ADRBK1 and CAV1

Number of citations of the paper that reports this interaction (PMID 10085129)
37

Data Source:
HPRD (in vitro)

		ADRBK1	CAV1
Gene Name		adrenergic, beta, receptor kinase 1	caveolin 1, caveolae protein, 22kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Primary Cilium	Golgi Membrane Acrosomal Membrane Intracellular Endosome Endoplasmic Reticulum Lipid Particle Plasma Membrane Integral Component Of Plasma Membrane Caveola Focal Adhesion Cilium Cell Cortex Basolateral Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Protein Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Binding ATP Binding Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity	Receptor Binding Patched Binding Structural Molecule Activity Protein Binding Cholesterol Binding Peptidase Activator Activity Enzyme Binding Protein Kinase Binding Protein Complex Scaffold Identical Protein Binding Ion Channel Binding Nitric-oxide Synthase Binding Inward Rectifier Potassium Channel Inhibitor Activity
	Biological Process	Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Fibroblast Growth Factor Receptor Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Receptor Internalization Positive Regulation Of Catecholamine Secretion Termination Of G-protein Coupled Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Striated Muscle Contraction Neurotrophin TRK Receptor Signaling Pathway Cardiac Muscle Contraction	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Inactivation Of MAPK Activity Angiogenesis Vasculogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Response To Ischemia Regulation Of The Force Of Heart Contraction By Chemical Signal Triglyceride Metabolic Process Calcium Ion Transport Cellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Skeletal Muscle Tissue Development Lactation Blood Coagulation Protein Localization Cellular Response To Starvation Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Peptidase Activity Viral Process Vesicle Organization Regulation Of Fatty Acid Metabolic Process Lipid Storage Regulation Of Blood Coagulation Cholesterol Transport Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Mammary Gland Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Maintenance Of Protein Location In Cell Response To Progesterone Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Nitric Oxide Homeostasis Vasoconstriction Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Cholesterol Homeostasis Negative Regulation Of MAPK Cascade Response To Estrogen Small Molecule Metabolic Process Protein Localization To Plasma Membrane Raft Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Vasoconstriction Nitric Oxide Metabolic Process Negative Regulation Of JAK-STAT Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Metalloenzyme Activity Leukocyte Migration Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Nitric-oxide Synthase Activity Protein Homooligomerization Cytosolic Calcium Ion Homeostasis Response To Calcium Ion Membrane Depolarization Regulation Of Peptidase Activity Calcium Ion Homeostasis Mammary Gland Involution Negative Regulation Of Protein Tyrosine Kinase Activity Caveola Assembly Cellular Response To Hyperoxia Caveolin-mediated Endocytosis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Membrane Repolarization During Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Inward Rectifier Potassium Channel Activity Protein Localization To Basolateral Plasma Membrane Receptor Internalization Involved In Canonical Wnt Signaling Pathway Negative Regulation Of Anoikis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		G alpha (q) signalling events Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Hedgehog 'on' state Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Calmodulin induced events Signalling by NGF DAP12 interactions PLC beta mediated events Opioid Signalling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Calmodulin induced events Downstream signal transduction PLC-gamma1 signalling Signaling by Hedgehog Signaling by EGFR in Cancer Activation of SMO	Metabolism of lipids and lipoproteins misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Lipid digestion, mobilization, and transport Signaling by Wnt Basigin interactions VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall eNOS activation disassembly of the destruction complex and recruitment of AXIN to the membrane Metabolism of nitric oxide Signaling by VEGF TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis NOSTRIN mediated eNOS trafficking VEGFR2 mediated vascular permeability XAV939 inhibits tankyrase, stabilizing AXIN eNOS activation and regulation Signaling by WNT in cancer
