MTNR1A and GNAI3

Number of citations of the paper that reports this interaction (PMID 10598579)
21

Data Source:
HPRD (in vitro, in vivo)

		MTNR1A	GNAI3
Gene Name		melatonin receptor 1A	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Cytoplasm Lysosomal Membrane Golgi Apparatus Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Melatonin Receptor Activity Hormone Binding Organic Cyclic Compound Binding	GTPase Activity Signal Transducer Activity GTP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Mating Behavior Circadian Rhythm Positive Regulation Of CGMP Biosynthetic Process	Transport Vesicle Fusion Cell Cycle Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Synaptic Transmission Blood Coagulation Platelet Activation Cell Division
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway Signaling by GPCR PLC beta mediated events Activation of GABAB receptors G alpha (s) signalling events Opioid Signalling Signal amplification G-protein mediated events Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Transmission across Chemical Synapses
Drugs		Ramelteon Melatonin Agomelatine
Diseases
GWAS		Obesity ( 21552555)	Major depressive disorder ( 20125088)
Protein-Protein Interactions		26 interactors: CALR CANX CNP DPM1 EEF1G FLNA GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 HNRNPA0 HSPA5 IRS4 LRRC59 MTNR1B PDIA6 PGRMC1 RAB10 RAC1 RAP1A TMEM33 VAPB	40 interactors: AGTR2 ATP12A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 ESR1 GNB2 GNB4 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR
Entrez ID		4543	2773
HPRD ID		02812	00765
Ensembl ID		ENSG00000168412
Uniprot IDs		P48039	P08754 Q5TZX1
PDB IDs			2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?		Platelet Activation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Signaling Cell Communication Response To Stimulus G-protein Coupled Receptor Signaling Pathway Signal Transduction Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Organic Substance Positive Regulation Of Nuclease Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Kinase Activity Vesicle-mediated Transport Positive Regulation Of Transferase Activity Response To Stress Synaptic Transmission Cell-cell Signaling Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Stimulus Cellular Response To Topologically Incorrect Protein Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Dopamine Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Organic Substance Response To Unfolded Protein Regulation Of Kinase Activity Membrane Organization Positive Regulation Of Phosphorylation Response To Endoplasmic Reticulum Stress Cell Surface Receptor Signaling Pathway Neural Nucleus Development Positive Regulation Of Protein Modification Process Ras Protein Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Response To Peptide Hormone Midbrain Development G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Regulation Of Signaling G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Response To Stimulus Cellular Response To Stimulus Regulation Of Cellular Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Chemical Homeostasis Regulation Of Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Behavior Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Single-organism Behavior Metal Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Homeostatic Process Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Dopamine Secretion Blood Circulation Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Regulation Of Nitric-oxide Synthase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Cell Proliferation Regulation Of Hormone Secretion
Tagcloud ?			akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested
Tagcloud (Difference) ?			akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested
Tagcloud (Intersection) ?