GNA13 and S1PR3

Number of citations of the paper that reports this interaction (PMID 10488065)
54

Data Source:
HPRD (in vitro)

		GNA13	S1PR3
Gene Name		guanine nucleotide binding protein (G protein), alpha 13	sphingosine-1-phosphate receptor 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 1 Angiotensin Receptor Binding D5 Dopamine Receptor Binding Metal Ion Binding	G-protein Coupled Receptor Activity Integrin Binding Lipid Binding Sphingosine-1-phosphate Receptor Activity
	Biological Process	Patterning Of Blood Vessels In Utero Embryonic Development Movement Of Cell Or Subcellular Component Signal Transduction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Blood Coagulation Regulation Of Cell Shape Cell Differentiation Platelet Activation Regulation Of Cell Migration Activation Of Phospholipase D Activity	Cytokine Production Sphingosine-1-phosphate Signaling Pathway Inflammatory Response G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Regulation Of Interleukin-1 Beta Production Negative Regulation Of Establishment Of Endothelial Barrier
Pathways		Thrombin signalling through proteinase activated receptors (PARs) Signaling by GPCR GPCR downstream signaling Thromboxane signalling through TP receptor G alpha (12/13) signalling events Signal amplification Platelet activation, signaling and aggregation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS			Response to statin therapy (LDL-C) ( 22331829)
Protein-Protein Interactions		31 interactors: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR	4 interactors: GNA13 GNAI1 GNAQ HTR1A
Entrez ID		10672	1903
HPRD ID		05100	03572
Ensembl ID		ENSG00000120063	ENSG00000213694
Uniprot IDs		B7Z7R0 F5H1G8 Q14344	Q99500
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Catalytic Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Signaling Regulation Of Signaling Cell Communication Regulation Of Catalytic Activity Regulation Of Signal Transduction Cellular Response To Stimulus Cytosolic Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Activation Cellular Chemical Homeostasis Ion Homeostasis Apoptotic Process Programmed Cell Death Response To Stimulus Positive Regulation Of Hydrolase Activity Cellular Response To Organic Substance Cell Death Death Chemical Homeostasis Cellular Homeostasis Regulation Of Cellular Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Intracellular Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Platelet Activation Homeostatic Process Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Cellular Metabolic Process Termination Of Signal Transduction	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Phospholipase Activity Wound Healing Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Cell Activation Response To Wounding Cell Surface Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Response To Stress Regulation Of Serotonin Secretion Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Regulation Of Melanocyte Differentiation Serotonin Metabolic Process Serotonin Receptor Signaling Pathway Signal Transduction Activation Of Phospholipase D Activity Maternal Behavior Regulation Of Dopamine Metabolic Process Signaling Cell Communication Behavior Regulation Of Catenin Import Into Nucleus Regulation Of Developmental Pigmentation Exploration Behavior Neuron Maturation Vasoconstriction Dopamine Receptor Signaling Pathway Behavioral Fear Response Cellular Response To Stimulus Forebrain Neuron Development Fear Response Cardiovascular System Development Patterning Of Blood Vessels Activation Of Phospholipase C Activity Vesicle Fusion Positive Regulation Of Phospholipase C Activity Rho Protein Signal Transduction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway
Tagcloud ?		18q 19p13 1q aberrations arising burkitt collaborating cooperate copy deep enhancer gains id3 immunoglobulin lymphoma microrna myc next profiling recurrent scope sequencing signatures smarca4 subgroups summary transcriptome widened yielded	acetyl albumin alleviates ao bsa circulation equivalent excretion fty720 glucosaminidase gradually immunomodulatory infiltration ip killed mcp monocytes nephrectomy nephropathy overload reached s1pr1 saline sphingosine sphk1 synthesizing tubulointerstitium wistar
Tagcloud (Difference) ?		18q 19p13 1q aberrations arising burkitt collaborating cooperate copy deep enhancer gains id3 immunoglobulin lymphoma microrna myc next profiling recurrent scope sequencing signatures smarca4 subgroups summary transcriptome widened yielded	acetyl albumin alleviates ao bsa circulation equivalent excretion fty720 glucosaminidase gradually immunomodulatory infiltration ip killed mcp monocytes nephrectomy nephropathy overload reached s1pr1 saline sphingosine sphk1 synthesizing tubulointerstitium wistar
Tagcloud (Intersection) ?