FBXO25 and PCK1

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		FBXO25	PCK1
Description		F-box protein 25	phosphoenolpyruvate carboxykinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	Nucleotide Binding Magnesium Ion Binding Phosphoenolpyruvate Carboxykinase Activity Phosphoenolpyruvate Carboxykinase (GTP) Activity GTP Binding Kinase Activity Transferase Activity Lyase Activity Carboxy-lyase Activity Purine Nucleotide Binding Manganese Ion Binding Carboxylic Acid Binding Metal Ion Binding Protein Serine Kinase Activity (using GTP As Donor)
	Biological Process	Protein Ubiquitination	Glucose Metabolic Process Gluconeogenesis Oxaloacetate Metabolic Process NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Response To Bacterium Peptidyl-serine Phosphorylation Propionate Catabolic Process Response To Insulin Cellular Response To Insulin Stimulus SREBP-SCAP Complex Retention In Endoplasmic Reticulum Glucose Homeostasis Response To Starvation Positive Regulation Of Memory T Cell Differentiation Dicarboxylic Acid Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Glyceraldehyde-3-phosphate Biosynthetic Process Glycerol Biosynthetic Process From Pyruvate Positive Regulation Of Lipid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Cellular Response To Potassium Ion Starvation Protein Maturation Hepatocyte Differentiation Cellular Response To Glucose Stimulus Cellular Response To Dexamethasone Stimulus Tricarboxylic Acid Metabolic Process
Pathways			Abacavir metabolism Transcriptional regulation of white adipocyte differentiation Gluconeogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs			Phosphoenolpyruvate 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 5'-Guanylylmethylenebisphosphonate
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)	Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 31451708) Hematocrit ( 32888494) Hemoglobin ( 32888494) Prudent dietary pattern ( 28644415) Red blood cell count ( 32888494) Response to fenofibrate (adiponectin levels) ( 23149075) Serum alkaline phosphatase levels ( 31666285) Triglycerides ( 30275531) Type 2 diabetes ( 23300278)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	8 interacting genes: AKT1 APP C1R FBXO25 IKBKG INSIG1 INSIG2 UBR5
Entrez ID		26260	5105
HPRD ID		16439	02028
Ensembl ID		ENSG00000147364	ENSG00000124253
Uniprot IDs		Q8TCJ0	P35558
PDB IDs			1KHB 1KHE 1KHF 1KHG 1M51 1NHX 2GMV
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly	SREBP-SCAP Complex Retention In Endoplasmic Reticulum Negative Regulation Of SREBP Signaling Pathway Regulation Of SREBP Signaling Pathway Maintenance Of Protein Localization In Endoplasmic Reticulum Positive Regulation Of Cholesterol Biosynthetic Process NLS-bearing Protein Import Into Nucleus Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process ER-nucleus Signaling Pathway Positive Regulation Of Steroid Biosynthetic Process SREBP-SCAP-Insig Complex Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Steroid Metabolic Process Maintenance Of Protein Localization In Organelle Regulation Of Cholesterol Metabolic Process Maintenance Of Protein Location In Cell Regulation Of Cellular Response To Stress Maintenance Of Protein Location Nuclear Transport Nucleocytoplasmic Transport Maintenance Of Location In Cell Cranial Suture Morphogenesis Maintenance Of Location Regulation Of Steroid Biosynthetic Process SREBP Signaling Pathway Cellular Response To Sterol Depletion Regulation Of Response To Endoplasmic Reticulum Stress Protein Maturation Response To Sterol Depletion Anoikis Regulation Of Small Molecule Metabolic Process Cellular Response To Insulin Stimulus Protein K29-linked Ubiquitination Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Small Molecule Metabolic Process Oxysterol Binding Protein Import Into Nucleus Negative Regulation Of Signaling Negative Regulation Of Cell Communication Import Into Nucleus Establishment Of Localization In Cell Craniofacial Suture Morphogenesis Regulation Of Ketone Metabolic Process Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process
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