MTNR1A and PDIA6

Number of citations of the paper that reports this interaction (PMID 17215244)
14

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MTNR1A	PDIA6
Gene Name		melatonin receptor 1A	protein disulfide isomerase family A, member 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Melatonin Receptor Activity Hormone Binding Organic Cyclic Compound Binding	Protein Disulfide Isomerase Activity Protein Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Mating Behavior Circadian Rhythm Positive Regulation Of CGMP Biosynthetic Process	Protein Folding Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress Apoptotic Cell Clearance Cellular Protein Metabolic Process Cell Redox Homeostasis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs		Ramelteon Melatonin Agomelatine
Diseases
GWAS		Obesity ( 21552555)
Protein-Protein Interactions		26 interactors: CALR CANX CNP DPM1 EEF1G FLNA GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 HNRNPA0 HSPA5 IRS4 LRRC59 MTNR1B PDIA6 PGRMC1 RAB10 RAC1 RAP1A TMEM33 VAPB	9 interactors: ATP13A2 CASP8 CLN8 CSNK2A1 MTNR1A MTNR1B SLC2A4 SUMO4 VKORC1
Entrez ID		4543	10130
HPRD ID		02812	07504
Ensembl ID		ENSG00000168412	ENSG00000143870
Uniprot IDs		P48039	Q15084
PDB IDs			1X5D 3VWW 3W8J 4EF0 4GWR
Enriched GO Terms of Interacting Partners?		Platelet Activation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Signaling Cell Communication Response To Stimulus G-protein Coupled Receptor Signaling Pathway Signal Transduction Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Organic Substance Positive Regulation Of Nuclease Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Kinase Activity Vesicle-mediated Transport Positive Regulation Of Transferase Activity Response To Stress Synaptic Transmission Cell-cell Signaling Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Stimulus Cellular Response To Topologically Incorrect Protein Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Dopamine Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Organic Substance Response To Unfolded Protein Regulation Of Kinase Activity Membrane Organization Positive Regulation Of Phosphorylation Response To Endoplasmic Reticulum Stress Cell Surface Receptor Signaling Pathway Neural Nucleus Development Positive Regulation Of Protein Modification Process Ras Protein Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Response To Peptide Hormone Midbrain Development G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process	Amylopectin Biosynthetic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development L-glutamate Uptake Involved In Synaptic Transmission TRAIL-activated Apoptotic Signaling Pathway Response To Ethanol Response To Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Tagcloud ?			brains contributions cpg dysregulation epigenome excessive gpr3 h3k4me3 hairy hd hes4 htt huntington hypermethylation jagged2 lastly mapping mark mash1 methylated modifying neurodegeneration prefrontal shrna split striatal strikingly tmem106b trimethyl
Tagcloud (Difference) ?			brains contributions cpg dysregulation epigenome excessive gpr3 h3k4me3 hairy hd hes4 htt huntington hypermethylation jagged2 lastly mapping mark mash1 methylated modifying neurodegeneration prefrontal shrna split striatal strikingly tmem106b trimethyl
Tagcloud (Intersection) ?