GNA13 and TSHR

Number of citations of the paper that reports this interaction (PMID 8552586)
25

Data Source:
HPRD (in vivo)

		GNA13	TSHR
Gene Name		guanine nucleotide binding protein (G protein), alpha 13	thyroid stimulating hormone receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 1 Angiotensin Receptor Binding D5 Dopamine Receptor Binding Metal Ion Binding	Thyroid-stimulating Hormone Receptor Activity Protein Binding
	Biological Process	Patterning Of Blood Vessels In Utero Embryonic Development Movement Of Cell Or Subcellular Component Signal Transduction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Blood Coagulation Regulation Of Cell Shape Cell Differentiation Platelet Activation Regulation Of Cell Migration Activation Of Phospholipase D Activity	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell-cell Signaling Positive Regulation Of Cell Proliferation Thyroid-stimulating Hormone Signaling Pathway
Pathways		Thrombin signalling through proteinase activated receptors (PARs) Signaling by GPCR GPCR downstream signaling Thromboxane signalling through TP receptor G alpha (12/13) signalling events Signal amplification Platelet activation, signaling and aggregation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Thyrotropin Alfa
Diseases
GWAS			Graves' disease ( 21841780) Hair morphology ( 19896111) Optic disc size (rim) ( 20395239) Visceral fat ( 22589738)
Protein-Protein Interactions		31 interactors: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR	24 interactors: ADRB2 CALR CANX FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HSPA5 JAK1 JAK2 LHCGR PIK3R1 RABAC1 SCRIB STAT3 TSHB UBC
Entrez ID		10672	7253
HPRD ID		05100	04537
Ensembl ID		ENSG00000120063	ENSG00000165409
Uniprot IDs		B7Z7R0 F5H1G8 Q14344	F5GYU5 P16473
PDB IDs			1XUM 2XWT 3G04
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Catalytic Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Signaling Regulation Of Signaling Cell Communication Regulation Of Catalytic Activity Regulation Of Signal Transduction Cellular Response To Stimulus Cytosolic Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Activation Cellular Chemical Homeostasis Ion Homeostasis Apoptotic Process Programmed Cell Death Response To Stimulus Positive Regulation Of Hydrolase Activity Cellular Response To Organic Substance Cell Death Death Chemical Homeostasis Cellular Homeostasis Regulation Of Cellular Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Intracellular Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Platelet Activation Homeostatic Process Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Cellular Metabolic Process Termination Of Signal Transduction	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Platelet Activation Blood Coagulation Hemostasis Wound Healing Response To Wounding Regulation Of Body Fluid Levels Signaling Cell Communication Response To Stress Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell Activation Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Response To Stimulus Regulation Of Adenylate Cyclase Activity Developmental Process Regulation Of Cyclase Activity Cellular Response To Stimulus Regulation Of CAMP Biosynthetic Process Dopamine Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of CAMP Metabolic Process Response To Organic Substance Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Localization Anatomical Structure Development Establishment Of Localization In Cell Regulation Of Signaling Regulation Of Cell Migration Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Motility Growth Hormone Receptor Signaling Pathway Response To Hormone Cellular Response To Growth Hormone Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Cell Differentiation Multicellular Organismal Development Activation Of Adenylate Cyclase Activity Response To Cytokine Regulation Of Cellular Process Cellular Response To Organic Substance
Tagcloud ?		18q 19p13 1q aberrations arising burkitt collaborating cooperate copy deep enhancer gains id3 immunoglobulin lymphoma microrna myc next profiling recurrent scope sequencing signatures smarca4 subgroups summary transcriptome widened yielded	adenomas autonomous autonomy characterised constitutive disseminated evaluates f fdg focal focally gain goiters head hypermetabolism invoked iodine metabolism neck nodules pet radioiodine served simultaneous ten thyroid thyrotropin toxic twenty
Tagcloud (Difference) ?		18q 19p13 1q aberrations arising burkitt collaborating cooperate copy deep enhancer gains id3 immunoglobulin lymphoma microrna myc next profiling recurrent scope sequencing signatures smarca4 subgroups summary transcriptome widened yielded	adenomas autonomous autonomy characterised constitutive disseminated evaluates f fdg focal focally gain goiters head hypermetabolism invoked iodine metabolism neck nodules pet radioiodine served simultaneous ten thyroid thyrotropin toxic twenty
Tagcloud (Intersection) ?