MTNR1A and CTPS2

Number of citations of the paper that reports this interaction (PubMedID 26514267)
0

Data Source:
BioGRID (two hybrid)

		MTNR1A	CTPS2
Description		melatonin receptor 1A	CTP synthase 2
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GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Nucleus Cytoplasm Mitochondrion Cytosol Cytoophidium
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity Hormone Binding	Nucleotide Binding CTP Synthase Activity Protein Binding ATP Binding Ligase Activity Identical Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mating Behavior Circadian Rhythm	Pyrimidine Nucleotide Metabolic Process Pyrimidine Nucleotide Biosynthetic Process CTP Biosynthetic Process Pyrimidine Nucleobase Biosynthetic Process 'de Novo' CTP Biosynthetic Process Small Molecule Metabolic Process
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Interconversion of nucleotide di- and triphosphates
Drugs		Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
Diseases
GWAS		Depressive symptoms measurement (somatic complaints domain) ( 26997408) Job-related exhaustion in shift workers ( 28364478) Mild obesity-related type 2 diabetes ( 34737425) Obesity ( 21552555)	Suicide ( 31476763)
Interacting Genes		160 interacting genes: ABHD14B ACTB ACTN1 AMOTL2 ANKRD12 ARHGAP28 ASAP3 ASCL1 ATIC ATP5MC3 BAG6 BAZ1A BAZ1B C10orf90 CALR CAND1 CANX CCDC167 CD99 CHD4 CIAO2B CIT CLASP1 CMIP CNP COG1 COL9A2 COMT COX11 CTNNA1 CTPS2 CUL3 CUL7 CYP27C1 CYSRT1 DDHD2 DDX52 DPM1 ECE1 ECE2 EEF1G EMC7 EMD ENO2 EPS15 EXOC1 F8A1 FAM241B FDXR FLNA FN1 FSTL1 GALNS GAPDH GATAD2B GBA2 GEMIN2 GFPT2 GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 H2AC6 HDAC10 HIVEP2 HMGN2 HMOX2 HNRNPA0 HNRNPH1 HSPA5 IPO9 IRS4 ITPR3 KLHL12 KLHL20 KLHL5 KPNB1 KRTAP1-3 KRTAP10-8 LAPTM4A LIPE LPP LRP3 LRRC59 MAMLD1 MCC MESD MMP2 MMS19 MPDZ MTNR1B MYO9A NAP1L1 NAP1L4 NAP1L5 NASP PAXIP1 PCDHB10 PDIA6 PEX14 PGRMC1 PKD1L2 PPP2R3C PRELID1 PSMD2 PSME4 PTPN13 PTPRD PTX3 RAB10 RAC1 RACK1 RAP1A RBM39 RGS12 RNF2 RNF41 RPL3 RTRAF SLC2A3 SLC30A1 SLC6A3 SLIT1 SNAPIN SOX11 SRI STXBP1 SUCLA2 SURF4 SVEP1 TLN1 TM9SF1 TMEM14A TMEM230 TMEM33 TMX2 TPP2 TRIP12 TUBB TVP23B UBA1 UBAP2L UBQLN1 UBR4 USP28 USP32 USP34 VAPB VARS1 WAPL WASHC4 YWHAB YWHAZ ZC3H11A ZDHHC16 ZNF460	6 interacting genes: CTBP2 FGFR1 MTNR1A RPL23A RPL37A SPG21
Entrez ID		4543	56474
HPRD ID		02812	02305
Ensembl ID		ENSG00000168412	ENSG00000047230
Uniprot IDs		P48039	Q9NRF8
PDB IDs		6ME2 6ME3 6ME4 6ME5 7DB6 7VGY 7VGZ	2V4U 2VKT 3IHL 6PK4 6PK7 7MH1 7MIH 7MII
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Cytosol Heterotrimeric G-protein Complex Focal Adhesion Melanosome Guanyl Nucleotide Binding Membrane G-protein Beta/gamma-subunit Complex Binding Cadherin Binding Homotypic Cell-cell Adhesion Regulation Of Organelle Organization Proteasomal Protein Catabolic Process G Protein Activity Regulation Of Cellular Component Organization Cytoplasm G Protein-coupled Receptor Binding Platelet Aggregation Diacylglycerol Lipase Activity Protein Binding Vinculin Binding Cellular Localization Protein Folding In Endoplasmic Reticulum Regulation Of Biological Quality Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process GTPase Activity Negative Regulation Of Vasoconstriction Proteolysis Neural Nucleus Development Establishment Of Protein Localization Protein Metabolic Process Negative Regulation Of Synapse Organization Cullin-RING Ubiquitin Ligase Complex Nucleoplasm Nucleosomal DNA Binding Protein-containing Complex Binding Melatonin Receptor Activity	Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Vitamin D3 Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of Mitotic Cell Cycle DNA Replication Receptor-receptor Interaction Ventricular Zone Neuroblast Division Regulation Of Mitotic Cell Cycle DNA Replication Developmental Maturation Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Cementum Mineralization Diphosphate Metabolic Process Fibroblast Growth Factor Receptor Activity Cell Maturation Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Orbitofrontal Cortex Development Negative Regulation Of Fibroblast Growth Factor Production Macromolecule Biosynthetic Process Receptor Complex Positive Regulation Of Phospholipase Activity Forebrain Neuroblast Division Regulation Of Lateral Mesodermal Cell Fate Specification Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Parathyroid Hormone Secretion Melatonin Receptor Activity Ribosome Cytoplasmic Translation Cytosolic Ribosome Cytosolic Large Ribosomal Subunit TORC2 Complex Binding Structural Constituent Of Ribosome Auditory Receptor Cell Development Positive Regulation Of Nuclear Cell Cycle DNA Replication Lung-associated Mesenchyme Development Regulation Of Branching Involved In Salivary Gland Morphogenesis Outer Ear Morphogenesis Positive Regulation Of Lipase Activity Regulation Of Mesodermal Cell Differentiation Mesenchymal-epithelial Cell Signaling Paraxial Mesoderm Development Response To Sodium Phosphate Regulation Of Phosphate Transport CD4 Receptor Binding Salivary Gland Morphogenesis Gene Expression Branching Involved In Salivary Gland Morphogenesis Regulation Of Nuclear Cell Cycle DNA Replication Vitamin D Metabolic Process Inner Ear Receptor Cell Development Ear Development Regulation Of Retinoic Acid Receptor Signaling Pathway
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