FBXO25 and SYTL2

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		FBXO25	SYTL2
Description		F-box protein 25	synaptotagmin like 2
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex	Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Melanosome Exocytic Vesicle
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatase Binding Small GTPase Binding Neurexin Family Protein Binding
	Biological Process	Protein Ubiquitination	Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Vesicle-mediated Transport
Pathways			Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)	Pallidum volume ( 31530798) Refractive error ( 32231278)
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	9 interacting genes: FBXO25 LNX1 MORN4 MTERF1 NRXN1 PPP1CA RAB27A RAB27B YIF1A
Entrez ID		26260	54843
HPRD ID		16439	10260
Ensembl ID		ENSG00000147364	ENSG00000137501
Uniprot IDs		Q8TCJ0	A0A0U1RR07 A0A8J9FM55 Q9HCH5
PDB IDs			3BC1 7OPP 7OPQ 7OPR 8P3G 8P3H 8P3I 8P3J 8P3K
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly	Myosin V Binding Multivesicular Body Membrane Exocytic Vesicle Multivesicular Body Sorting Pathway Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway Protein Localization To Synapse Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation G Protein Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Secretion By Cell GDP Binding Positive Regulation Of Exocytosis Protein Localization To Cell Junction Termination Of Mitochondrial Transcription Protein Complex Involved In Cell-cell Adhesion Guanylate Kinase-associated Protein Clustering Melanosome Secretory Granule Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Complement-dependent Cytotoxicity Positive Regulation Of Neuromuscular Synaptic Transmission Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Vesicle Localization Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Exosomal Secretion Secretion Negative Regulation Of Filopodium Assembly Glycogen Granule Late Endosome Establishment Of Protein Localization Weibel-Palade Body Platelet Dense Granule Membrane Cerebellar Granule Cell Differentiation Postsynaptic Density Protein 95 Clustering Neuronal Signal Transduction NMDA Selective Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Clustering Gamma-aminobutyric Acid Receptor Clustering Trans-synaptic Protein Complex Gephyrin Clustering Involved In Postsynaptic Density Assembly AMPA Selective Glutamate Receptor Signaling Pathway Neuroligin Family Protein Binding Type 1 Fibroblast Growth Factor Receptor Binding RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process
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