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MTNR1A and GNB1
Number of citations of the paper that reports this interaction (PMID
17215244
)
14
Data Source:
HPRD
(in vivo)
MTNR1A
GNB1
Gene Name
melatonin receptor 1A
guanine nucleotide binding protein (G protein), beta polypeptide 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Photoreceptor Inner Segment
Intracellular
Lysosomal Membrane
Heterotrimeric G-protein Complex
Plasma Membrane
Membrane
Dendrite
Vesicle
Photoreceptor Outer Segment Membrane
Cell Body
Extracellular Vesicular Exosome
Photoreceptor Disc Membrane
Molecular Function
Protein Binding
Melatonin Receptor Activity
Hormone Binding
Organic Cyclic Compound Binding
GTPase Activity
Signal Transducer Activity
Protein Binding
Spectrin Binding
Type 1 Angiotensin Receptor Binding
Protein Complex Binding
GTPase Binding
Biological Process
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Mating Behavior
Circadian Rhythm
Positive Regulation Of CGMP Biosynthetic Process
Energy Reserve Metabolic Process
Signal Transduction
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Ras Protein Signal Transduction
Synaptic Transmission
Blood Coagulation
Phototransduction, Visible Light
Cell Proliferation
Cardiac Muscle Cell Apoptotic Process
Rhodopsin Mediated Signaling Pathway
Regulation Of Rhodopsin Mediated Signaling Pathway
Platelet Activation
Small Molecule Metabolic Process
Sensory Perception Of Taste
Retina Development In Camera-type Eye
Cellular Response To Glucagon Stimulus
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Hypoxia
Cellular Response To Catecholamine Stimulus
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
GPCR downstream signaling
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
Signaling by GPCR
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 1
Integration of energy metabolism
G alpha (s) signalling events
Activation of GABAB receptors
Glucagon-type ligand receptors
G beta:gamma signalling through PLC beta
Signaling by Wnt
Metabolic disorders of biological oxidation enzymes
G protein gated Potassium channels
Olfactory Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
Thromboxane signalling through TP receptor
G alpha (z) signalling events
G alpha (i) signalling events
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
ADP signalling through P2Y purinoceptor 12
Glucagon signaling in metabolic regulation
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Inwardly rectifying K+ channels
G-protein beta:gamma signalling
Opioid Signalling
Activation of Kainate Receptors upon glutamate binding
Diseases associated with visual transduction
Aquaporin-mediated transport
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (q) signalling events
GPCR downstream signaling
Platelet homeostasis
Platelet activation, signaling and aggregation
Transmission across Chemical Synapses
G alpha (q) signalling events
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signal amplification
Potassium Channels
Activation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
G beta:gamma signalling through PI3Kgamma
The phototransduction cascade
G alpha (12/13) signalling events
Class B/2 (Secretin family receptors)
Prostacyclin signalling through prostacyclin receptor
GABA B receptor activation
GABA receptor activation
Activation of G protein gated Potassium channels
Vasopressin regulates renal water homeostasis via Aquaporins
Regulation of insulin secretion
GPCR ligand binding
beta-catenin independent WNT signaling
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Visual phototransduction
Ca2+ pathway
G-protein activation
Drugs
Ramelteon
Melatonin
Agomelatine
Diseases
GWAS
Obesity (
21552555
)
Protein-Protein Interactions
26 interactors:
CALR
CANX
CNP
DPM1
EEF1G
FLNA
GNA11
GNA13
GNAI1
GNAI2
GNAI3
GNB1
GNB4
GPR50
HNRNPA0
HSPA5
IRS4
LRRC59
MTNR1B
PDIA6
PGRMC1
RAB10
RAC1
RAP1A
TMEM33
VAPB
43 interactors:
ADRA2A
ADRB2
ADRBK1
AFP
ARHGEF18
ARRB1
ATXN10
AVPR2
CACNA1A
CACNA1B
CACNA1C
CYFIP1
DISC1
EPHA7
GNA12
GNAS
GNB2L1
GNG10
GNG11
GNG12
GNG13
GNG2
GNG3
GNG4
GNG5
GNG7
GNG8
GNGT1
HDAC4
HDAC5
KCNJ3
MCF2
MRGPRX1
MTNR1A
MTNR1B
NOL11
NR3C1
PDCL
PLEKHG2
PTH1R
RASD1
RASD2
TBXA2R
Entrez ID
4543
2782
HPRD ID
02812
00766
Ensembl ID
ENSG00000168412
ENSG00000078369
Uniprot IDs
P48039
P62873
PDB IDs
4KFM
Enriched GO Terms of Interacting Partners
?
