GNA13 and ARHGEF1

Number of citations of the paper that reports this interaction (PMID 9641916)
158

Data Source:
HPRD (in vivo)

		GNA13	ARHGEF1
Gene Name		guanine nucleotide binding protein (G protein), alpha 13	Rho guanine nucleotide exchange factor (GEF) 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Vesicular Exosome	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 1 Angiotensin Receptor Binding D5 Dopamine Receptor Binding Metal Ion Binding	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Patterning Of Blood Vessels In Utero Embryonic Development Movement Of Cell Or Subcellular Component Signal Transduction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Blood Coagulation Regulation Of Cell Shape Cell Differentiation Platelet Activation Regulation Of Cell Migration Activation Of Phospholipase D Activity	Rho Protein Signal Transduction Cell Proliferation Positive Regulation Of Rho GTPase Activity Termination Of G-protein Coupled Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis
Pathways		Thrombin signalling through proteinase activated receptors (PARs) Signaling by GPCR GPCR downstream signaling Thromboxane signalling through TP receptor G alpha (12/13) signalling events Signal amplification Platelet activation, signaling and aggregation	Signaling by GPCR GPCR downstream signaling Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Protein-Protein Interactions		31 interactors: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR	11 interactors: ATR CD44 CNKSR1 CSNK1E GNA13 HRAS PRKCA RAP1A RHOA SREBF2 TCF4
Entrez ID		10672	9138
HPRD ID		05100	03511
Ensembl ID		ENSG00000120063	ENSG00000076928
Uniprot IDs		B7Z7R0 F5H1G8 Q14344	Q6NX52 Q92888
PDB IDs			1IAP 1SHZ 3AB3 3ODO 3ODW 3ODX 3P6A
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Catalytic Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Signaling Regulation Of Signaling Cell Communication Regulation Of Catalytic Activity Regulation Of Signal Transduction Cellular Response To Stimulus Cytosolic Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Activation Cellular Chemical Homeostasis Ion Homeostasis Apoptotic Process Programmed Cell Death Response To Stimulus Positive Regulation Of Hydrolase Activity Cellular Response To Organic Substance Cell Death Death Chemical Homeostasis Cellular Homeostasis Regulation Of Cellular Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Intracellular Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Platelet Activation Homeostatic Process Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Cellular Metabolic Process Termination Of Signal Transduction	Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Positive Regulation Of Intracellular Signal Transduction Ras Protein Signal Transduction Response To Stress Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of ERK1 And ERK2 Cascade Response To Wounding Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of ERK1 And ERK2 Cascade Platelet Activation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Rho Protein Signal Transduction Signal Transduction Cell Cycle Process Tissue Development Regulation Of Intracellular Signal Transduction Epithelium Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Small GTPase Mediated Signal Transduction Signaling Cell Communication Positive Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Regulation Of Signaling Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Cycle Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Peptidyl-serine Phosphorylation Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Energy Reserve Metabolic Process Tube Morphogenesis Response To Organic Substance Positive Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Morphogenesis Morphogenesis Of An Epithelium Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus
Tagcloud ?		18q 19p13 1q aberrations arising burkitt collaborating cooperate copy deep enhancer gains id3 immunoglobulin lymphoma microrna myc next profiling recurrent scope sequencing signatures smarca4 subgroups summary transcriptome widened yielded	activates angiotensin arterial arteries causative elusive environmental exchange feature frequent guanine hypertension ii inactivation industrialized monomeric muscle pathologies phosphorylates recognized remains responsible rhoa smooth specifically tyr738 unclear undescribed world
Tagcloud (Difference) ?		18q 19p13 1q aberrations arising burkitt collaborating cooperate copy deep enhancer gains id3 immunoglobulin lymphoma microrna myc next profiling recurrent scope sequencing signatures smarca4 subgroups summary transcriptome widened yielded	activates angiotensin arterial arteries causative elusive environmental exchange feature frequent guanine hypertension ii inactivation industrialized monomeric muscle pathologies phosphorylates recognized remains responsible rhoa smooth specifically tyr738 unclear undescribed world
Tagcloud (Intersection) ?