MTNR1A and COL9A2

Number of citations of the paper that reports this interaction (PubMedID 26514267)
0

Data Source:
BioGRID (two hybrid)

		MTNR1A	COL9A2
Description		melatonin receptor 1A	collagen type IX alpha 2 chain
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GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Extracellular Region Collagen Trimer Collagen Type IX Trimer Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity Hormone Binding	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein Homodimerization Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mating Behavior Circadian Rhythm	Skeletal System Development
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs		Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
Diseases			Multiple epiphyseal dysplasia (MED)
GWAS		Depressive symptoms measurement (somatic complaints domain) ( 26997408) Job-related exhaustion in shift workers ( 28364478) Mild obesity-related type 2 diabetes ( 34737425) Obesity ( 21552555)	Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		160 interacting genes: ABHD14B ACTB ACTN1 AMOTL2 ANKRD12 ARHGAP28 ASAP3 ASCL1 ATIC ATP5MC3 BAG6 BAZ1A BAZ1B C10orf90 CALR CAND1 CANX CCDC167 CD99 CHD4 CIAO2B CIT CLASP1 CMIP CNP COG1 COL9A2 COMT COX11 CTNNA1 CTPS2 CUL3 CUL7 CYP27C1 CYSRT1 DDHD2 DDX52 DPM1 ECE1 ECE2 EEF1G EMC7 EMD ENO2 EPS15 EXOC1 F8A1 FAM241B FDXR FLNA FN1 FSTL1 GALNS GAPDH GATAD2B GBA2 GEMIN2 GFPT2 GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 H2AC6 HDAC10 HIVEP2 HMGN2 HMOX2 HNRNPA0 HNRNPH1 HSPA5 IPO9 IRS4 ITPR3 KLHL12 KLHL20 KLHL5 KPNB1 KRTAP1-3 KRTAP10-8 LAPTM4A LIPE LPP LRP3 LRRC59 MAMLD1 MCC MESD MMP2 MMS19 MPDZ MTNR1B MYO9A NAP1L1 NAP1L4 NAP1L5 NASP PAXIP1 PCDHB10 PDIA6 PEX14 PGRMC1 PKD1L2 PPP2R3C PRELID1 PSMD2 PSME4 PTPN13 PTPRD PTX3 RAB10 RAC1 RACK1 RAP1A RBM39 RGS12 RNF2 RNF41 RPL3 RTRAF SLC2A3 SLC30A1 SLC6A3 SLIT1 SNAPIN SOX11 SRI STXBP1 SUCLA2 SURF4 SVEP1 TLN1 TM9SF1 TMEM14A TMEM230 TMEM33 TMX2 TPP2 TRIP12 TUBB TVP23B UBA1 UBAP2L UBQLN1 UBR4 USP28 USP32 USP34 VAPB VARS1 WAPL WASHC4 YWHAB YWHAZ ZC3H11A ZDHHC16 ZNF460	10 interacting genes: COL2A1 ERBB2 FEZ1 HAP1 MAG MEOX2 MTNR1A NOA1 UBQLN1 UBQLN2
Entrez ID		4543	1298
HPRD ID		02812	00373
Ensembl ID		ENSG00000168412	ENSG00000049089
Uniprot IDs		P48039	Q14055
PDB IDs		6ME2 6ME3 6ME4 6ME5 7DB6 7VGY 7VGZ	5CTD 5CTI 5CVA 5CVB
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Cytosol Heterotrimeric G-protein Complex Focal Adhesion Melanosome Guanyl Nucleotide Binding Membrane G-protein Beta/gamma-subunit Complex Binding Cadherin Binding Homotypic Cell-cell Adhesion Regulation Of Organelle Organization Proteasomal Protein Catabolic Process G Protein Activity Regulation Of Cellular Component Organization Cytoplasm G Protein-coupled Receptor Binding Platelet Aggregation Diacylglycerol Lipase Activity Protein Binding Vinculin Binding Cellular Localization Protein Folding In Endoplasmic Reticulum Regulation Of Biological Quality Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process GTPase Activity Negative Regulation Of Vasoconstriction Proteolysis Neural Nucleus Development Establishment Of Protein Localization Protein Metabolic Process Negative Regulation Of Synapse Organization Cullin-RING Ubiquitin Ligase Complex Nucleoplasm Nucleosomal DNA Binding Protein-containing Complex Binding Melatonin Receptor Activity	Regulation Of Organelle Transport Along Microtubule Autophagosome Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Cellular Response To Growth Factor Stimulus Regulation Of Microtubule-based Process Myelin Sheath Regulation Of Microtubule-based Movement Autophagy Positive Regulation Of Neurotrophin Production Regulation Of Organelle Assembly Mitochondrion Localization Regulation Of Autophagosome Assembly Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Regulation Of Vacuole Organization Regulation Of Macroautophagy Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Store-operated Calcium Channel Activity Response To Growth Factor Roof Of Mouth Development Signaling Receptor Binding ERBB3:ERBB2 Complex Cytoplasmic Vesicle Myelination Axon Ensheathment Mesaxon Regulation Of Transmembrane Transporter Activity Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Autophagy Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of G Protein-coupled Receptor Internalization Collagen Type II Trimer RNA Polymerase I Core Binding Ganglioside GT1b Binding Brain-derived Neurotrophic Factor Binding Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Autophagosome Organization Negative Regulation Of Toll-like Receptor 3 Signaling Pathway System Development Positive Regulation Of Proteasomal Protein Catabolic Process Collagen Type XI Trimer Anterior Head Development Negative Regulation Of Immature T Cell Proliferation In Thymus Neuron Projection Development ErbB-3 Class Receptor Binding Regulation Of Cellular Localization
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