GRK2 and CCR5

Number of citations of the paper that reports this interaction (PubMedID 10085131)
0

Data Source:
HPRD (in vivo)

		GRK2	CCR5
Description		G protein-coupled receptor kinase 2	C-C motif chemokine receptor 5
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cilium Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Cell Projection Synapse Presynapse Postsynapse	Cytoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity	Virus Receptor Activity Actin Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Identical Protein Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Viral Genome Replication Receptor Internalization Positive Regulation Of Catecholamine Secretion Negative Regulation Of Striated Muscle Contraction Symbiont Entry Into Host Cell Cardiac Muscle Contraction Negative Regulation Of Relaxation Of Smooth Muscle	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Apoptotic Process Chemotaxis Defense Response Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Signaling Symbiont Entry Into Host Cell Cell Chemotaxis Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Negative Regulation Of Macrophage Apoptotic Process
Pathways		Calmodulin induced events G alpha (q) signalling events G alpha (s) signalling events Activation of SMO Activation of SMO Cargo recognition for clathrin-mediated endocytosis	Binding and entry of HIV virion Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs		ATP	Maraviroc AMD-070 CCR5 mAb Leronlimab Aplaviroc Vicriviroc Ibalizumab INCB-9471
Diseases
GWAS			Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 20190752) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Type 1 diabetes ( 25751624) Ulcerative colitis ( 26192919 28067908)
Interacting Genes		49 interacting genes: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 ERBB2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB3 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PLCB1 PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2	43 interacting genes: AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 EMP1 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GRK2 GRK3 IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B SLC20A2 STAT1 STAT3 STAT5A TXK
Entrez ID		156	1234
HPRD ID		00182	03223
Ensembl ID		ENSG00000173020	ENSG00000160791
Uniprot IDs		A0A0S2Z392 P25098	P51681 Q38L21
PDB IDs		1BAK 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1 5UKK 5UKL 5UUU 5UVC 5WG3 5WG4 5WG5 6C2Y 6U7C 7K7L 7K7Z 7PWD	2L87 2MZX 2RLL 2RRS 4MBS 5UIW 5YD3 5YD4 5YD5 5YY4 6FGP 6MEO 6MET 7F1Q 7F1R 7F1S 7NJZ 7NW3 7O7F 8AS2 8AS3
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction Regulation Of MAPK Cascade Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Plasma Membrane Regulation Of Biological Quality Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling System Process Positive Regulation Of Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Modulation Of Chemical Synaptic Transmission Enzyme Binding Intracellular Signal Transduction G Protein-coupled Receptor Activity Regulation Of Transport Epidermal Growth Factor Receptor Signaling Pathway Intracellular Signaling Cassette Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Vesicle-mediated Transport Response To Lipid Cell Surface Receptor Signaling Pathway ERBB2 Signaling Pathway Nervous System Process Response To Hormone Response To Growth Factor Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Locomotion Positive Regulation Of Protein Localization Regulation Of System Process Positive Regulation Of Cell Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Metal Ion Transport Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Protein Kinase C Signaling Negative Regulation Of Catabolic Process Cellular Response To Oxygen-containing Compound Regulation Of ERK1 And ERK2 Cascade Regulation Of Proteolysis	Chemokine-mediated Signaling Pathway CCR Chemokine Receptor Binding Cytokine-mediated Signaling Pathway Chemokine Activity G Protein-coupled Receptor Signaling Pathway Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Antimicrobial Humoral Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Cytokine Activity CCR5 Chemokine Receptor Binding Immune System Process Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Cell Migration Humoral Immune Response Regulation Of Cell Motility Signal Transduction Regulation Of Locomotion Granulocyte Chemotaxis Leukocyte Migration Chemotaxis Granulocyte Migration Defense Response Cell Migration Leukocyte Chemotaxis Inflammatory Response Locomotion Response To Other Organism Response To External Biotic Stimulus Cell Motility Regulation Of Lymphocyte Chemotaxis Myeloid Leukocyte Migration Defense Response To Symbiont Positive Regulation Of Natural Killer Cell Chemotaxis Defense Response To Other Organism Guanyl Nucleotide Binding CCR1 Chemokine Receptor Binding G Protein-coupled Receptor Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Chemotaxis Cell Surface Receptor Signaling Pathway Via STAT Non-membrane Spanning Protein Tyrosine Kinase Activity G-protein Beta/gamma-subunit Complex Binding Protein Kinase Activity Interleukin-9-mediated Signaling Pathway
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