GRK2 and RHO

Number of citations of the paper that reports this interaction (PubMedID 10722682)
0

Data Source:
HPRD (in vitro)

		GRK2	RHO
Description		G protein-coupled receptor kinase 2	rhodopsin
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cilium Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Cell Projection Synapse Presynapse Postsynapse	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Golgi Apparatus Plasma Membrane Cell-cell Junction Membrane Golgi-associated Vesicle Membrane Photoreceptor Outer Segment Membrane Cell Projection Ciliary Membrane Photoreceptor Inner Segment Membrane Sperm Midpiece Photoreceptor Disc Membrane Rod Photoreceptor Outer Segment Sperm Head Plasma Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity	G Protein-coupled Receptor Activity 11-cis Retinal Binding Protein Binding G Protein-coupled Photoreceptor Activity Photoreceptor Activity Metal Ion Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Viral Genome Replication Receptor Internalization Positive Regulation Of Catecholamine Secretion Negative Regulation Of Striated Muscle Contraction Symbiont Entry Into Host Cell Cardiac Muscle Contraction Negative Regulation Of Relaxation Of Smooth Muscle	Microtubule Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Phototransduction, Visible Light Response To Light Stimulus Detection Of Light Stimulus Response To Light Intensity Gene Expression Absorption Of Visible Light G Protein-coupled Opsin Signaling Pathway Thermotaxis Photoreceptor Cell Maintenance Sensory Perception Of Light Stimulus Detection Of Temperature Stimulus Involved In Thermoception Retina Development In Camera-type Eye Cellular Response To Light Stimulus Podosome Assembly Rod Bipolar Cell Differentiation
Pathways		Calmodulin induced events G alpha (q) signalling events G alpha (s) signalling events Activation of SMO Activation of SMO Cargo recognition for clathrin-mediated endocytosis	The canonical retinoid cycle in rods (twilight vision) Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G alpha (i) signalling events Opsins VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs		ATP	Halothane N-Acetylmethionine 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine B-nonylglucoside Phosphonothreonine B-2-Octylglucoside Hexadecanal Palmitic Acid Heptane-1,2,3-Triol Dodecyldimethylamine N-oxide (Hydroxyethyloxy)Tri(Ethyloxy)Octane e Dexfosfoserine
Diseases			Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP) Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS			Diisocyanate-induced asthma ( 25918132) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		49 interacting genes: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 ERBB2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB3 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PLCB1 PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2	12 interacting genes: ARR3 ARRB2 CD79A DERL1 GNGT1 GRK1 GRK2 GRK5 GRK6 PPP2CA PRKCA SAG
Entrez ID		156	6010
HPRD ID		00182	01584
Ensembl ID		ENSG00000173020	ENSG00000163914
Uniprot IDs		A0A0S2Z392 P25098	P08100
PDB IDs		1BAK 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1 5UKK 5UKL 5UUU 5UVC 5WG3 5WG4 5WG5 6C2Y 6U7C 7K7L 7K7Z 7PWD	4ZWJ 5DGY 5W0P 6CMO
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction Regulation Of MAPK Cascade Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Plasma Membrane Regulation Of Biological Quality Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling System Process Positive Regulation Of Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Modulation Of Chemical Synaptic Transmission Enzyme Binding Intracellular Signal Transduction G Protein-coupled Receptor Activity Regulation Of Transport Epidermal Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Vesicle-mediated Transport Response To Lipid Cell Surface Receptor Signaling Pathway ERBB2 Signaling Pathway Nervous System Process Response To Hormone Response To Growth Factor Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Locomotion Positive Regulation Of Protein Localization Regulation Of System Process Positive Regulation Of Cell Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Metal Ion Transport Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Protein Kinase C Signaling Negative Regulation Of Catabolic Process Cellular Response To Oxygen-containing Compound Regulation Of ERK1 And ERK2 Cascade Regulation Of Proteolysis	G Protein-coupled Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity Signal Transduction G Protein-coupled Receptor Internalization Photoreceptor Outer Segment Receptor Internalization G Protein-coupled Receptor Binding Opsin Binding Phototransduction Protein Serine/threonine Kinase Activity Receptor-mediated Endocytosis G Protein-coupled Opsin Signaling Pathway G Protein-coupled Receptor Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Photoreceptor Inner Segment Detection Of Light Stimulus Negative Adaptation Of Signaling Pathway Tachykinin Receptor Signaling Pathway Protein Kinase Activity Kinase Activity Detection Of Abiotic Stimulus Photoreceptor Disc Membrane Endocytosis Nervous System Process System Process Sensory Perception Membrane Phosphoprotein Binding Positive Regulation Of Cardiac Muscle Hypertrophy Postsynaptic Signal Transduction Negative Regulation Of Relaxation Of Smooth Muscle Import Into Cell Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Muscle System Process Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Detection Of Stimulus RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Edg-2 Lysophosphatidic Acid Receptor Binding Angiotensin Receptor Binding Response To Light Stimulus RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Derlin-1-VIMP Complex Protein Phosphorylation
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