ADRBK1 and GRM1

Number of citations of the paper that reports this interaction (PMID 15870073)
9

Data Source:
HPRD (in vivo, in vitro)

		ADRBK1	GRM1
Gene Name		adrenergic, beta, receptor kinase 1	glutamate receptor, metabotropic 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Primary Cilium	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Dendrite G-protein Coupled Receptor Dimeric Complex G-protein Coupled Receptor Homodimeric Complex
	Molecular Function	Protein Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Binding ATP Binding Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity	G-protein Coupled Receptor Activity Protein Binding Glutamate Receptor Activity
	Biological Process	Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Fibroblast Growth Factor Receptor Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Receptor Internalization Positive Regulation Of Catecholamine Secretion Termination Of G-protein Coupled Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Striated Muscle Contraction Neurotrophin TRK Receptor Signaling Pathway Cardiac Muscle Contraction	Activation Of MAPKK Activity Activation Of MAPK Activity G-protein Coupled Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Synaptic Transmission Locomotory Behavior Sensory Perception Of Pain Dimeric G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Regulation Of Sensory Perception Of Pain Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To Electrical Stimulus
Pathways		G alpha (q) signalling events Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Hedgehog 'on' state Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Calmodulin induced events Signalling by NGF DAP12 interactions PLC beta mediated events Opioid Signalling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Calmodulin induced events Downstream signal transduction PLC-gamma1 signalling Signaling by Hedgehog Signaling by EGFR in Cancer Activation of SMO	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Adenosine triphosphate	L-Glutamic Acid Acamprosate 4-(1-Amino-1-Carboxy-Ethyl)-Benzoic Acid
Diseases
GWAS
Protein-Protein Interactions		47 interactors: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB1 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2	12 interactors: ADORA1 ADRBK1 EFNB2 GAPDH GPRASP1 GRASP HOMER1 HOMER2 ITPR1 OPTN PRKCA TUBB
Entrez ID		156	2911
HPRD ID		00182	05129
Ensembl ID		ENSG00000173020	ENSG00000152822
Uniprot IDs		P25098	F8W805 Q13255 Q59HC2
PDB IDs		1BAK 3CIK 3KRW 3KRX 3V5W	3KS9
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Cell Communication Signaling Platelet Activation Signal Transduction Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To External Stimulus Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Regulation Of Signaling Positive Regulation Of Metabolic Process Blood Coagulation Hemostasis Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Cell Activation Regulation Of Body Fluid Levels Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Wound Healing Cellular Calcium Ion Homeostasis Regulation Of Metabolic Process Calcium Ion Homeostasis Positive Regulation Of Cellular Metabolic Process Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cytosolic Calcium Ion Homeostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase Activity Response To Wounding	Defense Response Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Negative Regulation Of Striated Muscle Contraction Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Negative Regulation Of Signaling Positive Regulation Of Lipase Activity Regulation Of Signal Transduction Chemical Homeostasis Within A Tissue Behavioral Response To Cocaine Regulation Of Signaling Innate Immune Response Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Regulation Of Muscle Contraction Negative Regulation Of Heart Contraction Epidermal Growth Factor Receptor Signaling Pathway Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Heart Contraction Cell Death Regulation Of Behavior Cellular Response To Stimulus Death Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of The Force Of Heart Contraction Negative Regulation Of Signal Transduction Signal Transduction Neurotrophin TRK Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Neurotrophin Signaling Pathway Multicellular Organismal Homeostasis Regulation Of Secretion Musculoskeletal Movement Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-threonine Phosphorylation Immune Response Muscle System Process Regulation Of Hormone Secretion Response To Cocaine Cell Surface Receptor Signaling Pathway Cell Communication Homeostatic Process Glutamate Receptor Signaling Pathway
Tagcloud ?		adrenergic adverse antihypertensive atenolol bp diastolic gln41leu grk2 grk5 grks hydrochlorothiazide hypertensives infarction leu41 leukocyte lymphoblastoid mmhg pharmacogenomic protects rs1894111 sequenced snp snps sr substudy systolic trandolapril verapamil whites	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi
Tagcloud (Difference) ?		adrenergic adverse antihypertensive atenolol bp diastolic gln41leu grk2 grk5 grks hydrochlorothiazide hypertensives infarction leu41 leukocyte lymphoblastoid mmhg pharmacogenomic protects rs1894111 sequenced snp snps sr substudy systolic trandolapril verapamil whites	asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shbg shr symbol wtc zi
Tagcloud (Intersection) ?