MTNR1A and RPL3

Number of citations of the paper that reports this interaction (PubMedID 26514267)
0

Data Source:
BioGRID (two hybrid)

		MTNR1A	RPL3
Description		melatonin receptor 1A	ribosomal protein L3
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Nucleus Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Protein-containing Complex Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity Hormone Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mating Behavior Circadian Rhythm	Cytoplasmic Translation Translation Cellular Response To Interleukin-4
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon	(S)-3-phenyllactic acid Omacetaxine mepesuccinate Anisomycin Puromycin Xanthinol
Diseases
GWAS		Depressive symptoms measurement (somatic complaints domain) ( 26997408) Job-related exhaustion in shift workers ( 28364478) Mild obesity-related type 2 diabetes ( 34737425) Obesity ( 21552555)	Crohn's disease ( 28067908) Factor VIII levels ( 30586737) Inflammatory bowel disease ( 28067908) Primary biliary cholangitis ( 28425483) Primary biliary cirrhosis ( 22961000) Ulcerative colitis ( 28067908) vWF levels ( 30586737)
Interacting Genes		160 interacting genes: ABHD14B ACTB ACTN1 AMOTL2 ANKRD12 ARHGAP28 ASAP3 ASCL1 ATIC ATP5MC3 BAG6 BAZ1A BAZ1B C10orf90 CALR CAND1 CANX CCDC167 CD99 CHD4 CIAO2B CIT CLASP1 CMIP CNP COG1 COL9A2 COMT COX11 CTNNA1 CTPS2 CUL3 CUL7 CYP27C1 CYSRT1 DDHD2 DDX52 DPM1 ECE1 ECE2 EEF1G EMC7 EMD ENO2 EPS15 EXOC1 F8A1 FAM241B FDXR FLNA FN1 FSTL1 GALNS GAPDH GATAD2B GBA2 GEMIN2 GFPT2 GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 H2AC6 HDAC10 HIVEP2 HMGN2 HMOX2 HNRNPA0 HNRNPH1 HSPA5 IPO9 IRS4 ITPR3 KLHL12 KLHL20 KLHL5 KPNB1 KRTAP1-3 KRTAP10-8 LAPTM4A LIPE LPP LRP3 LRRC59 MAMLD1 MCC MESD MMP2 MMS19 MPDZ MTNR1B MYO9A NAP1L1 NAP1L4 NAP1L5 NASP PAXIP1 PCDHB10 PDIA6 PEX14 PGRMC1 PKD1L2 PPP2R3C PRELID1 PSMD2 PSME4 PTPN13 PTPRD PTX3 RAB10 RAC1 RACK1 RAP1A RBM39 RGS12 RNF2 RNF41 RPL3 RTRAF SLC2A3 SLC30A1 SLC6A3 SLIT1 SNAPIN SOX11 SRI STXBP1 SUCLA2 SURF4 SVEP1 TLN1 TM9SF1 TMEM14A TMEM230 TMEM33 TMX2 TPP2 TRIP12 TUBB TVP23B UBA1 UBAP2L UBQLN1 UBR4 USP28 USP32 USP34 VAPB VARS1 WAPL WASHC4 YWHAB YWHAZ ZC3H11A ZDHHC16 ZNF460	13 interacting genes: CREBBP DUX4 EXOSC8 ISG15 MTNR1A NDRG1 NUMB OGT RBFOX2 SIK1 STXBP3 SUMO2 TRAF6
Entrez ID		4543	6122
HPRD ID		02812	16042
Ensembl ID		ENSG00000168412	ENSG00000100316
Uniprot IDs		P48039	B3KS36 P39023 Q96QL0
PDB IDs		6ME2 6ME3 6ME4 6ME5 7DB6 7VGY 7VGZ	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Cytosol Heterotrimeric G-protein Complex Focal Adhesion Melanosome Guanyl Nucleotide Binding Membrane G-protein Beta/gamma-subunit Complex Binding Cadherin Binding Homotypic Cell-cell Adhesion Regulation Of Organelle Organization Proteasomal Protein Catabolic Process G Protein Activity Regulation Of Cellular Component Organization Cytoplasm G Protein-coupled Receptor Binding Platelet Aggregation Diacylglycerol Lipase Activity Protein Binding Vinculin Binding Cellular Localization Protein Folding In Endoplasmic Reticulum Regulation Of Biological Quality Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process GTPase Activity Negative Regulation Of Vasoconstriction Proteolysis Neural Nucleus Development Establishment Of Protein Localization Protein Metabolic Process Negative Regulation Of Synapse Organization Cullin-RING Ubiquitin Ligase Complex Nucleoplasm Nucleosomal DNA Binding Protein-containing Complex Binding Melatonin Receptor Activity	Rhythmic Process Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Protein Tag Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Histone Acetyltransferase Complex Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Membrane Regulation Of Protein Ubiquitination Protein Modification Process Glutamatergic Synapse Regulation Of Post-translational Protein Modification Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Gluconeogenesis Canonical NF-kappaB Signal Transduction Histone H3K18 Acetyltransferase Activity Chromatin DNA Binding Cytoplasm Negative Regulation Of DNA-templated Transcription N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Regulation Of Gene Expression Histone H3K27 Acetyltransferase Activity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Peptide Lactyltransferase (CoA-dependent) Activity Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Intracellular Glucose Homeostasis Tertiary Granule Positive Regulation Of Type I Interferon Production Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Protein Ubiquitination Protein O-acetylglucosaminyltransferase Activity Neuroblast Division In Subventricular Zone U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Regulation Of Macromolecule Biosynthetic Process Regulation Of Glucose Metabolic Process Post-translational Protein Modification Negative Regulation Of RNA Metabolic Process Melatonin Receptor Activity Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Oligomerization Negative Regulation Of CREB Transcription Factor Activity
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