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MTNR1A and VAPB
Number of citations of the paper that reports this interaction (PMID
17215244
)
14
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
MTNR1A
VAPB
Gene Name
melatonin receptor 1A
VAMP (vesicle-associated membrane protein)-associated protein B and C
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Golgi Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Integral Component Of Membrane
Endoplasmic Reticulum Exit Site
Molecular Function
Protein Binding
Melatonin Receptor Activity
Hormone Binding
Organic Cyclic Compound Binding
Protein Binding
Microtubule Binding
Enzyme Binding
FFAT Motif Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Beta-tubulin Binding
Biological Process
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Mating Behavior
Circadian Rhythm
Positive Regulation Of CGMP Biosynthetic Process
Sphingolipid Metabolic Process
Cellular Calcium Ion Homeostasis
ER To Golgi Vesicle-mediated Transport
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Endoplasmic Reticulum Organization
Modulation By Virus Of Host Morphology Or Physiology
Sphingolipid Biosynthetic Process
Endoplasmic Reticulum Unfolded Protein Response
Small Molecule Metabolic Process
Negative Regulation By Host Of Viral Release From Host Cell
Positive Regulation By Host Of Viral Release From Host Cell
Negative Regulation By Host Of Viral Genome Replication
Positive Regulation By Host Of Viral Genome Replication
Positive Regulation Of Viral Genome Replication
Negative Regulation By Virus Of Viral Protein Levels In Host Cell
COPII-coated Vesicle Budding
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
GPCR downstream signaling
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
Sphingolipid metabolism
Metabolism of lipids and lipoproteins
Sphingolipid de novo biosynthesis
Drugs
Ramelteon
Melatonin
Agomelatine
Diseases
GWAS
Obesity (
21552555
)
Protein-Protein Interactions
26 interactors:
CALR
CANX
CNP
DPM1
EEF1G
FLNA
GNA11
GNA13
GNAI1
GNAI2
GNAI3
GNB1
GNB4
GPR50
HNRNPA0
HSPA5
IRS4
LRRC59
MTNR1B
PDIA6
PGRMC1
RAB10
RAC1
RAP1A
TMEM33
VAPB
15 interactors:
FAF1
GPR25
MTNR1A
OSBPL2
RMDN2
STX1A
STX2
STX4
STX5
USP20
VAMP1
VAMP2
VAPA
VHL
VKORC1
Entrez ID
4543
9217
HPRD ID
02812
09300
Ensembl ID
ENSG00000168412
ENSG00000124164
Uniprot IDs
P48039
O95292
Q53XM7
PDB IDs
3IKK
Enriched GO Terms of Interacting Partners
?
Platelet Activation
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Blood Coagulation
Hemostasis
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Regulation Of Body Fluid Levels
Wound Healing
Cell Activation
Response To Wounding
Signaling
Cell Communication
Response To Stimulus
G-protein Coupled Receptor Signaling Pathway
Signal Transduction
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Response To Organic Substance
Positive Regulation Of Nuclease Activity
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Kinase Activity
Vesicle-mediated Transport
Positive Regulation Of Transferase Activity
Response To Stress
Synaptic Transmission
Cell-cell Signaling
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Unfolded Protein
ER-nucleus Signaling Pathway
Cellular Response To Stimulus
Cellular Response To Topologically Incorrect Protein
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Kinase Activity
Dopamine Receptor Signaling Pathway
Substantia Nigra Development
Cellular Response To Organic Substance
Response To Unfolded Protein
Regulation Of Kinase Activity
Membrane Organization
Positive Regulation Of Phosphorylation
Response To Endoplasmic Reticulum Stress
Cell Surface Receptor Signaling Pathway
Neural Nucleus Development
Positive Regulation Of Protein Modification Process
Ras Protein Signal Transduction
Regulation Of Protein Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Kinase Activity
Response To Peptide Hormone
Midbrain Development
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Vesicle Fusion
Membrane Fusion
Organelle Fusion
Vesicle Organization
Synaptic Vesicle Fusion To Presynaptic Membrane
Synaptic Vesicle Exocytosis
Vesicle Docking
Membrane Docking
Membrane Organization
Vesicle-mediated Transport
Neurotransmitter Secretion
Synaptic Vesicle Transport
Exocytosis
Regulation Of Neurotransmitter Levels
Calcium Ion-dependent Exocytosis
Neurotransmitter Transport
Cellular Protein Localization
Establishment Of Vesicle Localization
Vesicle Localization
Secretion By Cell
Golgi Vesicle Transport
SNARE Complex Assembly
Cellular Localization
Secretion
Establishment Of Organelle Localization
Positive Regulation Of Synaptic Transmission
Protein Localization
Establishment Of Localization In Cell
Organelle Localization
Response To Hydroperoxide
Glutamate Secretion
Regulation Of Exocytosis
Intracellular Protein Transport
Intracellular Transport
Regulation Of Insulin Secretion
Pathogenesis
Regulation Of Peptide Hormone Secretion
Synaptic Transmission
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Protein Transport
Long-term Synaptic Potentiation
Regulation Of Hormone Secretion
Regulation Of Establishment Of Protein Localization
Transport
Acid Secretion
Positive Regulation Of Exocytosis
Regulation Of Synaptic Transmission
Protein Transport
Regulation Of Protein Localization
Organelle Organization
Tagcloud
?
2alpha
bip
centrally
chaperone
chlamydia
chlamydiae
chlamydial
cpn
eif2alpha
endoplasmic
er
eukaryotic
exogenous
gamma
grp78
ifn
inclusions
inducer
interacted
interplay
maintain
persistent
pneumoniae
productive
restore
reticulum
unfolded
upr
vesicle
Tagcloud (Difference)
?
2alpha
bip
centrally
chaperone
chlamydia
chlamydiae
chlamydial
cpn
eif2alpha
endoplasmic
er
eukaryotic
exogenous
gamma
grp78
ifn
inclusions
inducer
interacted
interplay
maintain
persistent
pneumoniae
productive
restore
reticulum
unfolded
upr
vesicle
Tagcloud (Intersection)
?