GNA13 and AKAP3

Number of citations of the paper that reports this interaction (PubMedID 11696326)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro, two hybrid)

		GNA13	AKAP3
Description		G protein subunit alpha 13	A-kinase anchoring protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Exosome Postsynapse	Acrosomal Vesicle Nucleus Cytoplasm Cilium Cytoplasmic Vesicle Motile Cilium Sperm Fibrous Sheath Cell Projection Sperm Midpiece Sperm Principal Piece
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding	Protein Binding Protein Kinase A Binding
	Biological Process	Angiogenesis Branching Involved In Blood Vessel Morphogenesis In Utero Embryonic Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Blood Pressure Regulation Of Cell Shape Regulation Of Fibroblast Migration Cell Differentiation Platelet Activation Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Assembly Rho-activating G Protein-coupled Receptor Signaling Pathway	Blastocyst Hatching Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Single Fertilization Acrosome Reaction Intracellular Protein Localization Flagellated Sperm Motility Establishment Of Protein Localization
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Thromboxane signalling through TP receptor Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Periventricular white matter hyperintensities ( 32517579) White matter microstructure (global fractional anisotropy) ( 24736177)	Gut microbiota (bacterial taxa) ( 27723756)
Interacting Genes		31 interacting genes: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR	8 interacting genes: AKAP4 BRAP GNA13 PRKAR2A ROPN1 ROPN1B ROPN1L SPA17
Entrez ID		10672	10566
HPRD ID		05100	05256
Ensembl ID		ENSG00000120063	ENSG00000111254
Uniprot IDs		Q14344	O75969 V9HWD4
PDB IDs		7SF7 7SF8 7T6B 7YDH 8H8J 8KGG 8ZX4 8ZX5 9GE2 9GE3 9IY8 9IZH
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Membrane G Protein-coupled Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Oxygen-containing Compound Intracellular Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette G Protein-coupled Receptor Binding Sphingosine-1-phosphate Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Vasculature Development Peptidyl-serine Phosphorylation Positive Regulation Of Signal Transduction Modulation Of Chemical Synaptic Transmission Guanyl-nucleotide Exchange Factor Activity Sphingosine-1-phosphate Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Sphingolipid Mediated Signaling Pathway Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Lipid Cell Motility Regulation Of Multicellular Organismal Process Regulation Of Blood Pressure Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Catenin Complex Cell Surface Receptor Signaling Pathway Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity G-protein Alpha-subunit Binding Cell Migration Lamellipodium Regulation Of Protein Localization Regulation Of Vasculature Development Regulation Of Developmental Process Cellular Response To Indole-3-methanol	Cilium Movement Motile Cilium Sperm Capacitation Sperm Motility Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility Microtubule-based Movement Cilium Sperm Fibrous Sheath CAMP-dependent Protein Kinase Complex Microtubule-based Process Developmental Process Involved In Reproduction Cell Maturation Sperm Principal Piece Developmental Maturation Reproductive Process Small GTPase-mediated Signal Transduction Epithelial Cilium Movement Involved In Extracellular Fluid Movement Extracellular Transport Cilium Organization Protein Localization To Cilium Rho Protein Signal Transduction Cytoplasm Cell Motility D5 Dopamine Receptor Binding Single Fertilization Male Gamete Generation Spermatogenesis Sperm End Piece Gamete Generation Cell Projection Fertilization Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Rho-activating G Protein-coupled Receptor Signaling Pathway CAMP-dependent Protein Kinase Regulator Activity Microtubule-based Transport CAMP-dependent Protein Kinase Inhibitor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Nucleotide-activated Protein Kinase Complex Intracellular Signal Transduction Intracellular Signaling Cassette Radial Spoke Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Catalytic Subunit Binding Sperm Head-tail Coupling Apparatus Guanyl Nucleotide Binding Acrosome Reaction Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Sperm Flagellum Assembly
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