MTNR1A and TMEM33

Number of citations of the paper that reports this interaction (PMID 17215244)
14

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MTNR1A	TMEM33
Gene Name		melatonin receptor 1A	transmembrane protein 33
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Integral Component Of Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Melatonin Receptor Activity Hormone Binding Organic Cyclic Compound Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Mating Behavior Circadian Rhythm Positive Regulation Of CGMP Biosynthetic Process	Biological_process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Ramelteon Melatonin Agomelatine
Diseases
GWAS		Obesity ( 21552555)
Protein-Protein Interactions		26 interactors: CALR CANX CNP DPM1 EEF1G FLNA GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 HNRNPA0 HSPA5 IRS4 LRRC59 MTNR1B PDIA6 PGRMC1 RAB10 RAC1 RAP1A TMEM33 VAPB	2 interactors: MTNR1A RPS14
Entrez ID		4543	55161
HPRD ID		02812	07680
Ensembl ID		ENSG00000168412	ENSG00000109133
Uniprot IDs		P48039	P57088
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Signaling Cell Communication Response To Stimulus G-protein Coupled Receptor Signaling Pathway Signal Transduction Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Organic Substance Positive Regulation Of Nuclease Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Kinase Activity Vesicle-mediated Transport Positive Regulation Of Transferase Activity Response To Stress Synaptic Transmission Cell-cell Signaling Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Stimulus Cellular Response To Topologically Incorrect Protein Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Dopamine Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Organic Substance Response To Unfolded Protein Regulation Of Kinase Activity Membrane Organization Positive Regulation Of Phosphorylation Response To Endoplasmic Reticulum Stress Cell Surface Receptor Signaling Pathway Neural Nucleus Development Positive Regulation Of Protein Modification Process Ras Protein Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Response To Peptide Hormone Midbrain Development G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?			1a 2b 3c 4c arl6ip1 cisternae elaborate elucidated envelope er exogenously harboring homology interconnected localizes organelle potency reticulon reticulons shaped shaping sheet sheets suppress suppresses transmembrane tubular tubulation tubules
Tagcloud (Difference) ?			1a 2b 3c 4c arl6ip1 cisternae elaborate elucidated envelope er exogenously harboring homology interconnected localizes organelle potency reticulon reticulons shaped shaping sheet sheets suppress suppresses transmembrane tubular tubulation tubules
Tagcloud (Intersection) ?