MTNR1A and SOX11

Number of citations of the paper that reports this interaction (PubMedID 26514267)
0

Data Source:
BioGRID (two hybrid)

		MTNR1A	SOX11
Description		melatonin receptor 1A	SRY-box transcription factor 11
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GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Chromatin Nucleus Nucleoplasm Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity Hormone Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mating Behavior Circadian Rhythm	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Lens Morphogenesis In Camera-type Eye Outflow Tract Morphogenesis Noradrenergic Neuron Differentiation Nervous System Development Brain Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Oligodendrocyte Development Glial Cell Proliferation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Spinal Cord Development Glial Cell Development Cell Differentiation Neuron Differentiation Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Hippo Signaling Skeletal Muscle Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Secretion Sympathetic Nervous System Development Embryonic Digestive Tract Morphogenesis Camera-type Eye Morphogenesis Embryonic Skeletal System Morphogenesis Negative Regulation Of Lymphocyte Proliferation Positive Regulation Of Neurogenesis Hard Palate Development Soft Palate Development Negative Regulation Of Glial Cell Proliferation Ventricular Septum Morphogenesis Lung Morphogenesis Neuroepithelial Cell Differentiation Eyelid Development In Camera-type Eye Cornea Development In Camera-type Eye Closure Of Optic Fissure Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Lens Epithelial Cell Proliferation
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs		Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon
Diseases
GWAS		Depressive symptoms measurement (somatic complaints domain) ( 26997408) Job-related exhaustion in shift workers ( 28364478) Mild obesity-related type 2 diabetes ( 34737425) Obesity ( 21552555)	Age at first birth ( 34211149) Automobile speeding propensity ( 30643258) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronic kidney disease ( 20383146) Crohn's disease ( 23266558) Diabetic kidney disease ( 26305897) Hip circumference ( 25673412) Intraocular pressure ( 29617998) Multisite chronic pain ( 33830993) Obesity in adult survivors of childhood cancer exposed to cranial radiation ( 25963547) Obesity-related traits ( 23251661) Proteinuria and chronic kidney disease ( 26420894) Tuberculosis ( 24057671) Type 2 diabetes ( 31118516)
Interacting Genes		160 interacting genes: ABHD14B ACTB ACTN1 AMOTL2 ANKRD12 ARHGAP28 ASAP3 ASCL1 ATIC ATP5MC3 BAG6 BAZ1A BAZ1B C10orf90 CALR CAND1 CANX CCDC167 CD99 CHD4 CIAO2B CIT CLASP1 CMIP CNP COG1 COL9A2 COMT COX11 CTNNA1 CTPS2 CUL3 CUL7 CYP27C1 CYSRT1 DDHD2 DDX52 DPM1 ECE1 ECE2 EEF1G EMC7 EMD ENO2 EPS15 EXOC1 F8A1 FAM241B FDXR FLNA FN1 FSTL1 GALNS GAPDH GATAD2B GBA2 GEMIN2 GFPT2 GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 H2AC6 HDAC10 HIVEP2 HMGN2 HMOX2 HNRNPA0 HNRNPH1 HSPA5 IPO9 IRS4 ITPR3 KLHL12 KLHL20 KLHL5 KPNB1 KRTAP1-3 KRTAP10-8 LAPTM4A LIPE LPP LRP3 LRRC59 MAMLD1 MCC MESD MMP2 MMS19 MPDZ MTNR1B MYO9A NAP1L1 NAP1L4 NAP1L5 NASP PAXIP1 PCDHB10 PDIA6 PEX14 PGRMC1 PKD1L2 PPP2R3C PRELID1 PSMD2 PSME4 PTPN13 PTPRD PTX3 RAB10 RAC1 RACK1 RAP1A RBM39 RGS12 RNF2 RNF41 RPL3 RTRAF SLC2A3 SLC30A1 SLC6A3 SLIT1 SNAPIN SOX11 SRI STXBP1 SUCLA2 SURF4 SVEP1 TLN1 TM9SF1 TMEM14A TMEM230 TMEM33 TMX2 TPP2 TRIP12 TUBB TVP23B UBA1 UBAP2L UBQLN1 UBR4 USP28 USP32 USP34 VAPB VARS1 WAPL WASHC4 YWHAB YWHAZ ZC3H11A ZDHHC16 ZNF460	3 interacting genes: MTNR1A POU3F2 POU3F3
Entrez ID		4543	6664
HPRD ID		02812	02940
Ensembl ID		ENSG00000168412	ENSG00000176887
Uniprot IDs		P48039	P35716
PDB IDs		6ME2 6ME3 6ME4 6ME5 7DB6 7VGY 7VGZ	6T78 6T7A 6T7C 6T7D
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Cytosol Heterotrimeric G-protein Complex Focal Adhesion Melanosome Guanyl Nucleotide Binding Membrane G-protein Beta/gamma-subunit Complex Binding Cadherin Binding Homotypic Cell-cell Adhesion Regulation Of Organelle Organization Proteasomal Protein Catabolic Process G Protein Activity Regulation Of Cellular Component Organization Cytoplasm G Protein-coupled Receptor Binding Platelet Aggregation Diacylglycerol Lipase Activity Protein Binding Vinculin Binding Cellular Localization Protein Folding In Endoplasmic Reticulum Regulation Of Biological Quality Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process GTPase Activity Negative Regulation Of Vasoconstriction Proteolysis Neural Nucleus Development Establishment Of Protein Localization Protein Metabolic Process Negative Regulation Of Synapse Organization Cullin-RING Ubiquitin Ligase Complex Nucleoplasm Nucleosomal DNA Binding Protein-containing Complex Binding Melatonin Receptor Activity	Forebrain Ventricular Zone Progenitor Cell Division Cerebral Cortex Radially Oriented Cell Migration Cerebral Cortex Cell Migration Telencephalon Cell Migration Forebrain Cell Migration Metanephric DCT Cell Differentiation Metanephric Macula Densa Development Neurohypophysis Development Metanephric Thick Ascending Limb Development Metanephric Loop Of Henle Development Forebrain Astrocyte Development Brain Development Melatonin Receptor Activity Metanephric Ascending Thin Limb Development Hypothalamus Cell Differentiation Loop Of Henle Development Urea Transmembrane Transport Sequence-specific DNA Binding Cell Division HMG Box Domain Binding Metanephric Nephron Tubule Development Urea Transport Metanephric Tubule Development Metanephric Epithelium Development Hormone Binding Neuroendocrine Cell Differentiation Astrocyte Development Schwann Cell Development Nervous System Development Myelination In Peripheral Nervous System Mating Behavior Nephron Tubule Development DNA-binding Transcription Factor Activity Renal Tubule Development One-carbon Compound Transport Neuron Fate Specification Tissue Development Cell Differentiation Involved In Kidney Development Reproductive Behavior Positive Regulation Of Multicellular Organism Growth Neuroepithelial Cell Differentiation Neuron Fate Commitment Cell Migration Positive Regulation Of Cell Population Proliferation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding System Development Cell Motility Glial Cell Development Chromatin
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