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GNA13 and CDH1
Number of citations of the paper that reports this interaction (PubMedID
11136230
)
34
Data Source:
HPRD
(two hybrid, in vitro)
GNA13
CDH1
Description
G protein subunit alpha 13
cadherin 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Heterotrimeric G-protein Complex
Plasma Membrane
Focal Adhesion
Membrane
Brush Border Membrane
Melanosome
Extracellular Exosome
Postsynapse
Extracellular Region
Cytoplasm
Endosome
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Adherens Junction
Cytoplasmic Side Of Plasma Membrane
Actin Cytoskeleton
Membrane
Lateral Plasma Membrane
Catenin Complex
Flotillin Complex
Lamellipodium
Cell Junction
Desmosome
Cortical Actin Cytoskeleton
Apical Junction Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Anchoring Junction
Postsynapse
Glutamatergic Synapse
Molecular Function
Nucleotide Binding
G Protein-coupled Receptor Binding
GTPase Activity
G Protein Activity
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
GTP Binding
Guanyl Nucleotide Binding
G-protein Beta/gamma-subunit Complex Binding
D5 Dopamine Receptor Binding
Metal Ion Binding
Calcium Ion Binding
Protein Binding
Beta-catenin Binding
Ankyrin Binding
GTPase Activating Protein Binding
Identical Protein Binding
Gamma-catenin Binding
Cadherin Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Cell-cell Adhesion Mediator Activity
Protein Tyrosine Kinase Binding
Biological Process
Angiogenesis
Branching Involved In Blood Vessel Morphogenesis
In Utero Embryonic Development
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Rho Protein Signal Transduction
Regulation Of Blood Pressure
Regulation Of Cell Shape
Regulation Of Fibroblast Migration
Cell Differentiation
Platelet Activation
Intracellular Signal Transduction
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Postsynapse Assembly
Rho-activating G Protein-coupled Receptor Signaling Pathway
Cell Morphogenesis
Desmosome Assembly
Cell-cell Junction Assembly
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Synapse Assembly
Response To Xenobiotic Stimulus
Response To Toxic Substance
Regulation Of Gene Expression
Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Cell Migration
Pituitary Gland Development
Negative Regulation Of Cell-cell Adhesion
Negative Regulation Of Cell Migration
Negative Regulation Of Axon Extension
Neuron Projection Development
Cell Junction Assembly
Adherens Junction Organization
Positive Regulation Of Protein Import Into Nucleus
Cell-cell Adhesion Mediated By Cadherin
Positive Regulation Of DNA-templated Transcription
Regulation Of Transport
Cellular Response To Lithium Ion
Response To Heparin
Cellular Response To Indole-3-methanol
Protein Localization To Plasma Membrane
Cell-cell Adhesion
Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Response To Gram-positive Bacterium
Positive Regulation Of Protein Localization
Pathways
NRAGE signals death through JNK
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
Thrombin signalling through proteinase activated receptors (PARs)
Thrombin signalling through proteinase activated receptors (PARs)
CDC42 GTPase cycle
RAC1 GTPase cycle
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Apoptotic cleavage of cell adhesion proteins
Adherens junctions interactions
RHO GTPases activate IQGAPs
InlA-mediated entry of Listeria monocytogenes into host cells
Regulation of CDH1 Function
Regulation of CDH1 mRNA translation by microRNAs
Degradation of CDH1
Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Formation of definitive endoderm
Transcriptional and post-translational regulation of MITF-M expression and activity
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Myoepithelial Cells
Developmental Lineage of Mammary Stem Cells
Drugs
Diseases
Penile cancer
Breast cancer
Gastric cancer
Nasopharyngeal cancer
Hepatocellular carcinoma
Thyroid cancer
GWAS
Brain morphology (MOSTest) (
32665545
)
Periventricular white matter hyperintensities (
32517579
)
White matter microstructure (global fractional anisotropy) (
24736177
)
Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease (
34020725
)
Colorectal cancer (
19011631
)
Colorectal cancer or advanced adenoma (
30510241
)
Cutaneous malignant melanoma (
26237428
32341527
)
Glycated hemoglobin levels (
34059833
)
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Immature fraction of reticulocytes (
32888494
)
