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FBXO25 and ORC4
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
FBXO25
ORC4
Gene Name
F-box protein 25
origin recognition complex, subunit 4
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleolus
SCF Ubiquitin Ligase Complex
Origin Recognition Complex
Nucleus
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Nucleolus
Cytoplasm
Actin Cytoskeleton
Molecular Function
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Nucleotide Binding
DNA Replication Origin Binding
Protein Binding
ATP Binding
Biological Process
Protein Ubiquitination
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
DNA Replication Initiation
Pathways
G2/M Checkpoints
Activation of the pre-replicative complex
Activation of the pre-replicative complex
Orc1 removal from chromatin
Assembly of the pre-replicative complex
Activation of ATR in response to replication stress
G1/S Transition
Assembly of the ORC complex at the origin of replication
Removal of licensing factors from origins
Mitotic G1-G1/S phases
Switching of origins to a post-replicative state
E2F mediated regulation of DNA replication
Synthesis of DNA
DNA Replication Pre-Initiation
Regulation of DNA replication
M/G1 Transition
S Phase
CDC6 association with the ORC:origin complex
Cell Cycle, Mitotic
Orc1 removal from chromatin
E2F-enabled inhibition of pre-replication complex formation
Cell Cycle Checkpoints
Association of licensing factors with the pre-replicative complex
CDT1 association with the CDC6:ORC:origin complex
Drugs
Diseases
GWAS
Protein-Protein Interactions
80 interactors:
ADRBK1
ANKRD13A
APLF
AXL
BMX
C11orf63
C19orf57
C6orf106
C7orf50
CDK5RAP2
CDK9
CENPB
CUL1
CXXC4
DCX
DDX42
DEPTOR
DNAJB2
DNAJC8
DYRK3
DYRK4
EGFR
EID3
EIF4E2
ELK1
EPN1
FKBP3
G3BP1
GTF2B
GTF2IRD2
HIP1
HMCES
HP1BP3
IL21
ING3
IRS1
KDR
KRT8
LMCD1
LUC7L
MAT2B
NSRP1
NUAK1
ODF2
ORC4
PADI4
PAK4
PCK1
PDGFRA
PIP4K2C
PPID
PPP1R8
PRKCA
PRKG2
PRR15
PRRG1
PSMD4
RABEP2
RBM8A
RHBDD1
RIOK3
RPAP3
RPS10
RPS6KB2
SAMHD1
SERBP1
SKP1
STAC
SYTL2
TCEAL2
TCEANC
TCP10L
TMA7
TNIP2
TRUB1
TWF1
UBE2D3
UBQLN1
UBQLN2
WDSUB1
27 interactors:
APP
CCND1
CDKN2A
CTBP1
FBXL5
FBXL8
FBXO25
FBXO6
HIST3H3
HIST4H4
KPNA1
MCM10
MCM2
MCM3
MCM4
MCM6
MCM7
MLH1
MTUS1
ORC1
ORC2
ORC3
ORC5
ORC6
RPA2
RRM2B
TCF4
Entrez ID
26260
5000
HPRD ID
16439
09118
Ensembl ID
ENSG00000147364
ENSG00000115947
Uniprot IDs
Q8TCJ0
A8K7H4
O43929
Q96B14
PDB IDs
Enriched GO Terms of Interacting Partners
?
Regulation Of Metabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Peptidyl-amino Acid Modification
Cellular Metabolic Process
Cellular Protein Modification Process
Enzyme Linked Receptor Protein Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Response To Stress
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Innate Immune Response
Neurotrophin Signaling Pathway
Viral Process
Protein Phosphorylation
Cellular Response To Stimulus
Cellular Response To Growth Factor Stimulus
Fibroblast Growth Factor Receptor Signaling Pathway
Cellular Protein Metabolic Process
Response To Growth Factor
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Gene Expression
Peptidyl-tyrosine Phosphorylation
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Positive Regulation Of Phospholipase C Activity
Phosphorylation
Intracellular Signal Transduction
Regulation Of Cellular Process
Rhythmic Process
Protein Autophosphorylation
Positive Regulation Of Phospholipase Activity
Response To Stimulus
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Organic Substance
Immune Response
Proteasomal Protein Catabolic Process
G1/S Transition Of Mitotic Cell Cycle
Response To UV-A
Peptidyl-serine Autophosphorylation
Regulation Of Phospholipase Activity
Apoptotic Process
Positive Regulation Of Lipase Activity
Defense Response
Protein Metabolic Process
Regulation Of Cell Death
Immune System Process
Programmed Cell Death
Regulation Of Cellular Protein Metabolic Process
Cellular Macromolecule Catabolic Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA Metabolic Process
DNA-dependent DNA Replication
DNA Replication
DNA Replication Initiation
Cell Cycle Process
Cell Cycle
Mitotic Cell Cycle
Mitotic Cell Cycle Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Nitrogen Compound Metabolic Process
Chromosome Organization
DNA Unwinding Involved In DNA Replication
Cellular Macromolecule Biosynthetic Process
Cellular Metabolic Process
Macromolecule Biosynthetic Process
DNA Conformation Change
DNA Duplex Unwinding
DNA Geometric Change
Biosynthetic Process
Organelle Organization
Metabolic Process
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cellular Response To Stress
Regulation Of Cell Cycle G2/M Phase Transition
Protein-DNA Complex Assembly
Cellular Response To DNA Damage Stimulus
Regulation Of DNA Recombination
Telomere Maintenance
Regulation Of Mitotic Cell Cycle Phase Transition
Cell Proliferation
Regulation Of Cell Cycle Phase Transition
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Fat Cell Differentiation
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cellular Response To Epidermal Growth Factor Stimulus
Regulation Of Cell Cycle
Chromatin Assembly
Cellular Process
Cellular Macromolecular Complex Assembly
Response To Epidermal Growth Factor
Regulation Of Protein Export From Nucleus
Chromatin Assembly Or Disassembly
Tagcloud
?
archaeon
cctb
chec2
dpsa
elfa
fumc
gapb
halobacterium
halophilic
imd2
ipg
msra
nrc
ppia
rphs6
rpl18e
rpl31eand
rps27ae
shsp
thic
thid
tpia
trh5
uvrc
vng0683c
vng1300h
vng1807h
vng6254
yufn
Tagcloud (Difference)
?
archaeon
cctb
chec2
dpsa
elfa
fumc
gapb
halobacterium
halophilic
imd2
ipg
msra
nrc
ppia
rphs6
rpl18e
rpl31eand
rps27ae
shsp
thic
thid
tpia
trh5
uvrc
vng0683c
vng1300h
vng1807h
vng6254
yufn
Tagcloud (Intersection)
?