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GRK2 and PIK3CG
Number of citations of the paper that reports this interaction (PubMedID
12163475
)
35
Data Source:
HPRD
(in vivo)
GRK2
PIK3CG
Description
G protein-coupled receptor kinase 2
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Cilium
Membrane
Cytoplasmic Side Of Mitochondrial Outer Membrane
Cell Projection
Synapse
Presynapse
Postsynapse
Cytoplasm
Cytosol
Plasma Membrane
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Complex, Class IA
Phosphatidylinositol 3-kinase Complex, Class IB
Membrane
Molecular Function
Nucleotide Binding
G Protein-coupled Receptor Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
G Protein-coupled Receptor Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Alpha-2A Adrenergic Receptor Binding
Edg-2 Lysophosphatidic Acid Receptor Binding
Beta-adrenergic Receptor Kinase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
1-phosphatidylinositol-3-kinase Activity
Transferase Activity
1-phosphatidylinositol-4-phosphate 3-kinase Activity
Identical Protein Binding
Ephrin Receptor Binding
1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
Protein Serine Kinase Activity
Biological Process
Regulation Of The Force Of Heart Contraction
Desensitization Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of The Force Of Heart Contraction By Chemical Signal
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Tachykinin Receptor Signaling Pathway
Heart Development
Viral Genome Replication
Receptor Internalization
Positive Regulation Of Catecholamine Secretion
Negative Regulation Of Striated Muscle Contraction
Symbiont Entry Into Host Cell
Cardiac Muscle Contraction
Negative Regulation Of Relaxation Of Smooth Muscle
Angiogenesis
Positive Regulation Of Cytokine Production
Adaptive Immune Response
Immune System Process
Dendritic Cell Chemotaxis
Positive Regulation Of Acute Inflammatory Response
Respiratory Burst Involved In Defense Response
Sphingosine-1-phosphate Receptor Signaling Pathway
Lipid Metabolic Process
Endocytosis
Chemotaxis
Inflammatory Response
Immune Response
G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Positive Regulation Of Endothelial Cell Migration
T Cell Chemotaxis
Negative Regulation Of Triglyceride Catabolic Process
Cell Migration
Neutrophil Chemotaxis
Secretory Granule Localization
Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Rac Protein Signal Transduction
Natural Killer Cell Chemotaxis
Phosphatidylinositol-3-phosphate Biosynthetic Process
T Cell Proliferation
T Cell Activation
Mast Cell Degranulation
Positive Regulation Of MAP Kinase Activity
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Innate Immune Response
Regulation Of Angiogenesis
Phosphatidylinositol Phosphate Biosynthetic Process
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Cardiac Muscle Contraction
Platelet Aggregation
Cellular Response To CAMP
Neutrophil Extravasation
Hepatocyte Apoptotic Process
Regulation Of Calcium Ion Transmembrane Transport
Negative Regulation Of Fibroblast Apoptotic Process
Pathways
Calmodulin induced events
G alpha (q) signalling events
G alpha (s) signalling events
Activation of SMO
Activation of SMO
Cargo recognition for clathrin-mediated endocytosis
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Synthesis of PIPs at the plasma membrane
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Co-stimulation by ICOS
Drugs
ATP
Staurosporine
Myricetin
LY-294002
Quercetin
5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE
XL765
TG100-115
2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE
N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamide
5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one
3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL
(5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE
Wortmannin
1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Duvelisib
Fostamatinib
Diseases
GWAS
Antisaccade task score (
31596458
)
Blood pressure (
21909110
)
Carotid intima media thickness (
21909108
30510157
)
Carotid plaque (
30510157
)
Mean platelet volume (
22423221
19820697
22139419
28031487
24026423
)
Metabolite levels (
23823483
)
Platelet aggregation (
29185836
)
Platelet count (
22139419
22423221
29066854
29403010
)
Pulse pressure (
29403010
30487518
26390057
28739976
27841878
)
Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) (
29912962
)
Pulse pressure x alcohol consumption interaction (2df test) (
29912962
)
Systolic blood pressure (
28739976
27841878
)
