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FBXO25 and ORC4
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
FBXO25
ORC4
Description
F-box protein 25
origin recognition complex subunit 4
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleolus
Cytoplasm
SCF Ubiquitin Ligase Complex
Chromosome, Telomeric Region
Origin Recognition Complex
Nucleus
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Nucleolus
Cytoplasm
Cytosol
Molecular Function
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Nucleotide Binding
DNA Binding
DNA Replication Origin Binding
Protein Binding
ATP Binding
Biological Process
Protein Ubiquitination
DNA Replication
DNA Replication Initiation
Polar Body Extrusion After Meiotic Divisions
Protein Polymerization
Pathways
E2F-enabled inhibition of pre-replication complex formation
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Drugs
Diseases
Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS
Neonatal cytokine/chemokine levels (fetal genetic effect) (
30134952
)
Nontraumatic osteonecrosis of the femoral head (
32701715
)
Estimated glomerular filtration rate (
30604766
31015462
31152163
)
Loneliness (MTAG) (
29970889
)
Serum uric acid levels (
30993211
)
Urate levels (
31578528
)
Interacting Genes
82 interacting genes:
ANKRD13A
APLF
AXL
BMX
BRME1
CDK5RAP2
CDK9
CENPB
CHLSN
CUL1
CXXC4
DCX
DDX42
DEPTOR
DNAJB2
DNAJC8
DYRK3
DYRK4
EGFR
EID3
EIF4E2
ELK1
EPN1
FKBP3
G3BP1
GRK2
GTF2B
GTF2IRD2
HIP1
HMCES
HP1BP3
IL21
ILRUN
ING3
IRS1
JHY
KDR
KRT8
LMCD1
LUC7L
MAT2B
NKX2-5
NSRP1
NUAK1
ODF2
ORC4
PADI4
PAK4
PCK1
PDGFRA
PIP4K2C
PPID
PPP1R8
PRKCA
PRKG2
PRR15
PRRG1
PSMD4
RABEP2
RBM8A
RHBDD1
RIOK3
RPAP3
RPS10
RPS6KB2
SAMHD1
SERBP1
SKP1
STAC
SYTL2
TBX5
TCEAL2
TCEANC
TCP10L
TMA7
TNIP2
TRUB1
TWF1
UBE2D3
UBQLN1
UBQLN2
WDSUB1
28 interacting genes:
APP
CCND1
CDKN2A
CTBP1
FBXL5
FBXL8
FBXO25
FBXO6
H3-4
H4C16
KLHL20
KPNA1
MCM10
MCM2
MCM3
MCM4
MCM6
MCM7
MLH1
MTUS1
ORC1
ORC2
ORC3
ORC5
ORC6
RDH5
RRM2B
TCF4
Entrez ID
26260
5000
HPRD ID
16439
09118
Ensembl ID
ENSG00000147364
ENSG00000115947
Uniprot IDs
Q8TCJ0
A8K7H4
O43929
Q96B14
PDB IDs
5UJ7
5UJM
7CTE
7CTF
7CTG
7JPO
7JPP
7JPQ
7JPR
7JPS
8RWV
8S0C
8S0D
8S0E
8S0F
Enriched GO Terms of Interacting Partners
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Kinase Activity
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Nucleus
Polyubiquitin Modification-dependent Protein Binding
Cytosol
ATP Binding
Nucleotide Binding
Protein Phosphorylation
Phosphorylation
Protein Serine/threonine Kinase Activity
Apoptotic Process
Atrioventricular Node Cell Fate Commitment
Nucleoplasm
Cell Death
Programmed Cell Death
Cytoplasm
Protein Serine Kinase Activity
His-Purkinje System Cell Differentiation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Regulation Of Apoptotic Process
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Cardioblast Differentiation
Atrioventricular Node Cell Development
Bundle Of His Development
Vascular Endothelial Growth Factor Binding
Cellular Response To Stress
Regulation Of Programmed Cell Death
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Signal Transduction
Protein Metabolic Process
Vascular Endothelial Growth Factor Receptor Activity
Transferase Activity
Proteasomal Protein Catabolic Process
Cardiac Muscle Cell Fate Commitment
Cardiac Ventricle Formation
Negative Regulation Of Endothelial Cell Apoptotic Process
Ubiquitin Ligase Complex Scaffold Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Modification Process
Atrial Septum Development
Positive Regulation Of Natural Killer Cell Differentiation
Ubiquitin-modified Protein Reader Activity
ERAD Pathway
Regulation Of Cell Communication
Autophagosome Assembly
DNA Replication Initiation
DNA Replication
Nuclear Origin Of Replication Recognition Complex
Chromosome, Telomeric Region
Origin Recognition Complex
DNA Replication Origin Binding
DNA Metabolic Process
CMG Complex
MCM Complex
Double-strand Break Repair Via Break-induced Replication
Regulation Of DNA-templated DNA Replication Initiation
Single-stranded DNA Binding
Regulation Of DNA Replication
Nucleus
Mitotic DNA Replication Initiation
Single-stranded DNA Helicase Activity
Regulation Of DNA Metabolic Process
Chromosome
Nucleic Acid Metabolic Process
DNA Damage Response
DNA Helicase Activity
Nucleoplasm
DNA Repair
DNA Binding
Double-strand Break Repair
DNA Strand Elongation Involved In DNA Replication
ATP Hydrolysis Activity
Nucleobase-containing Compound Metabolic Process
Helicase Activity
DNA Recombination
Double-strand Break Repair Via Homologous Recombination
Macromolecule Metabolic Process
Recombinational Repair
DNA Strand Elongation
Cellular Response To Stress
DNA-templated DNA Replication
SCF Ubiquitin Ligase Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
Protein-DNA Complex Assembly
Mammary Gland Epithelial Cell Proliferation
Regulation Of Mammary Gland Epithelial Cell Proliferation
Enzyme Binding
Nucleolus
Regulation Of Cell Cycle Phase Transition
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Nucleosome Assembly
Cell Population Proliferation
Regulation Of Cell Cycle G2/M Phase Transition
Amyloid Fibril Formation
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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