GNA13 and CXCR4

Number of citations of the paper that reports this interaction (PubMedID 23773523)
50

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GNA13	CXCR4
Description		G protein subunit alpha 13	C-X-C motif chemokine receptor 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Exosome Postsynapse	Cytoplasm Lysosome Endosome Early Endosome Late Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Extracellular Exosome Anchoring Junction
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding	Virus Receptor Activity Actin Binding G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Cytokine Binding C-C Chemokine Binding Ubiquitin Protein Ligase Binding Myosin Light Chain Binding C-X-C Motif Chemokine 12 Receptor Activity Ubiquitin Binding
	Biological Process	Angiogenesis Branching Involved In Blood Vessel Morphogenesis In Utero Embryonic Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Blood Pressure Regulation Of Cell Shape Regulation Of Fibroblast Migration Cell Differentiation Platelet Activation Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Assembly Rho-activating G Protein-coupled Receptor Signaling Pathway	Response To Hypoxia Dendritic Cell Chemotaxis Apoptotic Process Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Brain Development Response To Virus Cell Migration Calcium-mediated Signaling Neurogenesis Regulation Of Cell Adhesion Regulation Of Cell Migration Positive Regulation Of Cell Migration CXCL12-activated CXCR4 Signaling Pathway Myelin Maintenance Symbiont Entry Into Host Cell Positive Regulation Of Oligodendrocyte Differentiation Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vasculature Development Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Thromboxane signalling through TP receptor Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) CDC42 GTPase cycle RAC1 GTPase cycle	Binding and entry of HIV virion Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events Formation of definitive endoderm Specification of primordial germ cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs			Baclofen Framycetin AMD-070 Plerixafor Ulocuplumab Ibalizumab MSX-122
Diseases			Chemokine receptor defect, including the following disease: WHIM syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Periventricular white matter hyperintensities ( 32517579) White matter microstructure (global fractional anisotropy) ( 24736177)	Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arthritis (juvenile idiopathic) ( 27005825) Attention deficit hyperactivity disorder ( 32595297) Body mass index ( 26426971) Colorectal cancer ( 29228715) Estimated glomerular filtration rate ( 31152163) Lung function (low FEV1 vs high FEV1) ( 26423011) Monocyte count ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 19525953 31604244) Non-albumin protein levels ( 29403010) Smoking status (ever vs never smokers) ( 30643258) Telomere length ( 20421499) White blood cell count ( 32888494)
Interacting Genes		31 interacting genes: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR	34 interacting genes: ARRB2 ATP13A2 B2M CCR5 CD4 CTSG CXCL12 DPP4 DUXAP9 ELANE GNA13 GNAI1 GRK3 HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC RNF113A SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1
Entrez ID		10672	7852
HPRD ID		05100	01217
Ensembl ID		ENSG00000120063	ENSG00000121966
Uniprot IDs		Q14344	A0A0U3FJG0 A0A0U3GXA9 A0A8Q3WLL1 P61073
PDB IDs		7SF7 7SF8 7T6B 7YDH 8H8J 8KGG 8ZX4 8ZX5 9GE2 9GE3 9IY8 9IZH	2K03 2K04 2K05 2N55 3ODU 3OE0 3OE6 3OE8 3OE9 4RWS 8GP3 8I0Q 8K3Z 8U4N 8U4O 8U4P 8U4Q 8U4R 8U4S 8U4T 8YU7 8ZPL 8ZPM 8ZPN
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Membrane G Protein-coupled Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Oxygen-containing Compound Intracellular Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette G Protein-coupled Receptor Binding Sphingosine-1-phosphate Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Vasculature Development Peptidyl-serine Phosphorylation Positive Regulation Of Signal Transduction Modulation Of Chemical Synaptic Transmission Guanyl-nucleotide Exchange Factor Activity Sphingosine-1-phosphate Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Sphingolipid Mediated Signaling Pathway Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Lipid Cell Motility Regulation Of Multicellular Organismal Process Regulation Of Blood Pressure Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Catenin Complex Cell Surface Receptor Signaling Pathway Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity G-protein Alpha-subunit Binding Cell Migration Lamellipodium Regulation Of Protein Localization Regulation Of Vasculature Development Regulation Of Developmental Process Cellular Response To Indole-3-methanol	Regulation Of Cell-cell Adhesion Cytokine-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Via STAT Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Growth Hormone Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Adhesion Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Activation Regulation Of Defense Response Positive Regulation Of T Cell Activation Response To Stress Defense Response Positive Regulation Of Immune System Process Interleukin-9-mediated Signaling Pathway Negative Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Response To Other Organism Cell Activation Immune System Process Negative Regulation Of Leukocyte Cell-cell Adhesion Response To External Biotic Stimulus Regulation Of Cytokine Production Interleukin-15-mediated Signaling Pathway Leukocyte Activation Positive Regulation Of Lymphocyte Activation Regulation Of T Cell Proliferation Cell Migration Regulation Of Leukocyte Proliferation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Population Proliferation Negative Regulation Of Leukocyte Activation Positive Regulation Of Cell Activation Leukocyte Mediated Cytotoxicity T Cell Activation Negative Regulation Of T Cell Activation Positive Regulation Of Immune Response Regulation Of Developmental Process Interleukin-6-mediated Signaling Pathway Regulation Of Multicellular Organismal Process
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