FBXO25 and PADI4

Number of citations of the paper that reports this interaction (PMID 23940030)
0

Data Source:
BioGRID (enzymatic study)

		FBXO25	PADI4
Gene Name		F-box protein 25	peptidyl arginine deiminase, type IV
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex	Nucleus Cytoplasm
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Arginine Deiminase Activity
	Biological Process	Protein Ubiquitination	Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Chromatin Modification Protein Citrullination Stem Cell Maintenance Histone H3-R26 Citrullination Histone Citrullination Innate Immune Response
Pathways
Drugs			L-Citrulline N-[(1S)-1-(AMINOCARBONYL)-4-(ETHANIMIDOYLAMINO)BUTYL]BENZAMIDE
Diseases
GWAS			Basal cell carcinoma ( 18849993) Rheumatoid arthritis ( 21452313 21505073)
Protein-Protein Interactions		80 interactors: ADRBK1 ANKRD13A APLF AXL BMX C11orf63 C19orf57 C6orf106 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ING3 IRS1 KDR KRT8 LMCD1 LUC7L MAT2B NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	6 interactors: ANXA4 APP FBXO25 HDAC2 HIST2H3A NPM1
Entrez ID		26260	23569
HPRD ID		16439	05635
Ensembl ID		ENSG00000147364	ENSG00000159339
Uniprot IDs		Q8TCJ0	B2RBW0 Q9UM07
PDB IDs			1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Peptidyl-amino Acid Modification Cellular Metabolic Process Cellular Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Neurotrophin Signaling Pathway Viral Process Protein Phosphorylation Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Response To Growth Factor Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Gene Expression Peptidyl-tyrosine Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Phospholipase C Activity Phosphorylation Intracellular Signal Transduction Regulation Of Cellular Process Rhythmic Process Protein Autophosphorylation Positive Regulation Of Phospholipase Activity Response To Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Organic Substance Immune Response Proteasomal Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Response To UV-A Peptidyl-serine Autophosphorylation Regulation Of Phospholipase Activity Apoptotic Process Positive Regulation Of Lipase Activity Defense Response Protein Metabolic Process Regulation Of Cell Death Immune System Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process	Chromatin Silencing Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Blood Coagulation Hemostasis ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Body Fluid Levels Gene Silencing Wound Healing Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Wounding Dendrite Development Synaptic Growth At Neuromuscular Junction Negative Regulation Of Catalytic Activity Collateral Sprouting In Absence Of Injury Maintenance Of Chromatin Silencing Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Cellular Metabolic Process Chromatin Remodeling Negative Regulation Of Neuron Differentiation Negative Regulation Of Interleukin-8 Secretion Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Programmed Cell Death Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Gene Expression, Epigenetic Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of RNA Metabolic Process Negative Regulation Of Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Negative Regulation Of MHC Class II Biosynthetic Process Axon Choice Point Recognition Fungiform Papilla Formation Negative Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Translation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Positive Regulation Of Proteolysis Fungiform Papilla Morphogenesis
Tagcloud ?			arginine barr carm1 centre compelling continuing deiminase dissect ebv epstein gc germinal hl hodgkin latent lmp1 lymphomagenesis methyltransferases modulated next precursors presumptive prmt prmt1 prmt5 reed stably sternberg transforming
Tagcloud (Difference) ?			arginine barr carm1 centre compelling continuing deiminase dissect ebv epstein gc germinal hl hodgkin latent lmp1 lymphomagenesis methyltransferases modulated next precursors presumptive prmt prmt1 prmt5 reed stably sternberg transforming
Tagcloud (Intersection) ?