FBXO25 and MAT2B

Number of citations of the paper that reports this interaction (PMID 23940030)
0

Data Source:
BioGRID (enzymatic study)

		FBXO25	MAT2B
Gene Name		F-box protein 25	methionine adenosyltransferase II, beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex	Intracellular Nucleus Mitochondrion Cytosol Methionine Adenosyltransferase Complex Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	Enzyme Binding Methionine Adenosyltransferase Regulator Activity
	Biological Process	Protein Ubiquitination	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Xenobiotic Metabolic Process Methylation Small Molecule Metabolic Process Regulation Of Catalytic Activity
Pathways			Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS			Aging ( 22773346) Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		80 interactors: ADRBK1 ANKRD13A APLF AXL BMX C11orf63 C19orf57 C6orf106 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ING3 IRS1 KDR KRT8 LMCD1 LUC7L MAT2B NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	6 interactors: APP FBXO25 KPNA3 KPNA4 MAT2A TRIM27
Entrez ID		26260	27430
HPRD ID		16439	05701
Ensembl ID		ENSG00000147364	ENSG00000038274
Uniprot IDs		Q8TCJ0	Q9NZL9
PDB IDs			2YDX 2YDY
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Peptidyl-amino Acid Modification Cellular Metabolic Process Cellular Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Neurotrophin Signaling Pathway Viral Process Protein Phosphorylation Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Response To Growth Factor Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Gene Expression Peptidyl-tyrosine Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Phospholipase C Activity Phosphorylation Intracellular Signal Transduction Regulation Of Cellular Process Rhythmic Process Protein Autophosphorylation Positive Regulation Of Phospholipase Activity Response To Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance Immune Response Proteasomal Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Response To UV-A Peptidyl-serine Autophosphorylation Regulation Of Phospholipase Activity Apoptotic Process Positive Regulation Of Lipase Activity Defense Response Protein Metabolic Process Regulation Of Cell Death Immune System Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process	NLS-bearing Protein Import Into Nucleus Intracellular Transport Protein Import Into Nucleus Nuclear Import Negative Regulation Of Interleukin-2 Secretion Synaptic Growth At Neuromuscular Junction Viral Penetration Into Host Nucleus Protein Import Establishment Of Localization In Cell Collateral Sprouting In Absence Of Injury Protein Localization To Nucleus Collateral Sprouting Axon Midline Choice Point Recognition Cellular Localization S-adenosylmethionine Biosynthetic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Calcium Ion Import Axon Choice Point Recognition Nucleocytoplasmic Transport Nuclear Transport Interferon-gamma Secretion Neuron Remodeling Establishment Of Protein Localization To Organelle
Tagcloud ?			adenosyltransferase arfgap coimmunoprecipitation erk erk2 gateway git1 hepatology interacting interplay knocked mek mek1 methionine observe opposite orthotopic partner promoted proteomics pull raised recruits scaffold translated v1 v2 verified
Tagcloud (Difference) ?			adenosyltransferase arfgap coimmunoprecipitation erk erk2 gateway git1 hepatology interacting interplay knocked mek mek1 methionine observe opposite orthotopic partner promoted proteomics pull raised recruits scaffold translated v1 v2 verified
Tagcloud (Intersection) ?