Drugs		Adenosine triphosphate
Diseases
GWAS			Atrial fibrillation ( 22544366) Electrocardiographic traits ( 20062063) Glaucoma (primary open-angle) ( 20835238) PR interval ( 20062060 23139255)
Protein-Protein Interactions		47 interactors: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB1 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2	81 interactors: ABCB1 ABL1 ADRBK1 AKAP1 APP AR BMX BSG BST1 BTK CAV2 CD40 CSK CSNK2A1 CSNK2A2 DAG1 DNM1 EDNRB EGFR ERBB2 ESR1 FLNA FLOT2 FYN GJA1 GJA3 GJB2 GNAI2 GRB7 GRK1 GRK5 HRAS HTR1F IGF1R IGFBP3 ILK INSR IRS1 KDR LATS1 LRP1 MALL MAPK1 MAPK3 MMP14 NEU3 NGFR NOS2 NOS3 NTRK1 PDGFRA PDGFRB PLD1 PLD2 PPP1CA PPP2CA PRNP PTEN PTGS2 PTPN1 PTPN11 PTPN6 PTPRF RAC1 RCVRN RHOA RHOC S1PR1 SCP2 SNCA SOS1 SRC STOML3 STRN STRN4 TGFBR1 TNFRSF1B TRAF2 TRAF6 TRPC1 VCP
Entrez ID		156	857
HPRD ID		00182	03028
Ensembl ID		ENSG00000173020	ENSG00000105974
Uniprot IDs		P25098	A9XTE5 Q03135 Q2TNI1 Q59E85 Q7Z4F3
PDB IDs		1BAK 3CIK 3KRW 3KRX 3V5W
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Cell Communication Signaling Platelet Activation Signal Transduction Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To External Stimulus Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Regulation Of Signaling Positive Regulation Of Metabolic Process Blood Coagulation Hemostasis Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Cell Activation Regulation Of Body Fluid Levels Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Wound Healing Cellular Calcium Ion Homeostasis Regulation Of Metabolic Process Calcium Ion Homeostasis Positive Regulation Of Cellular Metabolic Process Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cytosolic Calcium Ion Homeostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase Activity Response To Wounding	Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Signal Transduction Locomotion Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Response To External Stimulus Response To Stimulus Response To Organic Substance Cellular Response To Stimulus Regulation Of Cell Proliferation Regulation Of Phosphorylation Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Wound Healing Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Response To Wounding Positive Regulation Of Phosphorylation Cell Development Regulation Of Catalytic Activity Developmental Process Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Kinase Activity Regulation Of Body Fluid Levels Chemotaxis Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Catalytic Activity Blood Coagulation Anatomical Structure Development Hemostasis Cellular Response To Growth Factor Stimulus Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Tissue Development Intracellular Signal Transduction Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway System Development Neurotrophin Signaling Pathway Neuron Projection Morphogenesis Response To Stress Cell Morphogenesis Involved In Neuron Differentiation
Tagcloud ?		adrenergic adverse antihypertensive atenolol bp diastolic gln41leu grk2 grk5 grks hydrochlorothiazide hypertensives infarction leu41 leukocyte lymphoblastoid mmhg pharmacogenomic protects rs1894111 sequenced snp snps sr substudy systolic trandolapril verapamil whites	17beta caveolae caveolin cgg cingulate copyright coupling demonstration electrophysiological eralpha facilitation fear fmr1 fmrp fragile fxs glua1 inherited interacted ko plasticity potentiation raft recording rescued reserved retardation rights shrna
Tagcloud (Difference) ?		adrenergic adverse antihypertensive atenolol bp diastolic gln41leu grk2 grk5 grks hydrochlorothiazide hypertensives infarction leu41 leukocyte lymphoblastoid mmhg pharmacogenomic protects rs1894111 sequenced snp snps sr substudy systolic trandolapril verapamil whites	17beta caveolae caveolin cgg cingulate copyright coupling demonstration electrophysiological eralpha facilitation fear fmr1 fmrp fragile fxs glua1 inherited interacted ko plasticity potentiation raft recording rescued reserved retardation rights shrna
Tagcloud (Intersection) ?