Late-onset Alzheimer's disease (
27770636
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Nevus count or cutaneous melanoma (
32341527
)
Red cell distribution width (
32888494
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Ulcerative colitis (
19915572
)
Interacting Genes
31 interacting genes:
AIP
AKAP3
ARHGEF1
ARHGEF11
ARHGEF12
CDH1
CDH2
CTNNB1
CXCR4
DRD5
EDNRB
F2R
GNA12
GPR17
MCF2
MTNR1A
PPP5C
PRKACA
PRKCB
PRKCD
PRKCE
PTK2B
RDX
RGS16
RIC8A
S1PR2
S1PR3
S1PR4
TBXA2R
TGFBR1
TSHR
74 interacting genes:
ACTR3
AKT1
ANAPC7
AOPEP
ARHGAP32
ARVCF
AURKB
CA9
CASP3
CASP8
CBLL1
CCNB1
CDC42
CDK8
CHEK1
CSE1L
CSNK2A1
CTNNA1
CTNNB1
CTNND1
CTNND2
DNMT3A
EGFR
ERBIN
EZR
FADD
FARP2
FER
FGFR1
FYN
GALNT12
GNA12
GNA13
GSK3B
HDAC1
HDAC2
HEMGN
HRAS
HSD17B3
IQGAP1
IRS1
ITGAE
ITGB7
JUP
KEAP1
MAD2L2
MAP2K1
MAPK3
MKI67
MSANTD3
MYO6
NANS
NDRG1
NEDD9
NFE2L2
PIP5K1C
PKD1
PKP4
PPP1CA
PSEN1
PTPN14
PTPRF
PTPRM
PTTG1
RAB8B
RRM2
SFRP2
STX17
TMOD1
UCA1
UCHL3
VCL
YES1
ZNF510
Entrez ID
10672
999
HPRD ID
05100
01885
Ensembl ID
ENSG00000120063
ENSG00000039068
Uniprot IDs
Q14344
A0A0U2ZQU7
B3GN61
P12830
Q9UII7
PDB IDs
7SF7
7SF8
7T6B
7YDH
8H8J
8KGG
8ZX4
8ZX5
9GE2
9GE3
9IY8
9IZH
1O6S
2O72
2OMT
2OMU
2OMV
2OMX
2OMY
2OMZ
3FF7
3FF8
3L6X
3L6Y
4ZT1
4ZTE
6CXY
6OLE
6OLF
6OLG
6VEL
7STZ
8H62
Enriched GO Terms of Interacting Partners
?
G Protein-coupled Receptor Signaling Pathway
Signal Transduction
Plasma Membrane
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Membrane
G Protein-coupled Receptor Activity
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Cellular Response To Oxygen-containing Compound
Intracellular Signal Transduction
Rho-activating G Protein-coupled Receptor Signaling Pathway
Intracellular Signaling Cassette
G Protein-coupled Receptor Binding
Sphingosine-1-phosphate Receptor Activity
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Regulation Of Body Fluid Levels
Positive Regulation Of Vasculature Development
Peptidyl-serine Phosphorylation
Positive Regulation Of Signal Transduction
Modulation Of Chemical Synaptic Transmission
Guanyl-nucleotide Exchange Factor Activity
Sphingosine-1-phosphate Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Sphingolipid Mediated Signaling Pathway
Diacylglycerol-dependent Serine/threonine Kinase Activity
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Rho Protein Signal Transduction
Positive Regulation Of Cytosolic Calcium Ion Concentration
Response To Lipid
Cell Motility
Regulation Of Multicellular Organismal Process
Regulation Of Blood Pressure
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of MAPK Cascade
Catenin Complex
Cell Surface Receptor Signaling Pathway
Protein Kinase C Signaling
Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity
G-protein Alpha-subunit Binding
Cell Migration
Lamellipodium
Regulation Of Protein Localization
Regulation Of Vasculature Development
Regulation Of Developmental Process
Cellular Response To Indole-3-methanol
Cell-cell Adhesion
Adherens Junction
Cell Adhesion
Regulation Of Cell Motility
Regulation Of Cell Migration
Regulation Of Locomotion
Cell Surface Receptor Signaling Pathway
Cytoplasm
Focal Adhesion
Cadherin Binding
Regulation Of Intracellular Signal Transduction
Regulation Of Cellular Component Organization
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell-cell Junction
Regulation Of Signal Transduction
Intracellular Signal Transduction
Signal Transduction
Anchoring Junction
Regulation Of Signaling
Regulation Of Cell Communication
Plasma Membrane
Regulation Of Apoptotic Signaling Pathway
Regulation Of Cell Projection Organization
Regulation Of Mitotic Cell Cycle
Response To Xenobiotic Stimulus
Cell Cortex
Negative Regulation Of Apoptotic Signaling Pathway
Anatomical Structure Morphogenesis
Regulation Of Protein Catabolic Process
Regulation Of Cell Adhesion
Regulation Of Protein Metabolic Process
Positive Regulation Of Cell Migration
Cell Motility
Regulation Of Cell Population Proliferation
Positive Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Cell Cycle
Nucleus
Positive Regulation Of Cell Motility
Negative Regulation Of Cell Motility
Cytosol
Cytoskeleton
Positive Regulation Of Locomotion
ERBB Signaling Pathway
Cell Migration
Positive Regulation Of Signal Transduction
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Cellular Component Organization
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Tagcloud (Intersection)
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