Platelet Activation
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Blood Coagulation
Hemostasis
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Regulation Of Body Fluid Levels
Wound Healing
Cell Activation
Response To Wounding
Signaling
Cell Communication
Response To Stimulus
G-protein Coupled Receptor Signaling Pathway
Signal Transduction
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Response To Organic Substance
Positive Regulation Of Nuclease Activity
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Kinase Activity
Vesicle-mediated Transport
Positive Regulation Of Transferase Activity
Response To Stress
Synaptic Transmission
Cell-cell Signaling
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Unfolded Protein
ER-nucleus Signaling Pathway
Cellular Response To Stimulus
Cellular Response To Topologically Incorrect Protein
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Kinase Activity
Dopamine Receptor Signaling Pathway
Substantia Nigra Development
Cellular Response To Organic Substance
Response To Unfolded Protein
Regulation Of Kinase Activity
Membrane Organization
Positive Regulation Of Phosphorylation
Response To Endoplasmic Reticulum Stress
Cell Surface Receptor Signaling Pathway
Neural Nucleus Development
Positive Regulation Of Protein Modification Process
Ras Protein Signal Transduction
Regulation Of Protein Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Kinase Activity
Response To Peptide Hormone
Midbrain Development
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Response To Glucagon Stimulus
Signaling
Cell Communication
Energy Reserve Metabolic Process
G-protein Coupled Receptor Signaling Pathway
Response To Glucagon
Signal Transduction
Cell Surface Receptor Signaling Pathway
Energy Derivation By Oxidation Of Organic Compounds
Cellular Response To Stimulus
Response To Stimulus
Generation Of Precursor Metabolites And Energy
Cellular Response To Hormone Stimulus
Synaptic Transmission
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Response To Peptide
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Regulation Of Cellular Process
Response To Peptide Hormone
Cell-cell Signaling
Cellular Response To Organonitrogen Compound
Response To Hormone
Cellular Response To Organic Substance
Response To Organic Substance
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Response To Organonitrogen Compound
Regulation Of Signaling
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Regulation Of CAMP Metabolic Process
Regulation Of Adenylate Cyclase Activity
Regulation Of Signal Transduction
Regulation Of Cyclase Activity
Oxidation-reduction Process
Regulation Of Muscle Contraction
Positive Regulation Of Metabolic Process
Positive Regulation Of Cyclic Nucleotide Metabolic Process
Multicellular Organismal Response To Stress
Regulation Of CAMP Biosynthetic Process
Platelet Activation
Regulation Of Insulin Secretion
Chemical Homeostasis
Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway
Intracellular Signal Transduction
Regulation Of Peptide Hormone Secretion
Cellular Process
Adrenergic Receptor Signaling Pathway
Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway
Regulation Of Vasoconstriction
Small Molecule Metabolic Process
Tagcloud
?
abl
alterations
bcr
bez235
braf
canonical
cdkn2a
clustered
coexpression
confer
dimer
disrupt
effectors
encoding
galpha
gbeta
gbetagamma
gnb2
i80
interface
k57
neoplasms
oncogenic
partly
substitution
subunits
targetable
v600k
variants
Tagcloud (Difference)
?
abl
alterations
bcr
bez235
braf
canonical
cdkn2a
clustered
coexpression
confer
dimer
disrupt
effectors
encoding
galpha
gbeta
gbetagamma
gnb2
i80
interface
k57
neoplasms
oncogenic
partly
substitution
subunits
targetable
v600k
variants
Tagcloud (Intersection)
?