FBXO25 and DNAJC8

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		FBXO25	DNAJC8
Description		F-box protein 25	DnaJ heat shock protein family (Hsp40) member C8
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytosol Intercellular Bridge
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	Protein Binding Hsp70 Protein Binding
	Biological Process	Protein Ubiquitination
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)	Aspartate aminotransferase levels ( 33547301) Hematocrit ( 32888494)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	9 interacting genes: AGTR1 APP CEBPA FBXO25 HMGA1 IKBKG RPL34 SRPK1 SRPK2
Entrez ID		26260	22826
HPRD ID		16439	13236
Ensembl ID		ENSG00000147364	ENSG00000126698
Uniprot IDs		Q8TCJ0	O75937
PDB IDs			7VPX
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly	Intracellular Signal Transduction Defense Response Protein-containing Complex Organization Protein Heterodimerization Activity Intracellular Signaling Cassette Positive Regulation Of Inflammatory Response Molecular Function Activator Activity Positive Regulation Of Viral Genome Replication Positive Regulation Of Proteolysis Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Stress Innate Immune Response Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Reactive Oxygen Species Metabolic Process Angiotensin Type I Receptor Activity Amyloid-beta Complex Growth Cone Lamellipodium Defense Response To Symbiont Regulation Of Response To Calcium Ion Defense Response To Other Organism Amylin Binding Positive Regulation Of Toll Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Viral Process Chromatin Organization Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Regulation Of Cell Population Proliferation Signal Transduction Regulation Of Inflammatory Response Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Positive Regulation Of Defense Response Renin-angiotensin Regulation Of Aldosterone Production Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development
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