FBXO25 and APLF

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		FBXO25	APLF
Description		F-box protein 25	aprataxin and PNKP like factor
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Site Of Double-strand Break Site Of DNA Damage
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity DNA Endonuclease Activity Protein Binding Zinc Ion Binding 3'-5' Exonuclease Activity Hydrolase Activity Histone Binding Protein Folding Chaperone Metal Ion Binding Poly-ADP-D-ribose Binding Histone Chaperone Activity ADP-D-ribose Modification-dependent Protein Binding
	Biological Process	Protein Ubiquitination	Single Strand Break Repair DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Protein Folding DNA Damage Response Embryo Implantation Regulation Of Epithelial To Mesenchymal Transition Regulation Of Isotype Switching Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling
Pathways
Drugs
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)	Restless legs syndrome ( 29029846) Urate levels in lean individuals ( 25811787)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	7 interacting genes: APP FBXO25 GMCL1 IRX5 LIG4 XRCC1 XRCC4
Entrez ID		26260	200558
HPRD ID		16439	09848
Ensembl ID		ENSG00000147364	ENSG00000169621
Uniprot IDs		Q8TCJ0	Q8IW19
PDB IDs			2KQB 2KQC 2KQD 2KQE 2KUO 5E50 5W7W 5W7X 5W7Y 6ERF 6TYT 6TYW 6TYZ 6YN1
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly	Base-excision Repair DNA Ligase IV Complex Double-strand Break Repair Via Nonhomologous End Joining DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Single Strand Break Repair Cellular Response To Lithium Ion Response To Lithium Ion V(D)J Recombination Cellular Response To Metal Ion Response To X-ray Neuron Maturation Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Double-strand Break Repair DNA Recombination Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Response To Metal Ion Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Establishment Of Integrated Proviral Latency Oxidized DNA Binding FHA Domain Binding Response To Radiation Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Establishment Of Viral Latency Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Nucleus Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DNA Ligase (ATP) Activity DNA Repair Ligase Activity DNA Ligase Activity
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