Regulation Of Phospholipase Activity
Response To Stimulus
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Organic Substance
Immune Response
Proteasomal Protein Catabolic Process
G1/S Transition Of Mitotic Cell Cycle
Response To UV-A
Peptidyl-serine Autophosphorylation
Regulation Of Phospholipase Activity
Apoptotic Process
Positive Regulation Of Lipase Activity
Defense Response
Protein Metabolic Process
Regulation Of Cell Death
Immune System Process
Programmed Cell Death
Regulation Of Cellular Protein Metabolic Process
Cellular Macromolecule Catabolic Process
Interleukin-21-mediated Signaling Pathway
Cell Activation
Tagcloud
?
6r
adeno
adenocarcinoma
auto
batf
carrying
cd25
ctla4
folr4
foxp
foxp3
icos
il10
il6r
intranasal
lag3
leucine
lung
lungs
orphan
pstat3
rorc
rorgammat
specification
squamous
th17
transducer
tumoural
zipper
Tagcloud (Difference)
?
6r
adeno
adenocarcinoma
auto
batf
carrying
cd25
ctla4
folr4
foxp
foxp3
icos
il10
il6r
intranasal
lag3
leucine
lung
lungs
orphan
pstat3
rorc
rorgammat
specification
squamous
th17
transducer
tumoural
zipper
Tagcloud (Intersection)
?