GNA13 and RIC8A

Number of citations of the paper that reports this interaction (PubMedID 12509430)
0

Data Source:
HPRD (two hybrid, in vitro)

		GNA13	RIC8A
Description		G protein subunit alpha 13	RIC8 guanine nucleotide exchange factor A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Exosome Postsynapse	Cytoplasm Plasma Membrane Cell Cortex Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Folding Chaperone
	Biological Process	Angiogenesis Branching Involved In Blood Vessel Morphogenesis In Utero Embryonic Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Blood Pressure Regulation Of Cell Shape Regulation Of Fibroblast Migration Cell Differentiation Platelet Activation Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Assembly Rho-activating G Protein-coupled Receptor Signaling Pathway	In Utero Embryonic Development Vasculature Development Protein Folding G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gastrulation Visual Learning Response To Light Stimulus Cell Migration Involved In Gastrulation Cell-cell Adhesion Involved In Gastrulation Basement Membrane Organization
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Thromboxane signalling through TP receptor Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Periventricular white matter hyperintensities ( 32517579) White matter microstructure (global fractional anisotropy) ( 24736177)	Cataracts ( 34127677) Cataracts (operation) ( 31816047) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Mean corpuscular hemoglobin concentration ( 29403010) Meningioma ( 29762745) Platelet count ( 24026423) Uterine fibroids ( 21460842 31488892 31649266) Uterine fibroids (MTAG) ( 31488892)
Interacting Genes		31 interacting genes: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR	27 interacting genes: ATP1A4 EFEMP1 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS MAPK8IP3 MID1 NECAB2 NUTM1 OGT PACSIN2 PDE4B RABAC1 SDCBP SH3GLB1 SLC2A13 TERF1 TUBB2A UBQLN1 UBQLN4 XPO1 ZDHHC17 ZNF585B
Entrez ID		10672	60626
HPRD ID		05100	12373
Ensembl ID		ENSG00000120063	ENSG00000177963
Uniprot IDs		Q14344	Q9NPQ8
PDB IDs		7SF7 7SF8 7T6B 7YDH 8H8J 8KGG 8ZX4 8ZX5 9GE2 9GE3 9IY8 9IZH
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Membrane G Protein-coupled Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Oxygen-containing Compound Intracellular Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette G Protein-coupled Receptor Binding Sphingosine-1-phosphate Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Vasculature Development Peptidyl-serine Phosphorylation Positive Regulation Of Signal Transduction Modulation Of Chemical Synaptic Transmission Guanyl-nucleotide Exchange Factor Activity Sphingosine-1-phosphate Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Sphingolipid Mediated Signaling Pathway Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Lipid Cell Motility Regulation Of Multicellular Organismal Process Regulation Of Blood Pressure Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Catenin Complex Cell Surface Receptor Signaling Pathway Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity G-protein Alpha-subunit Binding Cell Migration Lamellipodium Regulation Of Protein Localization Regulation Of Vasculature Development Regulation Of Developmental Process Cellular Response To Indole-3-methanol	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase Regulator Activity GTPase Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway GTP Binding G Protein Activity G Protein-coupled Receptor Binding Mu-type Opioid Receptor Binding Cytoplasm Negative Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Cell Body Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Prostaglandin E Corticotropin-releasing Hormone Receptor 1 Binding Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Cellular Component Organization Cytoplasmic Vesicle Regulation Of Cell Communication Centriolar Satellite Regulation Of Protein Localization Regulation Of Signaling Plasma Membrane Regulation Of Transport Negative Regulation Of Cellular Component Organization Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Golgi Apparatus Regulation Of Establishment Of Protein Localization G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Endocytosis Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Midbody Identical Protein Binding Regulation Of Macroautophagy Regulation Of Relaxation Of Muscle Negative Regulation Of Receptor Internalization Regulation Of Proteasomal Protein Catabolic Process Extracellular Vesicle Cellular Response To Acidic PH Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of MAPK Cascade Cell Projection G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction
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