MTNR1A and GNB4

Number of citations of the paper that reports this interaction (PubMedID 26514267)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vivo)

		MTNR1A	GNB4
Description		melatonin receptor 1A	G protein subunit beta 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Synapse Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity Hormone Binding	Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mating Behavior Circadian Rhythm	Signal Transduction G Protein-coupled Receptor Signaling Pathway Substantia Nigra Development
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
Diseases
GWAS		Depressive symptoms measurement (somatic complaints domain) ( 26997408) Job-related exhaustion in shift workers ( 28364478) Mild obesity-related type 2 diabetes ( 34737425) Obesity ( 21552555)	Atrial fibrillation ( 29892015 30061737) Heart rate ( 23583979) Resting heart rate ( 27798624 29769521)
Interacting Genes		160 interacting genes: ABHD14B ACTB ACTN1 AMOTL2 ANKRD12 ARHGAP28 ASAP3 ASCL1 ATIC ATP5MC3 BAG6 BAZ1A BAZ1B C10orf90 CALR CAND1 CANX CCDC167 CD99 CHD4 CIAO2B CIT CLASP1 CMIP CNP COG1 COL9A2 COMT COX11 CTNNA1 CTPS2 CUL3 CUL7 CYP27C1 CYSRT1 DDHD2 DDX52 DPM1 ECE1 ECE2 EEF1G EMC7 EMD ENO2 EPS15 EXOC1 F8A1 FAM241B FDXR FLNA FN1 FSTL1 GALNS GAPDH GATAD2B GBA2 GEMIN2 GFPT2 GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 H2AC6 HDAC10 HIVEP2 HMGN2 HMOX2 HNRNPA0 HNRNPH1 HSPA5 IPO9 IRS4 ITPR3 KLHL12 KLHL20 KLHL5 KPNB1 KRTAP1-3 KRTAP10-8 LAPTM4A LIPE LPP LRP3 LRRC59 MAMLD1 MCC MESD MMP2 MMS19 MPDZ MTNR1B MYO9A NAP1L1 NAP1L4 NAP1L5 NASP PAXIP1 PCDHB10 PDIA6 PEX14 PGRMC1 PKD1L2 PPP2R3C PRELID1 PSMD2 PSME4 PTPN13 PTPRD PTX3 RAB10 RAC1 RACK1 RAP1A RBM39 RGS12 RNF2 RNF41 RPL3 RTRAF SLC2A3 SLC30A1 SLC6A3 SLIT1 SNAPIN SOX11 SRI STXBP1 SUCLA2 SURF4 SVEP1 TLN1 TM9SF1 TMEM14A TMEM230 TMEM33 TMX2 TPP2 TRIP12 TUBB TVP23B UBA1 UBAP2L UBQLN1 UBR4 USP28 USP32 USP34 VAPB VARS1 WAPL WASHC4 YWHAB YWHAZ ZC3H11A ZDHHC16 ZNF460	18 interacting genes: GNAI1 GNAI2 GNAI3 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 GNGT2 MTNR1A MTNR1B PTEN UBC
Entrez ID		4543	59345
HPRD ID		02812	09973
Ensembl ID		ENSG00000168412	ENSG00000114450
Uniprot IDs		P48039	Q9HAV0
PDB IDs		6ME2 6ME3 6ME4 6ME5 7DB6 7VGY 7VGZ
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Cytosol Heterotrimeric G-protein Complex Focal Adhesion Melanosome Guanyl Nucleotide Binding Membrane G-protein Beta/gamma-subunit Complex Binding Cadherin Binding Homotypic Cell-cell Adhesion Regulation Of Organelle Organization Proteasomal Protein Catabolic Process G Protein Activity Regulation Of Cellular Component Organization Cytoplasm G Protein-coupled Receptor Binding Platelet Aggregation Diacylglycerol Lipase Activity Protein Binding Vinculin Binding Cellular Localization Protein Folding In Endoplasmic Reticulum Regulation Of Biological Quality Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process GTPase Activity Negative Regulation Of Vasoconstriction Proteolysis Neural Nucleus Development Establishment Of Protein Localization Protein Metabolic Process Negative Regulation Of Synapse Organization Cullin-RING Ubiquitin Ligase Complex Nucleoplasm Nucleosomal DNA Binding Protein-containing Complex Binding Melatonin Receptor Activity	Heterotrimeric G-protein Complex G-protein Beta-subunit Binding G Protein-coupled Receptor Signaling Pathway GTPase Activity Plasma Membrane Signal Transduction Guanyl Nucleotide Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Membrane Synapse Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Melatonin Receptor Activity Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Receptor Binding PDZ Domain Binding Extracellular Exosome Response To Prostaglandin E Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion By Cell Regulation Of G Protein-coupled Receptor Signaling Pathway Reproductive Behavior Negative Regulation Of Secretion Phototransduction Negative Regulation Of Insulin Secretion Midbody Negative Regulation Of Transport Negative Regulation Of Peptide Secretion Negative Regulation Of Synaptic Vesicle Clustering G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Detection Of Light Stimulus Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of Hormone Secretion Multicellular Organismal Response To Stress Negative Regulation Of Protein Secretion Regulation Of Vascular Associated Smooth Muscle Cell Proliferation D2 Dopamine Receptor Binding GDP Binding Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Cell Body Ciliary Basal Body Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep
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