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MTNR1A and RAP1A
Number of citations of the paper that reports this interaction (PMID
17215244
)
14
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
MTNR1A
RAP1A
Gene Name
melatonin receptor 1A
RAP1A, member of RAS oncogene family
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Cytoplasm
Early Endosome
Late Endosome
Cytosol
Plasma Membrane
Cell Junction
Guanyl-nucleotide Exchange Factor Complex
Neuron Projection
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Melatonin Receptor Activity
Hormone Binding
Organic Cyclic Compound Binding
GTPase Activity
Protein Binding
GTP Binding
Protein Transporter Activity
Ras GTPase Binding
Rap Guanyl-nucleotide Exchange Factor Activity
Protein Complex Binding
Biological Process
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Mating Behavior
Circadian Rhythm
Positive Regulation Of CGMP Biosynthetic Process
Activation Of MAPKK Activity
Energy Reserve Metabolic Process
Signal Transduction
Blood Coagulation
Positive Regulation Of Neuron Projection Development
Protein Transport
Microvillus Assembly
Platelet Activation
Rap Protein Signal Transduction
Positive Regulation Of Rap GTPase Activity
Nerve Growth Factor Signaling Pathway
Small Molecule Metabolic Process
Positive Regulation Of Protein Kinase Activity
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Insulin Secretion
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Regulation Of Cell Junction Assembly
Cellular Response To Nerve Growth Factor Stimulus
Negative Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Vasculogenesis
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
GPCR downstream signaling
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
Signalling to ERKs
Signalling by NGF
Prolonged ERK activation events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Integration of energy metabolism
Regulation of insulin secretion
p130Cas linkage to MAPK signaling for integrins
Integrin alphaIIb beta3 signaling
NGF signalling via TRKA from the plasma membrane
GRB2:SOS provides linkage to MAPK signaling for Integrins
Platelet Aggregation (Plug Formation)
ARMS-mediated activation
Rap1 signalling
Platelet activation, signaling and aggregation
Frs2-mediated activation
Adaptive Immune System
Drugs
Ramelteon
Melatonin
Agomelatine
Diseases
GWAS
Obesity (
21552555
)
Osteoporosis (
20548944
)
Protein-Protein Interactions
26 interactors:
CALR
CANX
CNP
DPM1
EEF1G
FLNA
GNA11
GNA13
GNAI1
GNAI2
GNAI3
GNB1
GNB4
GPR50
HNRNPA0
HSPA5
IRS4
LRRC59
MTNR1B
PDIA6
PGRMC1
RAB10
RAC1
RAP1A
TMEM33
VAPB
41 interactors:
APBB1IP
ARHGEF1
BIN1
BMX
BRAF
FADD
FAF1
FAS
GABARAPL2
GANAB
HDAC1
HSPA1A
KRIT1
MLLT4
MTNR1A
NTRK1
PDE6D
PPP2R1A
PRKACA
RABAC1
RAF1
RALA
RALGDS
RAP1GAP
RAP1GDS1
RAPGEF2
RAPGEF3
RAPGEF4
RAPGEF5
RAPGEF6
RASA1
RASA3
RASGRP2
RASGRP4
RASIP1
RGL4
RGS14
RUNDC3A
SMARCA4
TCEB3
TNFRSF10C
Entrez ID
4543
5906
HPRD ID
02812
01545
Ensembl ID
ENSG00000168412
ENSG00000116473
Uniprot IDs
P48039
A8KAH9
P62834
PDB IDs
1C1Y
1GUA
3KUC
Enriched GO Terms of Interacting Partners
?
Platelet Activation
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Blood Coagulation
Hemostasis
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Regulation Of Body Fluid Levels
Wound Healing
Cell Activation
Response To Wounding
Signaling
Cell Communication
Response To Stimulus
G-protein Coupled Receptor Signaling Pathway
Signal Transduction
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Response To Organic Substance
Positive Regulation Of Nuclease Activity
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Kinase Activity
Vesicle-mediated Transport
Positive Regulation Of Transferase Activity
Response To Stress
Synaptic Transmission
Cell-cell Signaling
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Unfolded Protein
ER-nucleus Signaling Pathway
Cellular Response To Stimulus
Cellular Response To Topologically Incorrect Protein
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Kinase Activity
Dopamine Receptor Signaling Pathway
Substantia Nigra Development
Cellular Response To Organic Substance
Response To Unfolded Protein
Regulation Of Kinase Activity
Membrane Organization
Positive Regulation Of Phosphorylation
Response To Endoplasmic Reticulum Stress
Cell Surface Receptor Signaling Pathway
Neural Nucleus Development
Positive Regulation Of Protein Modification Process
Ras Protein Signal Transduction
Regulation Of Protein Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Kinase Activity
Response To Peptide Hormone
Midbrain Development
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Hydrolase Activity
Regulation Of GTPase Activity
Positive Regulation Of GTPase Activity
Positive Regulation Of Metabolic Process
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Rap GTPase Activity
Regulation Of Small GTPase Mediated Signal Transduction
Small GTPase Mediated Signal Transduction
Regulation Of Signaling
Regulation Of Ras Protein Signal Transduction
Regulation Of Ras GTPase Activity
Regulation Of Rap GTPase Activity
Positive Regulation Of Ras GTPase Activity
Intracellular Signal Transduction
Regulation Of Rap Protein Signal Transduction
Signal Transduction
Cell Communication
Regulation Of Metabolic Process
Cellular Response To Stimulus
Signaling
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Stimulus
Ras Protein Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Neurotrophin Signaling Pathway
Regulation Of Cellular Process
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Positive Regulation Of Cyclic Nucleotide Metabolic Process
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Apoptotic Process
Regulation Of Cell Death
Cell Activation
Regulation Of Protein Kinase Activity
Negative Regulation Of Signaling
Regulation Of Kinase Activity
Cell Surface Receptor Signaling Pathway
Platelet Activation
Regulation Of Cell Differentiation
Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Signal Transduction
Positive Regulation Of Lyase Activity
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Cell Differentiation
Tagcloud
?
bfa
bisphosphonates
brefeldin
camp
cathepsin
cdc42
cytoskeletal
diminish
diminished
epac
epac1
epac2
esi
fak
intermediates
isoprenylation
ko
multinucleated
nfatc1
nfkb
osteoclast
osteopontin
pctp
permit
rac1
rankl
raw264
rhoa
Tagcloud (Difference)
?
bfa
bisphosphonates
brefeldin
camp
cathepsin
cdc42
cytoskeletal
diminish
diminished
epac
epac1
epac2
esi
fak
intermediates
isoprenylation
ko
multinucleated
nfatc1
nfkb
osteoclast
osteopontin
pctp
permit
rac1
rankl
raw264
rhoa
Tagcloud (Intersection)
?