GRK2 and EPHA2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GRK2	EPHA2
Description		G protein-coupled receptor kinase 2	EPH receptor A2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cilium Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Cell Projection Synapse Presynapse Postsynapse	Plasma Membrane Focal Adhesion Cell Surface Membrane Lamellipodium Leading Edge Membrane Lamellipodium Membrane Ruffle Membrane Cell Projection Receptor Complex Tight Junction Anchoring Junction
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity	Nucleotide Binding Virus Receptor Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Cadherin Binding Molecular Function Activator Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Viral Genome Replication Receptor Internalization Positive Regulation Of Catecholamine Secretion Negative Regulation Of Striated Muscle Contraction Symbiont Entry Into Host Cell Cardiac Muscle Contraction Negative Regulation Of Relaxation Of Smooth Muscle	Skeletal System Development Angiogenesis Blood Vessel Development Vasculogenesis Osteoblast Differentiation Negative Regulation Of Cytokine Production Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Apoptotic Process Response To Stress Inflammatory Response Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Lamellipodium Assembly Notochord Formation Cell Migration Negative Regulation Of Angiogenesis Neural Tube Development Central Nervous System Neuron Differentiation Cell Differentiation Regulation Of Cell Adhesion Keratinocyte Differentiation Osteoclast Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Epithelial Cell Differentiation Negative Regulation Of Chemokine Production Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Adhesion Mediated By Integrin Post-anal Tail Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis CAMP Metabolic Process Symbiont Entry Into Host Cell Bone Remodeling Ephrin Receptor Signaling Pathway Axial Mesoderm Formation Animal Organ Development Blood Vessel Morphogenesis Notochord Morphogenesis Cell Motility Defense Response To Gram-positive Bacterium Notochord Cell Development Cell Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Lens Fiber Cell Morphogenesis Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Protein Localization To Plasma Membrane Activation Of GTPase Activity Negative Regulation Of Lymphangiogenesis Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Bicellular Tight Junction Assembly Pericyte Cell Differentiation
Pathways		Calmodulin induced events G alpha (q) signalling events G alpha (s) signalling events Activation of SMO Activation of SMO Cargo recognition for clathrin-mediated endocytosis	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs		ATP	Dasatinib Phosphoaminophosphonic Acid-Adenylate Ester Regorafenib Fostamatinib
Diseases
GWAS			Alanine aminotransferase levels ( 33339817 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Blood protein levels ( 30072576) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
Interacting Genes		49 interacting genes: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 ERBB2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB3 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PLCB1 PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2	81 interacting genes: ABCB5 ACP1 AKT1 ANXA1 ARAF ARNT AURKA BECN1 CBL CBLC CCND2 CD44 CDC42 CDH5 CDK17 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CLDN4 DUSP14 DUSP18 DUSP19 DUSP26 DUSP29 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EGFR FZR1 GATAD1 GLIS2 GRB2 GRK2 GRM1 HGF HIF1A ILKAP KDELR2 KPNA3 LATS2 LSM7 MAP2K5 MAP2K6 MAPK14 MDM4 MET MSH2 MYC NF1 NF2 NFIC NUDT9 PIK3R1 PIK3R2 PPM1L PSME2 PTEN PTK2 PTPN11 PTPN7 PTPRR RASA1 RASSF1 RBL1 RELA RNF5 SHC1 SLA STK11 STYX TEAD2 TIAM1 TNFAIP1 TP53 TPTE TPTE2 UBE4A
Entrez ID		156	1969
HPRD ID		00182	01494
Ensembl ID		ENSG00000173020	ENSG00000142627
Uniprot IDs		A0A0S2Z392 P25098	P29317
PDB IDs		1BAK 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1 5UKK 5UKL 5UUU 5UVC 5WG3 5WG4 5WG5 6C2Y 6U7C 7K7L 7K7Z 7PWD	1MQB 2E8N 2K9Y 2KSO 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0 3SKJ 4P2K 4PDO 4TRL 5EK7 5I9U 5I9V 5I9W 5I9X 5I9Y 5I9Z 5IA0 5IA1 5IA2 5IA3 5IA4 5IA5 5NJZ 5NK0 5NK1 5NK2 5NK3 5NK4 5NK5 5NK6 5NK7 5NK8 5NK9 5NKA 5NKB 5NKC 5NKD 5NKE 5NKF 5NKG 5NKH 5NKI 5NZ9 6B9L 6F7M 6F7N 6FNF 6FNG 6FNH 6HES 6HET 6HEU 6HEV 6HEW 6HEX 6HEY 6NJZ 6NK0 6NK1 6NK2 6NKP 6Q7B 6Q7C 6Q7D 6Q7E 6Q7F 6Q7G 6RW2 7B7N 7CZE 7CZF 7KJA 7KJB 7KJC 8BIN 8BIO 8BK0 8BM8 8BOC 8BOD 8BOF 8BOG 8BOH 8BOI 8BOK 8BOM 8QQY 8T9B 8TRS 8TRT 8TRV 8TV1 8TV5 8XPV
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction Regulation Of MAPK Cascade Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Plasma Membrane Regulation Of Biological Quality Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling System Process Positive Regulation Of Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Modulation Of Chemical Synaptic Transmission Enzyme Binding Intracellular Signal Transduction G Protein-coupled Receptor Activity Regulation Of Transport Epidermal Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Vesicle-mediated Transport Response To Lipid Cell Surface Receptor Signaling Pathway ERBB2 Signaling Pathway Nervous System Process Response To Hormone Response To Growth Factor Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Locomotion Positive Regulation Of Protein Localization Regulation Of System Process Positive Regulation Of Cell Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Metal Ion Transport Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Protein Kinase C Signaling Negative Regulation Of Catabolic Process Cellular Response To Oxygen-containing Compound Regulation Of ERK1 And ERK2 Cascade Regulation Of Proteolysis	Regulation Of Intracellular Signal Transduction Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Cell Communication Regulation Of Signaling Protein Tyrosine Phosphatase Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Cycle Process Intracellular Signal Transduction Phosphoprotein Phosphatase Activity Negative Regulation Of Programmed Cell Death Ephrin Receptor Binding Phosphotyrosine Residue Binding Negative Regulation Of Apoptotic Process Cell Differentiation Ephrin Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Regulation Of Programmed Cell Death Regulation Of MAPK Cascade Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Apoptotic Process Intracellular Signaling Cassette Regulation Of Cell Population Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Adhesion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cellular Developmental Process Response To Growth Factor Protein Dephosphorylation Negative Regulation Of Intracellular Signal Transduction Protein Kinase Binding Positive Regulation Of Signal Transduction Animal Organ Development MAPK Cascade Developmental Process Cellular Response To Stress Positive Regulation Of Intracellular Signal Transduction Response To Radiation Response To UV Regulation Of Protein Localization To Nucleus Neurotrophin TRKA Receptor Binding Negative Regulation Of MAPK Cascade Positive Regulation Of Cell Communication
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