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MTNR1A and HSPA5
Number of citations of the paper that reports this interaction (PMID
17215244
)
14
Data Source:
HPRD
(in vivo)
MTNR1A
HSPA5
Gene Name
melatonin receptor 1A
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Nucleus
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Plasma Membrane
Focal Adhesion
COP9 Signalosome
Cell Surface
Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Midbody
Endoplasmic Reticulum Chaperone Complex
Melanosome
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Melatonin Receptor Activity
Hormone Binding
Organic Cyclic Compound Binding
Glycoprotein Binding
Calcium Ion Binding
Protein Binding
ATP Binding
ATPase Activity
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Ribosome Binding
Unfolded Protein Binding
Chaperone Binding
Misfolded Protein Binding
Biological Process
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Mating Behavior
Circadian Rhythm
Positive Regulation Of CGMP Biosynthetic Process
Platelet Degranulation
ER Overload Response
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Blood Coagulation
Cerebellum Structural Organization
Cerebellar Purkinje Cell Layer Development
Substantia Nigra Development
Platelet Activation
Positive Regulation Of Cell Migration
ER-associated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Protein Ubiquitination
Maintenance Of Protein Localization In Endoplasmic Reticulum
Cellular Response To Glucose Starvation
Negative Regulation Of Apoptotic Process
Cellular Protein Metabolic Process
Regulation Of Protein Folding In Endoplasmic Reticulum
Cellular Response To Antibiotic
Cellular Response To Interleukin-4
Toxin Transport
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
GPCR downstream signaling
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
Platelet degranulation
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
ATF6-alpha activates chaperone genes
IRE1alpha activates chaperones
Response to elevated platelet cytosolic Ca2+
Class I MHC mediated antigen processing & presentation
Platelet activation, signaling and aggregation
ATF6-alpha activates chaperones
PERK regulates gene expression
Unfolded Protein Response (UPR)
Adaptive Immune System
Drugs
Ramelteon
Melatonin
Agomelatine
Antihemophilic Factor
Diseases
GWAS
Obesity (
21552555
)
Protein-Protein Interactions
26 interactors:
CALR
CANX
CNP
DPM1
EEF1G
FLNA
GNA11
GNA13
GNAI1
GNAI2
GNAI3
GNB1
GNB4
GPR50
HNRNPA0
HSPA5
IRS4
LRRC59
MTNR1B
PDIA6
PGRMC1
RAB10
RAC1
RAP1A
TMEM33
VAPB
53 interactors:
A2M
APC
APOB
BCAR1
CASP7
CPT1A
DDX24
DNAJC1
DNAJC10
DPH1
DPYSL5
EIF2AK3
ERN1
ERP29
F8
FCHSD2
GRB2
GRIA1
HLA-C
HSPBP1
HTR3A
ID2
IGHM
KRT14
KRT18
KRT8
LCT
LDLR
METTL21A
MTNR1A
MTNR1B
NDRG1
PAWR
PCSK7
PRNP
PSME3
RPN1
SEC61A1
SH3BP4
SIL1
SREBF2
STMN1
SUMO4
TCERG1
TG
TMEM132A
TMEM62
TRA
TSHR
UBQLN4
VHL
VWF
YWHAB
Entrez ID
4543
3309
HPRD ID
02812
00682
Ensembl ID
ENSG00000168412
ENSG00000044574
Uniprot IDs
P48039
P11021
PDB IDs
3IUC
3LDL
3LDN
3LDO
3LDP
Enriched GO Terms of Interacting Partners
?
Platelet Activation
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Blood Coagulation
Hemostasis
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Regulation Of Body Fluid Levels
Wound Healing
Cell Activation
Response To Wounding
Signaling
Cell Communication
Response To Stimulus
G-protein Coupled Receptor Signaling Pathway
Signal Transduction
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Response To Organic Substance
Positive Regulation Of Nuclease Activity
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Kinase Activity
Vesicle-mediated Transport
Positive Regulation Of Transferase Activity
Response To Stress
Synaptic Transmission
Cell-cell Signaling
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Unfolded Protein
ER-nucleus Signaling Pathway
Cellular Response To Stimulus
Cellular Response To Topologically Incorrect Protein
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Kinase Activity
Dopamine Receptor Signaling Pathway
Substantia Nigra Development
Cellular Response To Organic Substance
Response To Unfolded Protein
Regulation Of Kinase Activity
Membrane Organization
Positive Regulation Of Phosphorylation
Response To Endoplasmic Reticulum Stress
Cell Surface Receptor Signaling Pathway
Neural Nucleus Development
Positive Regulation Of Protein Modification Process
Ras Protein Signal Transduction
Regulation Of Protein Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Kinase Activity
Response To Peptide Hormone
Midbrain Development
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Response To Stimulus
Cellular Response To Stimulus
Apoptotic Signaling Pathway
Response To Stress
Blood Coagulation, Intrinsic Pathway
Cell Activation
Signal Transduction
Apoptotic Process
Positive Regulation Of Metabolic Process
Programmed Cell Death
Signaling
Positive Regulation Of Cellular Metabolic Process
Intrinsic Apoptotic Signaling Pathway
Cell Death
Death
Cell Communication
Platelet Activation
Regulation Of Proteolysis
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Body Fluid Levels
Negative Regulation Of Cellular Protein Metabolic Process
Blood Coagulation
Negative Regulation Of Cellular Metabolic Process
Protein Oligomerization
Hemostasis
Response To External Stimulus
Cellular Response To Organic Substance
Protein Folding
Regulation Of Lipid Metabolic Process
Response To Organic Substance
Response To Inorganic Substance
Negative Regulation Of Protein Metabolic Process
Platelet Degranulation
Lipoprotein Catabolic Process
Regulation Of Apoptotic Process
Regulation Of Cholesterol Homeostasis
Hepatocyte Apoptotic Process
Protein Metabolic Process
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Cholesterol Storage
Negative Regulation Of T Cell Receptor Signaling Pathway
Axonogenesis
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Viral Process
Cellular Response To Stress
Cell Development
Anatomical Structure Morphogenesis
Tagcloud
?
17q
22cm
canine
centromeric
cfa9
correspond
cosmid
cryba1
distal
dog
grp78
hsa17
hsa17q
hsa9q
hsa9q34
lies
linkage
loci
map
mmu2
nf1
occupy
painting
places
probable
rxra
syntenic
telomeric
thirds
Tagcloud (Difference)
?
17q
22cm
canine
centromeric
cfa9
correspond
cosmid
cryba1
distal
dog
grp78
hsa17
hsa17q
hsa9q
hsa9q34
lies
linkage
loci
map
mmu2
nf1
occupy
painting
places
probable
rxra
syntenic
telomeric
thirds
Tagcloud (Intersection)
?