Systolic blood pressure (cigarette smoking interaction) (
29455858
)
Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) (
29912962
)
Systolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Interacting Genes
49 interacting genes:
ADRA2A
ADRB2
AGTR1
AKAP12
ARRB1
BDKRB2
CAPN2
CAV1
CCR4
CCR5
CSNK2B
EGF
EGFR
EPHA2
ERBB2
FBXO25
FPR1
FSHR
GIT1
GIT2
GNA15
GNAQ
GNB3
GRM1
HDAC6
KCNIP3
MAPK3
MC4R
MDM2
NCS1
OPRD1
PDC
PDCL
PDE6G
PEBP1
PIK3CG
PLCB1
PRKACA
PRKCA
PRKCB
PRKCD
PRKCG
RASGRF1
RCVRN
RHO
RPLP2
SNCA
SRC
TPM2
22 interacting genes:
CD28
EPHA8
GAB1
GRB2
GRK2
GSN
HRAS
IL6ST
KIT
KRAS
LYN
NOTCH1
NRAS
PIK3CD
PIK3R5
PIK3R6
PTPN11
SEC14L2
SET
SMPD2
TPM2
ZNF282
Entrez ID
156
5294
HPRD ID
00182
03135
Ensembl ID
ENSG00000173020
ENSG00000105851
Uniprot IDs
A0A0S2Z392
P25098
A8K9G9
P48736
PDB IDs
1BAK
3CIK
3KRW
3KRX
3V5W
4MK0
4PNK
5HE1
5UKK
5UKL
5UUU
5UVC
5WG3
5WG4
5WG5
6C2Y
6U7C
7K7L
7K7Z
7PWD
1E8Y
1E8Z
1HE8
2A4Z
2A5U
2CHW
2CHX
2CHZ
2V4L
3APC
3APD
3APF
3CSF
3CST
3DBS
3DPD
3ENE
3IBE
3L08
3L13
3L16
3L17
3L54
3LJ3
3MJW
3ML8
3ML9
3NZS
3NZU
3OAW
3P2B
3PRE
3PRZ
3PS6
3QAQ
3QAR
3QJZ
3QK0
3R7Q
3R7R
3S2A
3SD5
3T8M
3TJP
3TL5
3ZVV
3ZW3
4ANU
4ANV
4ANW
4ANX
4AOF
4DK5
4EZJ
4EZK
4EZL
4F1S
4FA6
4FAD
4FHJ
4FHK
4FJY
4FJZ
4FLH
4FUL
4G11
4GB9
4HLE
4HVB
4J6I
4KZ0
4KZC
4PS3
4PS7
4PS8
4URK
4WWN
4WWO
4WWP
4XX5
4XZ4
5EDS
5G2N
5G55
5JHA
5JHB
5KAE
5OQ4
5T23
6AUD
6C1S
6FH5
6GQ7
6T3B
6T3C
6XRL
6XRM
6XRN
7JWE
7JWZ
7JX0
7KKE
7MEZ
7Z61
8DP0
8SC8
9GG9
Enriched GO Terms of Interacting Partners
?
G Protein-coupled Receptor Signaling Pathway
Regulation Of Cell Communication
Signal Transduction
Regulation Of Signaling
Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Plasma Membrane
Regulation Of Biological Quality
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
System Process
Positive Regulation Of Signal Transduction
Regulation Of G Protein-coupled Receptor Signaling Pathway
Regulation Of Multicellular Organismal Process
Modulation Of Chemical Synaptic Transmission
Enzyme Binding
Intracellular Signal Transduction
G Protein-coupled Receptor Activity
Regulation Of Transport
Epidermal Growth Factor Receptor Signaling Pathway
Intracellular Signaling Cassette
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Vesicle-mediated Transport
Response To Lipid
Cell Surface Receptor Signaling Pathway
ERBB2 Signaling Pathway
Nervous System Process
Response To Hormone
Response To Growth Factor
Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity
Regulation Of Locomotion
Positive Regulation Of Protein Localization
Regulation Of System Process
Positive Regulation Of Cell Migration
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Metal Ion Transport
Regulation Of Phosphorus Metabolic Process
Regulation Of Cellular Component Organization
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Protein Kinase C Signaling
Negative Regulation Of Catabolic Process
Cellular Response To Oxygen-containing Compound
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Proteolysis
T Cell Costimulation
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of MAPK Cascade
Regulation Of MAPK Cascade
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Signal Transduction
Phosphatidylinositol 3-kinase Complex
Regulation Of Cell-cell Adhesion
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Cell-cell Adhesion
Phosphatidylinositol 3-kinase Complex, Class IA
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Signal Transduction
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Cell Communication
Regulation Of Cell Adhesion
Regulation Of T Cell Activation
Intracellular Signal Transduction
Positive Regulation Of Signaling
Positive Regulation Of Cell Activation
Positive Regulation Of Cell Population Proliferation
Regulation Of Immune Response
Antigen Receptor-mediated Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Glial Cell Development
Positive Regulation Of Gliogenesis
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Adhesion
Regulation Of Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Lymphocyte Activation
Ras Protein Signal Transduction
Regulation Of Multicellular Organismal Development
Response To Mechanical Stimulus
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Programmed Cell Death
Immune System Process
Plasma Membrane
Cell Development
Immune Response
Regulation Of Gliogenesis
Positive Regulation Of Gene Expression
Positive Regulation Of Neurogenesis
Regulated Exocytosis
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Tagcloud (Intersection)
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