MTNR1A and UBR4

Number of citations of the paper that reports this interaction (PubMedID 26514267)
0

Data Source:
BioGRID (two hybrid)

		MTNR1A	UBR4
Description		melatonin receptor 1A	ubiquitin protein ligase E3 component n-recognin 4
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity Hormone Binding	Ubiquitin-protein Transferase Activity Protein Binding Calmodulin Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mating Behavior Circadian Rhythm	Cytoplasmic Translation Translational Initiation Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Fatty Acid Biosynthetic Process Response To Oxidative Stress Endosome Organization Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Protein Ubiquitination Protein Catabolic Process Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K27-linked Ubiquitination Negative Regulation Of Fatty Acid Biosynthetic Process Protein Stabilization Type I Interferon-mediated Signaling Pathway Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Targeting To Vacuole Involved In Autophagy Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Cytoplasm Protein Quality Control HRI-mediated Signaling Negative Regulation Of HRI-mediated Signaling Protein Branched Polyubiquitination
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon	Verpasep caltespen Picolinic acid
Diseases
GWAS		Depressive symptoms measurement (somatic complaints domain) ( 26997408) Job-related exhaustion in shift workers ( 28364478) Mild obesity-related type 2 diabetes ( 34737425) Obesity ( 21552555)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Composite immunoglobulin trait (IgA/IgG) ( 28628107)
Interacting Genes		160 interacting genes: ABHD14B ACTB ACTN1 AMOTL2 ANKRD12 ARHGAP28 ASAP3 ASCL1 ATIC ATP5MC3 BAG6 BAZ1A BAZ1B C10orf90 CALR CAND1 CANX CCDC167 CD99 CHD4 CIAO2B CIT CLASP1 CMIP CNP COG1 COL9A2 COMT COX11 CTNNA1 CTPS2 CUL3 CUL7 CYP27C1 CYSRT1 DDHD2 DDX52 DPM1 ECE1 ECE2 EEF1G EMC7 EMD ENO2 EPS15 EXOC1 F8A1 FAM241B FDXR FLNA FN1 FSTL1 GALNS GAPDH GATAD2B GBA2 GEMIN2 GFPT2 GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 H2AC6 HDAC10 HIVEP2 HMGN2 HMOX2 HNRNPA0 HNRNPH1 HSPA5 IPO9 IRS4 ITPR3 KLHL12 KLHL20 KLHL5 KPNB1 KRTAP1-3 KRTAP10-8 LAPTM4A LIPE LPP LRP3 LRRC59 MAMLD1 MCC MESD MMP2 MMS19 MPDZ MTNR1B MYO9A NAP1L1 NAP1L4 NAP1L5 NASP PAXIP1 PCDHB10 PDIA6 PEX14 PGRMC1 PKD1L2 PPP2R3C PRELID1 PSMD2 PSME4 PTPN13 PTPRD PTX3 RAB10 RAC1 RACK1 RAP1A RBM39 RGS12 RNF2 RNF41 RPL3 RTRAF SLC2A3 SLC30A1 SLC6A3 SLIT1 SNAPIN SOX11 SRI STXBP1 SUCLA2 SURF4 SVEP1 TLN1 TM9SF1 TMEM14A TMEM230 TMEM33 TMX2 TPP2 TRIP12 TUBB TVP23B UBA1 UBAP2L UBQLN1 UBR4 USP28 USP32 USP34 VAPB VARS1 WAPL WASHC4 YWHAB YWHAZ ZC3H11A ZDHHC16 ZNF460	18 interacting genes: ACE2 ADRA1A AGTR1 CALM1 ERG HSPA13 MTNR1A MTNR1B MYCN PRPF40A SRGN SRPK2 SUMO2 TTC3 UBC UBE2B UBE2D2 UBE2L3
Entrez ID		4543	23352
HPRD ID		02812	10184
Ensembl ID		ENSG00000168412	ENSG00000127481
Uniprot IDs		P48039	Q5T4S7
PDB IDs		6ME2 6ME3 6ME4 6ME5 7DB6 7VGY 7VGZ	8B5W 8BTL 8J9Q 8J9R
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Cytosol Heterotrimeric G-protein Complex Focal Adhesion Melanosome Guanyl Nucleotide Binding Membrane G-protein Beta/gamma-subunit Complex Binding Cadherin Binding Homotypic Cell-cell Adhesion Regulation Of Organelle Organization Proteasomal Protein Catabolic Process G Protein Activity Regulation Of Cellular Component Organization Cytoplasm G Protein-coupled Receptor Binding Platelet Aggregation Diacylglycerol Lipase Activity Protein Binding Vinculin Binding Cellular Localization Protein Folding In Endoplasmic Reticulum Regulation Of Biological Quality Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process GTPase Activity Negative Regulation Of Vasoconstriction Proteolysis Neural Nucleus Development Establishment Of Protein Localization Protein Metabolic Process Negative Regulation Of Synapse Organization Cullin-RING Ubiquitin Ligase Complex Nucleoplasm Nucleosomal DNA Binding Protein-containing Complex Binding Melatonin Receptor Activity	Regulation Of Vasoconstriction Regulation Of Blood Circulation Melatonin Receptor Activity Ubiquitin Conjugating Enzyme Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Action Potential Positive Regulation Of Cardiac Muscle Contraction Protein Modification By Small Protein Conjugation Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Nucleoplasm Positive Regulation Of Striated Muscle Contraction Regulation Of Cardiac Muscle Contraction Protein Modification Process Proteolysis Protein Tag Activity Ubiquitin-protein Transferase Activity Vascular Process In Circulatory System Regulation Of Striated Muscle Contraction Post-translational Protein Modification Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin-like Protein Transferase Activity Regulation Of System Process Protein Metabolic Process Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Circulatory System Process Protein Ubiquitination Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Reactive Oxygen Species Metabolic Process Presynaptic Cytosol G Protein-coupled Receptor Activity Proteolysis Involved In Protein Catabolic Process Regulation Of Muscle Contraction Regulation Of Blood Pressure Positive Regulation Of Heart Contraction Protein K11-linked Ubiquitination G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure Angiotensin Type I Receptor Activity Maintenance Of Granzyme B Location In T Cell Secretory Granule Maintenance Of Protease Location In Mast Cell Secretory Granule T Cell Secretory Granule Organization Regulation Of Heart Contraction Positive Regulation Of Muscle Contraction G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine
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