MTNR1A and GNA13

Number of citations of the paper that reports this interaction (PMID 10598579)
21

Data Source:
HPRD (in vivo)

		MTNR1A	GNA13
Gene Name		melatonin receptor 1A	guanine nucleotide binding protein (G protein), alpha 13
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Nucleus Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Melatonin Receptor Activity Hormone Binding Organic Cyclic Compound Binding	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 1 Angiotensin Receptor Binding D5 Dopamine Receptor Binding Metal Ion Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Mating Behavior Circadian Rhythm Positive Regulation Of CGMP Biosynthetic Process	Patterning Of Blood Vessels In Utero Embryonic Development Movement Of Cell Or Subcellular Component Signal Transduction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Blood Coagulation Regulation Of Cell Shape Cell Differentiation Platelet Activation Regulation Of Cell Migration Activation Of Phospholipase D Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Thrombin signalling through proteinase activated receptors (PARs) Signaling by GPCR GPCR downstream signaling Thromboxane signalling through TP receptor G alpha (12/13) signalling events Signal amplification Platelet activation, signaling and aggregation
Drugs		Ramelteon Melatonin Agomelatine
Diseases
GWAS		Obesity ( 21552555)
Protein-Protein Interactions		26 interactors: CALR CANX CNP DPM1 EEF1G FLNA GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 HNRNPA0 HSPA5 IRS4 LRRC59 MTNR1B PDIA6 PGRMC1 RAB10 RAC1 RAP1A TMEM33 VAPB	31 interactors: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR
Entrez ID		4543	10672
HPRD ID		02812	05100
Ensembl ID		ENSG00000168412	ENSG00000120063
Uniprot IDs		P48039	B7Z7R0 F5H1G8 Q14344
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Signaling Cell Communication Response To Stimulus G-protein Coupled Receptor Signaling Pathway Signal Transduction Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Organic Substance Positive Regulation Of Nuclease Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Kinase Activity Vesicle-mediated Transport Positive Regulation Of Transferase Activity Response To Stress Synaptic Transmission Cell-cell Signaling Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Stimulus Cellular Response To Topologically Incorrect Protein Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Dopamine Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Organic Substance Response To Unfolded Protein Regulation Of Kinase Activity Membrane Organization Positive Regulation Of Phosphorylation Response To Endoplasmic Reticulum Stress Cell Surface Receptor Signaling Pathway Neural Nucleus Development Positive Regulation Of Protein Modification Process Ras Protein Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Response To Peptide Hormone Midbrain Development G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Catalytic Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Signaling Regulation Of Signaling Cell Communication Regulation Of Catalytic Activity Regulation Of Signal Transduction Cellular Response To Stimulus Cytosolic Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Activation Cellular Chemical Homeostasis Ion Homeostasis Apoptotic Process Programmed Cell Death Response To Stimulus Positive Regulation Of Hydrolase Activity Cellular Response To Organic Substance Cell Death Death Chemical Homeostasis Cellular Homeostasis Regulation Of Cellular Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Intracellular Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Platelet Activation Homeostatic Process Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Cellular Metabolic Process Termination Of Signal Transduction
Tagcloud ?			18q 19p13 1q aberrations arising burkitt collaborating cooperate copy deep enhancer gains id3 immunoglobulin lymphoma microrna myc next profiling recurrent scope sequencing signatures smarca4 subgroups summary transcriptome widened yielded
Tagcloud (Difference) ?			18q 19p13 1q aberrations arising burkitt collaborating cooperate copy deep enhancer gains id3 immunoglobulin lymphoma microrna myc next profiling recurrent scope sequencing signatures smarca4 subgroups summary transcriptome widened yielded
Tagcloud (Intersection) ?