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MTNR1A and GNA13
Number of citations of the paper that reports this interaction (PMID
10598579
)
21
Data Source:
HPRD
(in vivo)
MTNR1A
GNA13
Gene Name
melatonin receptor 1A
guanine nucleotide binding protein (G protein), alpha 13
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Nucleus
Heterotrimeric G-protein Complex
Plasma Membrane
Focal Adhesion
Membrane
Brush Border Membrane
Melanosome
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Melatonin Receptor Activity
Hormone Binding
Organic Cyclic Compound Binding
GTPase Activity
Signal Transducer Activity
Protein Binding
GTP Binding
G-protein Beta/gamma-subunit Complex Binding
Type 1 Angiotensin Receptor Binding
D5 Dopamine Receptor Binding
Metal Ion Binding
Biological Process
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Mating Behavior
Circadian Rhythm
Positive Regulation Of CGMP Biosynthetic Process
Patterning Of Blood Vessels
In Utero Embryonic Development
Movement Of Cell Or Subcellular Component
Signal Transduction
Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Rho Protein Signal Transduction
Blood Coagulation
Regulation Of Cell Shape
Cell Differentiation
Platelet Activation
Regulation Of Cell Migration
Activation Of Phospholipase D Activity
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
GPCR downstream signaling
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
Thrombin signalling through proteinase activated receptors (PARs)
Signaling by GPCR
GPCR downstream signaling
Thromboxane signalling through TP receptor
G alpha (12/13) signalling events
Signal amplification
Platelet activation, signaling and aggregation
Drugs
Ramelteon
Melatonin
Agomelatine
Diseases
GWAS
Obesity (
21552555
)
Protein-Protein Interactions
26 interactors:
CALR
CANX
CNP
DPM1
EEF1G
FLNA
GNA11
GNA13
GNAI1
GNAI2
GNAI3
GNB1
GNB4
GPR50
HNRNPA0
HSPA5
IRS4
LRRC59
MTNR1B
PDIA6
PGRMC1
RAB10
RAC1
RAP1A
TMEM33
VAPB
31 interactors:
AIP
AKAP3
ARHGEF1
ARHGEF11
ARHGEF12
CDH1
CDH2
CTNNB1
CXCR4
DRD5
EDNRB
F2R
GNA12
GPR17
MCF2
MTNR1A
PPP5C
PRKACA
PRKCB
PRKCD
PRKCE
PTK2B
RDX
RGS16
RIC8A
S1PR2
S1PR3
S1PR4
TBXA2R
TGFBR1
TSHR
Entrez ID
4543
10672
HPRD ID
02812
05100
Ensembl ID
ENSG00000168412
ENSG00000120063
Uniprot IDs
P48039
B7Z7R0
F5H1G8
Q14344
PDB IDs
Enriched GO Terms of Interacting Partners
?
Platelet Activation
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Blood Coagulation
Hemostasis
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Regulation Of Body Fluid Levels
Wound Healing
Cell Activation
Response To Wounding
Signaling
Cell Communication
Response To Stimulus
G-protein Coupled Receptor Signaling Pathway
Signal Transduction
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Response To Organic Substance
Positive Regulation Of Nuclease Activity
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Kinase Activity
Vesicle-mediated Transport
Positive Regulation Of Transferase Activity
Response To Stress
Synaptic Transmission
Cell-cell Signaling
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Unfolded Protein
ER-nucleus Signaling Pathway
Cellular Response To Stimulus
Cellular Response To Topologically Incorrect Protein
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Kinase Activity
Dopamine Receptor Signaling Pathway
Substantia Nigra Development
Cellular Response To Organic Substance
Response To Unfolded Protein
Regulation Of Kinase Activity
Membrane Organization
Positive Regulation Of Phosphorylation
Response To Endoplasmic Reticulum Stress
Cell Surface Receptor Signaling Pathway
Neural Nucleus Development
Positive Regulation Of Protein Modification Process
Ras Protein Signal Transduction
Regulation Of Protein Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Kinase Activity
Response To Peptide Hormone
Midbrain Development
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Intracellular Signal Transduction
Signal Transduction
Positive Regulation Of Catalytic Activity
Cellular Calcium Ion Homeostasis
Calcium Ion Homeostasis
G-protein Coupled Receptor Signaling Pathway
Signaling
Regulation Of Signaling
Cell Communication
Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Cellular Response To Stimulus
Cytosolic Calcium Ion Homeostasis
Cellular Metal Ion Homeostasis
Cellular Cation Homeostasis
Cellular Ion Homeostasis
Metal Ion Homeostasis
Response To Organic Substance
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell Activation
Cellular Chemical Homeostasis
Ion Homeostasis
Apoptotic Process
Programmed Cell Death
Response To Stimulus
Positive Regulation Of Hydrolase Activity
Cellular Response To Organic Substance
Cell Death
Death
Chemical Homeostasis
Cellular Homeostasis
Regulation Of Cellular Process
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Intracellular Signal Transduction
Regulation Of Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Regulation Of MAPK Cascade
Platelet Activation
Homeostatic Process
Enzyme Linked Receptor Protein Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Negative Regulation Of Signaling
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Neurotrophin Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Termination Of Signal Transduction
Tagcloud
?
18q
19p13
1q
aberrations
arising
burkitt
collaborating
cooperate
copy
deep
enhancer
gains
id3
immunoglobulin
lymphoma
microrna
myc
next
profiling
recurrent
scope
sequencing
signatures
smarca4
subgroups
summary
transcriptome
widened
yielded
Tagcloud (Difference)
?
18q
19p13
1q
aberrations
arising
burkitt
collaborating
cooperate
copy
deep
enhancer
gains
id3
immunoglobulin
lymphoma
microrna
myc
next
profiling
recurrent
scope
sequencing
signatures
smarca4
subgroups
summary
transcriptome
widened
yielded
Tagcloud (Intersection)
?